Adaptive autoregressive identification with spectral power decomposition for studying movement-related activity in scalp EEG signals and basal ganglia local field potentials

It is well established that parkinsonian syndrome is associated with alterations in the temporal pattern of neuronal activity and local field potentials in the basal ganglia (BG). An increase in synchronized oscillations has been observed in different BG nuclei in parkinsonian patients and animal models of this disease. However, the mechanisms underlying this phenomenon remain unclear. This study investigates the functional connectivity in the cortex-BG network of a rodent model of Parkinson's disease. Single neurons and local field potentials were simultaneously recorded in the motor cortex, the striatum, and the substantia nigra pars reticulata (SNr) of freely moving rats, and high-voltage spindles (HVSs) were used to compare signal transmission before and after dopaminergic depletion. It is shown that dopaminergic lesion results in a significant enhancement of oscillatory synchronization in the BG: the coherence between pairs of structures increased significantly and the percentage of oscillatory auto- and cross-correlograms. HVS episodes were also more numerous and longer. These changes were associated with a shortening of the latency of SNr response to cortical activation, from 40.5 ± 4.8 to 10.2 ± 1.07 ms. This result suggests that, in normal conditions, SNr neurons are likely to be driven by late inputs from the indirect pathway; however, after the lesion, their shorter latency also indicates an overactivation of the hyperdirect pathway. This study confirms that neuronal signal transmission is altered in the BG after dopamine depletion but also provides qualitative evidence for these changes at the cellular level.

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Functional Use of Directional Local Field Potentials in Parkinson's Disease

Neurosurgery ◽

10.1093/neuros/nyz310_210 ◽

2019 ◽

Vol 66 (Supplement_1) ◽

Author(s):

Ilknur Telkes ◽

Jennifer Durphy ◽

Octavian Adam ◽

Nataly Raviv ◽

Julie G Pilitsis

Keyword(s):

Local Field ◽

Power Distribution ◽

Spectral Power ◽

Local Field Potentials ◽

Field Potentials ◽

Beta Band ◽

Frequency Spectra ◽

Spectral Dynamics ◽

Stimulation Parameters ◽

Beta Power

Abstract INTRODUCTION One of the biggest limitations of deep brain stimulation (DBS) therapy is the stimulation induced side effects due to restricted size of functional areas in subthalamic nucleus (STN) and the proximity of structures. The segmented DBS lead technology aims to address this problem by delivering more selected, focal modulation via smaller, directional contacts. However, the DBS programming becomes more complex and time-consuming for clinical feasibility. Here in this pilot study, we investigated the spectral power distribution of directional local field potentials (LFPs) in STN and their relationship to motor symptoms of Parkinson disease (PD). METHODS We recorded 8-channel intraoperative LFPs in 9 PD patients at resting and during stimulation OFF. Power-frequency spectra were computed for all individual contacts and then grouped according to which anatomical directions they are facing. Beta (13-20 Hz/20-35 Hz) and alpha (7-12 Hz) band powers were calculated and their correlation to preoperative UPDRS-3 scores (51.7 ± 21.9 d before the DBS surgery) and the clinical programming were evaluated. RESULTS The average depth-frequency maps demonstrated different spectral dynamics across anterior, medial, and lateral directions. Patients with severe tremor compared to nontremor subjects showed higher beta power in anterior and lateral directions. Beta band power were positively correlated with the tremor severity and significantly correlated with clinical stimulation amplitude (mA) in anterior direction (P < .05). Correlation analysis between beta power and the other UPDRS-3 items such as bradykinesia/rigidity or postural instability and gait disturbance did not show clear trends towards a direction. CONCLUSION Given that testing all possible combinations of contact pairs and stimulation parameters is not feasible in a single clinic visit, spatio-spectral dynamics obtained from intraoperative recordings of LFPs might be used as an initial marker to select optimal contact (s). LFPs carry pathological signatures of PD and they might provide a functional use to predict optimal stimulation parameters in future. These features as well as higher frequency and cross-coupling dynamics of LFPs need to be studied in detail with larger subject populations.

