The Glutamate AMPA Receptor Antagonist, YM872, Attenuates Cortical Tissue Loss, Regional Cerebral Edema, and Neurological Motor Deficits after Experimental Brain Injury in Rats

2003 ◽  
Vol 20 (3) ◽  
pp. 269-278 ◽  
Author(s):  
Tetsuya Furukawa ◽  
Shigeru Hoshino ◽  
Shiro Kobayashi ◽  
Takayuki Asakura ◽  
Masayasu Takahashi ◽  
...  
Keyword(s):  
Brain Injury ◽  
Receptor Antagonist ◽  
Ampa Receptor ◽  
Cerebral Edema ◽  
Tissue Loss ◽  
Motor Deficits ◽  
Cortical Tissue ◽  
Ampa Receptor Antagonist

scholarly journals YM872, a Highly Water-Soluble AMPA Receptor Antagonist, Preserves the Hemodynamic Penumbra and Reduces Brain Injury After Permanent Focal Ischemia in Rats

Stroke ◽  
1998 ◽  
Vol 29 (10) ◽  
pp. 2141-2148 ◽  
Author(s):  
Masao Shimizu-Sasamata ◽  
Tsuneo Kano ◽  
Jadwiga Rogowska ◽  
Gerald L. Wolf ◽  
Michael A. Moskowitz ◽  
...  
Keyword(s):  
Brain Injury ◽  
Receptor Antagonist ◽  
Ampa Receptor ◽  
Focal Ischemia ◽  
Water Soluble ◽  
Ampa Receptor Antagonist ◽  
Permanent Focal Ischemia

AMPA Receptor Antagonist CFM-2 Decreases Survivin Expression in Cancer Cells

2018 ◽  
Vol 18 (4) ◽  
pp. 591-596 ◽  
Author(s):  
Domingo Sanchez Ruiz ◽  
Hella Luksch ◽  
Marco Sifringer ◽  
Achim Temme ◽  
Christian Staufner ◽  
...  
Keyword(s):  
Cell Survival ◽  
Receptor Antagonist ◽  
Cancer Cells ◽  
Glutamate Receptors ◽  
Cancer Cell ◽  
Ampa Receptor ◽  
Ampa Receptors ◽  
Survivin Expression ◽  
Ampa Receptor Antagonist ◽  
Cancer Cell Survival

Background: Glutamate receptors are widely expressed in different types of cancer cells. α-Amino-3- hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors are ionotropic glutamate receptors which are coupled to intracellular signaling pathways that influence cancer cell survival, proliferation, and migration. Blockade of AMPA receptors by pharmacologic compounds may potentially constitute an effective tool in anticancer treatment strategies. Method: Here we investigated the impact of the AMPA receptor antagonist CFM-2 on the expression of the protein survivin, which is known to promote cancer cell survival and proliferation. We show that CFM-2 inhibits survivin expression at mRNA and protein levels and decreases the viability of cancer cells. Using a stably transfected cell line which overexpresses survivin, we demonstrate that over-expression of survivin enhances cancer cell viability and attenuates CFM-2–mediated inhibition of cancer cell growth. Result: These findings point towards suppression of survivin expression as a new mechanism contributing to anticancer effects of AMPA antagonists.

Structural Determinants of the γ-8 TARP Dependent AMPA Receptor Antagonist

2017 ◽  
Vol 8 (12) ◽  
pp. 2631-2647 ◽  
Author(s):  
Matthew R. Lee ◽  
Kevin M. Gardinier ◽  
Douglas L. Gernert ◽  
Douglas A. Schober ◽  
Rebecca A. Wright ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Ampa Receptor ◽  
Structural Determinants ◽  
Ampa Receptor Antagonist

ChemInform Abstract: Two Intermediates in the Synthesis of Decahydroisoquinolines with NMDA and AMPA Receptor Antagonist Activity.

ChemInform ◽  
2010 ◽  
Vol 33 (1) ◽  
pp. no-no
Author(s):  
J. Zukerman-Schpector ◽  
Mauricio Vega ◽  
I. Caracelli ◽  
Luiz C. Dias ◽  
Anna M. A. P. Fernandes
Keyword(s):  
Receptor Antagonist ◽  
Ampa Receptor ◽  
Antagonist Activity ◽  
Ampa Receptor Antagonist
Sign in / Sign up

Export Citation Format

Share Document