scholarly journals Laser Acupuncture Improves Tear Film Stability in Patients with Dry Eye Disease: A Two-Center Randomized-Controlled Trial

2021 ◽  
Author(s):  
Wen-Long Hu ◽  
Hun-Ju Yu ◽  
Li-Yen Pan ◽  
Pei-Chang Wu ◽  
Chih-Chin Pan ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Dry Eye ◽  
Controlled Trial ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Laser Acupuncture ◽  
Eye Disease ◽  
Film Stability ◽  
Randomized Controlled ◽  
Tear Film Stability

scholarly journals Easy and effective test to evaluate tear-film stability for self-diagnosis of dry eye syndrome: Blinking tolerance time (BTT)

2020 ◽  
Author(s):  
Hyung Bin Hwang ◽  
Yong Ho Ku ◽  
Eun Chul Kim ◽  
Hyun Seung Kim ◽  
Man Soo Kim ◽  
...  
Keyword(s):  
Dry Eye ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Controlled Study ◽  
Eye Disease ◽  
Cutoff Score ◽  
Time Interval ◽  
Film Stability ◽  
Tolerance Time ◽  
Tear Film Stability

Abstract Background: The tear film breakup time (tBUT) is a clinical evaluation of evaporative dry eye disease assessed by instilling topical fluorescein into the eyes. In the present study, we introduce a new diagnostic test, blinking tolerance time (BTT), for self-evaluation of tear-film stability. We compared the results with the tBUT and validated the BTT test for self-assessment of tear film instability.Methods: This was a prospective controlled study involving 212 eyes of 106 participants 20–79 years of age. A total of 114 eyes of 57 dry eye patients and 98 eyes of 49 healthy subjects were included in the study. All patients and subjects were administered the following tests to diagnose dry eye disease: Ocular Surface Disease Index, BTT, tBUT, slit-lamp examination, corneal stain score, and Schirmer I test (without anesthesia). Patients and subjects were instructed not to blink for as long possible after reset blinking. The time interval between the reset blink and the next blink was measured. The mean of 3 tBUT values in both the right and left eyes was defined as tBUTBE. Correlations between the BTT and tBUTBE were also evaluated. To evaluate the diagnostic efficacy of the BTT and tBUT tests, receiver operating characteristic (ROC) curves were generated to obtain a cutoff score, and the sensitivities of the tests against the specificity at all possible thresholds were plotted.Results: Spearman’s correlation analysis revealed a significant weakly positive correlation between BTT and tBUTBE (r = 0.447; p=0.000). The intraclass correlation coefficient (ICC) of the tBUT was 0.679 (95% confidence interval [CI]: 0.575–0.765) and the ICC of the BTT was 0.904 (95% CI: 0.867–0.932). The area under the ROC curve did not significantly differ between the tBUTBE (0.678) and BTT (0.628, p=0.641). When the cutoff value of the BTT test was set to 8.1 s, the sensitivity was 63.3% and the specificity was 56.1%.Conclusion: The BTT test is a simple, inexpensive, and effective method for self-diagnosing dry eye that can also be used in the clinical setting.

scholarly journals Randomized controlled trial of trehalose: An efficient autophagic bioprotectant in the management of dry eye disease

2020 ◽  
Vol 0 (0) ◽  
pp. 0
Author(s):  
ArvindKumar Morya ◽  
Kanchan Solanki ◽  
Sujeet Prakash ◽  
Monika Samota ◽  
Arushi Gupta
Keyword(s):  
Randomized Controlled Trial ◽  
Dry Eye ◽  
Controlled Trial ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Randomized Controlled

scholarly journals Easy and effective test to evaluate tear-film stability for self-diagnosis of dry eye syndrome: blinking tolerance time (BTT)

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Hyung Bin Hwang ◽  
Yong Ho Ku ◽  
Eun Chul Kim ◽  
Hyun Seung Kim ◽  
Man Soo Kim ◽  
...  
Keyword(s):  
Dry Eye ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Controlled Study ◽  
Eye Disease ◽  
Cutoff Score ◽  
Time Interval ◽  
Film Stability ◽  
Tolerance Time ◽  
Tear Film Stability

Abstract Background The tear film breakup time (tBUT) is a clinical evaluation of evaporative dry eye disease assessed by instilling topical fluorescein into the eyes. In the present study, we introduce a new diagnostic test, blinking tolerance time (BTT), for self-evaluation of tear-film stability. We compared the results with the tBUT and validated the BTT test for self-assessment of tear film instability. Methods This was a prospective controlled study involving 212 eyes of 106 participants 20–79 years of age. A total of 114 eyes of 57 dry eye patients and 98 eyes of 49 healthy subjects were included in the study. All patients and subjects were administered the following tests to diagnose dry eye disease: Ocular Surface Disease Index, BTT, tBUT, slit-lamp examination, corneal stain score, and Schirmer I test (without anesthesia). Patients and subjects were instructed not to blink for as long possible after reset blinking. The time interval between the reset blink and the next blink was measured. The mean of 3 tBUT values in both the right and left eyes was defined as tBUTBE. Correlations between the BTT and tBUTBE were also evaluated. To evaluate the diagnostic efficacy of the BTT and tBUT tests, receiver operating characteristic (ROC) curves were generated to obtain a cutoff score, and the sensitivities of the tests against the specificity at all possible thresholds were plotted. Results Spearman’s correlation analysis revealed a significant weakly positive correlation between BTT and tBUTBE (r = 0.447; p = 0.000). The intraclass correlation coefficient (ICC) of the tBUT was 0.679 (95% confidence interval [CI]: 0.575–0.765) and the ICC of the BTT was 0.904 (95% CI: 0.867–0.932). The area under the ROC curve did not significantly differ between the tBUTBE (0.678) and BTT (0.628, p = 0.641). When the cutoff value of the BTT test was set to 8.1 s, the sensitivity was 63.3% and the specificity was 56.1%. Conclusion The BTT test is a simple, inexpensive, and effective method for self-diagnosing dry eye that can also be used in the clinical setting.

