Adenovirus Biodistribution and Noninvasive Imaging of Gene Expression In Vivo by Positron Emission Tomography Using Human Sodium/Iodide Symporter as Reporter Gene

2002 ◽  
Vol 13 (14) ◽  
pp. 1723-1735 ◽  
Author(s):  
Thomas Groot-Wassink ◽  
Eric O. Aboagye ◽  
Matthias Glaser ◽  
Nicholas R. Lemoine ◽  
Georges Vassaux
Keyword(s):  
Gene Expression ◽  
Positron Emission Tomography ◽  
Reporter Gene ◽  
Sodium Iodide ◽  
Noninvasive Imaging ◽  
Emission Tomography ◽  
Sodium Iodide Symporter ◽  
Positron Emission

In vivo assessment of adenoviral vector-mediated gene expression of dopamine D2 receptors in the rat striatum by positron emission tomography

Synapse ◽  
2002 ◽  
Vol 43 (3) ◽  
pp. 195-200 ◽  
Author(s):  
Hiroyuki Umegaki ◽  
Kiichi Ishiwata ◽  
Osamu Ogawa ◽  
Donald K. Ingram ◽  
George S. Roth ◽  
...  
Keyword(s):  
Gene Expression ◽  
Positron Emission Tomography ◽  
Adenoviral Vector ◽  
D2 Receptors ◽  
Dopamine D2 Receptors ◽  
Emission Tomography ◽  
Rat Striatum ◽  
Positron Emission ◽  
In Vivo Assessment

scholarly journals GENIS: gene expression of sodium iodide symporter for noninvasive imaging of gene therapy vectors and quantification of gene expression in vivo

2003 ◽  
Vol 8 (3) ◽  
pp. 508-518 ◽  
Author(s):  
Kenneth N Barton ◽  
Donald Tyson ◽  
Hans Stricker ◽  
Young S Lew ◽  
Gregory Heisey ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Therapy ◽  
Sodium Iodide ◽  
Noninvasive Imaging ◽  
Sodium Iodide Symporter ◽  
Gene Therapy Vectors

scholarly journals Positron-Emission Tomography Reporter Gene Expression Imaging in Rat Myocardium

Circulation ◽  
2003 ◽  
Vol 107 (2) ◽  
pp. 326-332 ◽  
Author(s):  
Masayuki Inubushi ◽  
Joseph C. Wu ◽  
Sanjiv S. Gambhir ◽  
Gobalakrishnan Sundaresan ◽  
Nagichettiar Satyamurthy ◽  
...  
Keyword(s):  
Gene Expression ◽  
Positron Emission Tomography ◽  
Reporter Gene ◽  
Reporter Gene Expression ◽  
Emission Tomography ◽  
Rat Myocardium ◽  
Positron Emission

scholarly journals Non-invasive imaging of radiocesium dynamics in a living animal using a positron-emitting 127Cs tracer

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Nobuo Suzui ◽  
Takuya Shibata ◽  
Yong-Gen Yin ◽  
Yoshihito Funaki ◽  
Keisuke Kurita ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Sodium Iodide ◽  
Emission Tomography ◽  
Sodium Ions ◽  
Living Animal ◽  
Non Invasive ◽  
Positron Emission ◽  
Tracer Solution ◽  
The Impact

Abstract Visualizing the dynamics of cesium (Cs) is desirable to understand the impact of radiocesium when accidentally ingested or inhaled by humans. However, visualization of radiocesium in vivo is currently limited to plants. Herein, we describe a method for the production and purification of 127Cs and its use in visualizing Cs dynamics in a living animal. The positron-emitting nuclide 127Cs was produced using the 127I (α, 4n) 127Cs reaction, which was induced by irradiation of sodium iodide with a 4He2+ beam from a cyclotron. We excluded sodium ions by using a material that specifically adsorbs Cs as a purification column and successfully eluted 127Cs by flowing a solution of ammonium sulfate into the column. We injected the purified 127Cs tracer solution into living rats and the dynamics of Cs were visualized using positron emission tomography; the distributional images showed the same tendency as the results of previous studies using disruptive methods. Thus, this method is useful for the non-invasive investigation of radiocesium in a living animal.

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