scholarly journals Soft iontronic delivery devices based on an intrinsically stretchable ion selective membrane

2021 ◽  
Author(s):  
Dennis Cherian ◽  
Samuel Lienemann ◽  
Tobias Abrahamsson ◽  
Nara Kim ◽  
Magnus Berggren ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ion Exchange ◽  
Controlled Drug Delivery ◽  
Controlled Delivery ◽  
Ion Exchange Membranes ◽  
Delivery Device ◽  
Energy Devices ◽  
Skin Patch ◽  
Selective Membrane ◽  
Drug Delivery Devices

Abstract Implantable electronically controlled drug delivery devices can provide precision theraputic treatments by highly spatiotemporally controlled delivery. Iontronic delivery devices rely on the movement of ions rather than liquid, and can therefore achieve electronically controlled precision delivery in a compact setting without disturbing the microenvironment within the tissue with fluid flow. For maximum precision, the delivery device needs to be closely integrated into the tissue, which is challenging due to the mechanical mismatch between the soft tissue and the harder devices. Here we address this challenge by developing a soft and stretchable iontronic delivery device. By formulating an ink based on an in-house synthesized hyperbranched polyelectrolyte, water dispersed polyurethane, and a thickening agent, a viscous ink is developed for stencil patterning of soft ion exchange membranes. We use this ink for developing soft and stretchable delivery devices, which are characterized both in the relaxed and stretched state. We find that their functionality is preserved up to 100 % strain, with small variations in resistance due to the strain. Finally, we develop a skin patch to demonstrate the outstanding conformability of the developed device. The presented technology is attractive for future soft implantable delivery devices, and the stretchable ion exchange membranes may also find applications within wearable energy devices.

A Thermoresponsive Hydrogel Based Controlled Drug Delivery Device

2012 ◽  
Author(s):  
Letia Blanco ◽  
Panos S. Shiakolas ◽  
Pranesh B. Aswath ◽  
Christopher B. Alberts ◽  
Chris Grace ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Protein Delivery ◽  
Controlled Drug Delivery ◽  
Solution Temperature ◽  
Delivery Device ◽  
Element Analysis ◽  
Loop Control ◽  
Glycol Diacrylate ◽  
Drug Delivery Device ◽  
And Performance

Thermoresponsive hydrogels exhibit the unique property of volume change as a function of change in temperature as they transition between hydrophilic and hydrophobic states. These hydrogels can be loaded with drug/protein and serve as reservoirs for drug/protein delivery applications. A hydrogel based device for controlled drug delivery is designed with a number of subsystems that are interfaced with LabVIEW for development of a functional device. The device was designed using analytical and finite element analysis procedures and fabricated. In this manuscript, the device design will be reviewed and discussed. A parametric study was performed to examine the device operation and performance as function of hydrogel heating/cooling temperature profiles. Subsequently, the device was employed in a series of experiments to examine the delivery of a protein as a function of thermal stimuli. The matrix used in this study was poly(ethylene glycol) diacrylate (PEGDA) and the drug delivery nanoparticles carriers were poly(N-isopropylacrylamide-co-acrylamide (PNIPAM) with a lower critical solution temperature (LCST) around 40°C. The protein of choice was bovine serum albumin (BSA). The results of this study illustrate that the development of a multi-drug or therapeutic delivery device is possible and that individual drugs can be delivered on demand using a closed loop control system.

Biologically Inspired Robotic Microswimmers

2009 ◽  
Author(s):  
William R. Hesse ◽  
Matthew Federici ◽  
David M. Casale ◽  
Peter Fink ◽  
Basil Milton ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Reynolds Number ◽  
Drug Delivery Systems ◽  
Controlled Drug Delivery ◽  
Specific Cell ◽  
Delivery Device ◽  
Biologically Inspired ◽  
Profound Impact ◽  
Drug Delivery Device

Drug delivery systems have had a profound impact on several branches of medicine. Engineers and researchers alike have labored to create a controlled drug delivery device capable of regulated dosage release and a specific cell targeting mechanism. The growing field of biomimicry has inspired several of these drug systems, though success has been limited. The flagellated low Reynolds number propulsion system of Salmonella typhimurium has inspired this specific delivery complex. In this system, the helical flagellar filaments of S. typhimurium are isolated from the bacteria’s cell body and are bound to functionalized paramagnetic microspheres. As a magnetic field is applied to this device, the microsphere rotates, inducing rotation of the helical flagella. This motion creates a locomotive force and drives the device in a predestined direction.

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