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Spike Synchronization in the Cortex-Basal Ganglia Networks of Parkinsonian Primates Reflects Global Dynamics of the Local Field Potentials

Journal of Neuroscience ◽

10.1523/jneurosci.4848-03.2004 ◽

2004 ◽

Vol 24 (26) ◽

pp. 6003-6010 ◽

Cited By ~ 140

Author(s):

J. A. Goldberg

Keyword(s):

Basal Ganglia ◽

Local Field ◽

Local Field Potentials ◽

Global Dynamics ◽

Field Potentials

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Analyzing Local Field Potentials in the healthy basal ganglia under Deep Brain Stimulation

49th IEEE Conference on Decision and Control (CDC) ◽

10.1109/cdc.2010.5717450 ◽

2010 ◽

Cited By ~ 1

Author(s):

Gilda Pedoto ◽

Sabato Santaniello ◽

Erwin B. Montgomery ◽

John T. Gale ◽

Giovanni Fiengo ◽

...

Keyword(s):

Deep Brain Stimulation ◽

Basal Ganglia ◽

Local Field ◽

Brain Stimulation ◽

Local Field Potentials ◽

Field Potentials ◽

Deep Brain

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Interaction Between Rhythms in the Human Basal Ganglia: Application of Bispectral Analysis to Local Field Potentials

IEEE Transactions on Neural Systems and Rehabilitation Engineering ◽

10.1109/tnsre.2007.907893 ◽

2007 ◽

Vol 15 (4) ◽

pp. 483-492 ◽

Cited By ~ 26

Author(s):

S. Marceglia ◽

A.M. Bianchi ◽

G. Baselli ◽

G. Foffani ◽

F. Cogiamanian ◽

...

Keyword(s):

Basal Ganglia ◽

Local Field ◽

Local Field Potentials ◽

Field Potentials ◽

Bispectral Analysis

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Gating of attentional effort through the central thalamus

Journal of Neurophysiology ◽

10.1152/jn.00317.2011 ◽

2013 ◽

Vol 109 (4) ◽

pp. 1152-1163 ◽

Cited By ~ 30

Author(s):

N. D. Schiff ◽

S. A. Shah ◽

A. E. Hudson ◽

T. Nauvel ◽

S. F. Kalik ◽

...

Keyword(s):

Task Performance ◽

Local Field ◽

Spectral Power ◽

Local Field Potentials ◽

Delay Period ◽

Field Potentials ◽

Short Term ◽

Thalamic Neurons ◽

Firing Rates ◽

Central Thalamus

The central thalamus plays an important role in the regulation of arousal and allocation of attentional resources in the performance of even simple tasks. To assess the contribution of central thalamic neurons to short-term adjustments of attentional effort, we analyzed 166 microelectrode recordings obtained from two rhesus monkeys performing a visuomotor simple reaction time task with a variable foreperiod. Multiunit responses showed maintained firing rate elevations during the variable delay period of the task in ∼24% of recording sites. Simultaneously recorded local field potentials demonstrated significant decreases in power at ∼10–20 Hz and increases in power at 30–100 Hz during the delay period when compared against precue baselines. Comparison of the spectral power of local field potentials during the delay period of correct and incorrect trials showed that, during incorrect trials, similar, but reduced, shifts of spectral power occurred within the same frequency bands. Sustained performance of even simple tasks requires regulation of arousal and attention that combine in the concept of “attentional effort”. Our findings suggest that central thalamic neurons regulate task performance through brief changes in firing rates and spectral power changes during task-relevant short-term shifts of attentional effort. Increases in attentional effort may be reflected in changes within the central thalamic local populations, where correct task performance associates with more robust maintenance of firing rates during the delay period. Such ongoing fluctuations of central thalamic activity likely reflect a mix of influences, including variations in moment-to-moment levels of motivation, arousal, and availability of cognitive resources.

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