scholarly journals Difference in serum magnesium level among patients with stable chronic obstructive pulmonary disease (COPD) and exacerbated COPD

2018 ◽  
Vol 125 ◽  
pp. 012151
Author(s):  
R Sanowara ◽  
E N Keliat ◽  
A Abidin
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Serum Magnesium ◽  
Magnesium Level ◽  
Chronic Obstructive ◽  
Serum Magnesium Level ◽  
Obstructive Pulmonary Disease

scholarly journals Association of Serum Magnesium Levels with Frequency of Acute Exacerbations in Chronic Obstructive Pulmonary Disease: A Prospective Study

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Aziz Gumus ◽  
Muge Haziroglu ◽  
Yilmaz Gunes
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Pulmonary Function Tests ◽  
Serum Magnesium ◽  
Magnesium Level ◽  
Chronic Obstructive ◽  
Serum Magnesium Level ◽  
Obstructive Pulmonary Disease ◽  
Arterial Blood ◽  
Acute Exacerbations

Background. The course of chronic obstructive pulmonary disease (COPD) is accompanied by acute exacerbations. The purpose of this study is to determine the association of serum magnesium level with acute exacerbations in COPD (COPD-AE).Materials and Methods. Eighty-nine patients hospitalized with COPD-AE were included. Hemogram, biochemical tests, and arterial blood gases were analyzed. Pulmonary function tests were performed in the stable period after discharge. Patients were followed up at 3 monthly periods for one year.Results. Mean age of the patients was70.4±7.8(range 47–90) years. Mean number of COPD-AE during follow-up was4.0±3.6(range 0–15). On Spearman correlation analysis there were significant negative correlations between number of COPD-AE and predicted FEV1% (P=0.001), total protein (P=0.024), globulin (P=0.001), creatinine (P=0.001), and uric acid levels (P=0.036). There were also significant positive correlations between number of COPD-AE and serum magnesium level (P<0.001) and platelet count (P=0.043). According to linear regression analysis predicted FEV1% (P=0.011), serum magnesium (P<0.001), and globulin (P=0.006) levels were independent predictors of number of COPD-AE.Conclusions. In this small prospective observational study we found that serum magnesium level during exacerbation period was the most significant predictor of frequency of COPD-AE.

scholarly journals CLINICAL ASSOCIATION OF SERUM MAGNESIUM AND SERUM FIBRINOGEN LEVELS WITH ACUTE EXACERBATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE – A PROSPECTIVE OBSERVATIONAL STUDY

2018 ◽  
Vol 11 ◽  
Author(s):  
Niventhi A ◽  
Praveen D ◽  
Vijey Aanandhi M
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Serum Magnesium ◽  
High Serum ◽  
Annual Number ◽  
Chronic Obstructive ◽  
Lung Function Decline ◽  
Obstructive Pulmonary Disease ◽  
Stable Type ◽  
Low Serum

Objective: Acute exacerbations (AE) are a contributing cause of worsening chronic obstructive pulmonary disease (COPD) in conditions of lung function decline, quality of liveliness, and natural selection. The most important concept of this article is the positive correlation between the serum magnesium levels at worsening of symptoms and annual number of episodes. Methods: Blood samples from the patients who are diagnosed with AE of COPD will be collected and evaluated for serum magnesium levels and serum fibrinogen levels. Low serum magnesium is a modifiable risk factor. It is generally believed that, due to its bronchodilating effect, a decreased level of magnesium increases COPD exacerbations. The best blood biomarker for the systemic tenderness in COPD used here is plasma fibrinogen. Those with the increased fibrinogen levels had induced the higher admission rates with COPD. This clause deals with the association of both serum magnesium and serum fibrinogen levels with AE-COPD. Results: The serum magnesium levels on discharge in stable type were found to be 2.3±0.27, and in exacerbation, it was found to be 1.56±0.37. Moreover, on discharge, serum fibrinogen levels in stable type were found to be 1.64±0.32, and in exacerbation, it was found to be 2.18±0.40. Conclusion: Low serum magnesium levels may be a complication for AE of COPD. High serum fibrinogen levels may be a complication for AE of COPD. We hereby recommend regular screening of serum magnesium and serum fibrinogen levels for all the COPD patients to predict and prevent AE.

Oral and Oropharyngeal Sensory Function in Adults With Chronic Obstructive Pulmonary Disease

2020 ◽  
Vol 29 (2) ◽  
pp. 864-872
Author(s):  
Fernanda Borowsky da Rosa ◽  
Adriane Schmidt Pasqualoto ◽  
Catriona M. Steele ◽  
Renata Mancopes
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Oral Cavity ◽  
Pulmonary Disease ◽  
Thermal Sensation ◽  
Sensory Function ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Age Related ◽  
Copd Patients

Introduction The oral cavity and pharynx have a rich sensory system composed of specialized receptors. The integrity of oropharyngeal sensation is thought to be fundamental for safe and efficient swallowing. Chronic obstructive pulmonary disease (COPD) patients are at risk for oropharyngeal sensory impairment due to frequent use of inhaled medications and comorbidities including gastroesophageal reflux disease. Objective This study aimed to describe and compare oral and oropharyngeal sensory function measured using noninstrumental clinical methods in adults with COPD and healthy controls. Method Participants included 27 adults (18 men, nine women) with a diagnosis of COPD and a mean age of 66.56 years ( SD = 8.68). The control group comprised 11 healthy adults (five men, six women) with a mean age of 60.09 years ( SD = 11.57). Spirometry measures confirmed reduced functional expiratory volumes (% predicted) in the COPD patients compared to the control participants. All participants completed a case history interview and underwent clinical evaluation of oral and oropharyngeal sensation by a speech-language pathologist. The sensory evaluation explored the detection of tactile and temperature stimuli delivered by cotton swab to six locations in the oral cavity and two in the oropharynx as well as identification of the taste of stimuli administered in 5-ml boluses to the mouth. Analyses explored the frequencies of accurate responses regarding stimulus location, temperature and taste between groups, and between age groups (“≤ 65 years” and “> 65 years”) within the COPD cohort. Results We found significantly higher frequencies of reported use of inhaled medications ( p < .001) and xerostomia ( p = .003) in the COPD cohort. Oral cavity thermal sensation ( p = .009) was reduced in the COPD participants, and a significant age-related decline in gustatory sensation was found in the COPD group ( p = .018). Conclusion This study found that most of the measures of oral and oropharyngeal sensation remained intact in the COPD group. Oral thermal sensation was impaired in individuals with COPD, and reduced gustatory sensation was observed in the older COPD participants. Possible links between these results and the use of inhaled medication by individuals with COPD are discussed.

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