Effect of Face Mask on Tear Film Stability in Eyes With Moderate-to-Severe Dry Eye Disease

Cornea ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Pedro Arriola-Villalobos ◽  
Barbara Burgos-Blasco ◽  
Beatriz Vidal-Villegas ◽  
Carlos Oribio-Quinto ◽  
Mayte Ariño-Gutiérrez ◽  
...  
Keyword(s):  
Dry Eye ◽  
Tear Film ◽  
Face Mask ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Film Stability ◽  
Tear Film Stability

scholarly journals An artificial tear containing flaxseed oil for treating dry eye disease: A randomized controlled trial

2020 ◽  
Vol 18 (1) ◽  
pp. 148-157 ◽  
Author(s):  
Laura E. Downie ◽  
Milton M. Hom ◽  
Gregg J. Berdy ◽  
Sherif El-Harazi ◽  
Anthony Verachtert ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Dry Eye ◽  
Controlled Trial ◽  
Flaxseed Oil ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Artificial Tear ◽  
Randomized Controlled

scholarly journals Acupuncture at a Single Acupoint, BL1 (Jingming), Compared to Artificial Tears in Moderate to Severe Dry Eye Disease: A Randomized Controlled Trial

2021 ◽  
Author(s):  
xue zhang ◽  
Bo Zhang ◽  
Siyang Peng ◽  
Guoliang Zhang ◽  
Jumei Ma ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Dry Eye ◽  
Primary Outcome ◽  
Controlled Trial ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Artificial Tears ◽  
Artificial Tear ◽  
Randomized Controlled

Abstract BackgroundThe global incidence of dry eye disease (DED) is very high. DED seriously affects the quality of life of patients; however, the current curative effect of medicine for moderate to severe DED is poor. This randomized clinical trial was planned to investigate the effect of acupuncture compared with artificial tears on moderate to severe DED.MethodsA randomized clinical trial was performed at 2 hospitals in China. 120 DED patients were randomly equally divided into an acupuncture and an artificial tear group. Either acupuncture or artificial tears was performed for an 8-week period, and a 32-week follow-up was performed. The primary outcome measure was the Schirmer-I test (SIT) value. The secondary outcome measures included the numerical rating scale (NRS) for improvement in ocular symptoms, the ocular surface disease index (OSDI), the tear-film break-up time (TBUT), corneal fluorescein staining (CFS), and acupuncture acceptability. Adverse events also were monitored and documented.ResultsFor the primary outcome, the mean changes in the SIT values were significantly different between the acupuncture (5.75 [2.53‒9.75]) and artificial tear (0.52 [-1.18‒2.46]) groups at week 8 (P = 0.01). The OSDI decreased by -16.14 (-35.40‒16.30) and − 7.65 (-19.25‒15.05) from baseline to week 8 in the acupuncture and artificial tear groups, respectively (P < 0.05). A significant decrease was found in the NRS score for eye dryness, eye pain, and blurred vision in the acupuncture group, as compared to the artificial tear group. However, the change in the average symptom NRS score, TBUT, and CFS did not differ significantly at week 8. Five cases experienced acupuncture-related adverse events.ConclusionsThis randomized clinical trial found that acupuncture at a single acupoint, BL1, significantly promoted tear secretion and improved multiple eye discomfort symptoms. Acupuncture showed greater benefits than artificial tears for moderate to severe DED. However, the study findings warrant verification.Trial registrationRegistration number: ChiCTR1800015831. Name of trial registry: Efficacy and safety of acupuncture in the treatment of moderate to severe dry eye disease: a randomized controlled trial.

scholarly journals The correction of conjunctivochalasis using high-frequency radiowave electrosurgery improves dry eye disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yong Woo Ji ◽  
Hyojin Seong ◽  
Sujung Lee ◽  
Mutlaq Hamad Alotaibi ◽  
Tae-im Kim ◽  
...  
Keyword(s):  
Dry Eye ◽  
High Frequency ◽  
Symptomatic Relief ◽  
Tear Film ◽  
Signs And Symptoms ◽  
Meibomian Gland ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Film Stability ◽  
Staining Score

AbstractWe aimed to determine the clinical impact of conjunctivochalasis (CCh) and its correction using high-frequency radiowave electrosurgery (HFR-ES), for signs and symptoms of dry eye disease (DED). Forty patients diagnosed with symptomatic CCh were prospectively enrolled. As a result, patients with CCh had moderate to severe DED and most of them exhibited meibomian gland dysfunction (MGD). Corneo-conjunctival fluorescein staining score (CFS) and all lid-parallel-conjunctival-folds scores (LIPCOFs) were positively correlated. Nasal LIPCOF significantly correlated with symptoms and tear volume. Central, temporal, and total LIPCOF significantly correlated with MG loss, MGD stage, and lipid layer thickness. Independent significant factors associated with total LIPCOF included CFS, tear break-up time, and MGD stage. One month following HFR-ES, CCh was completely resolved in all cases. Patient age and preoperative nasal LIPCOF were determinants of outcomes associated with postoperative improvements in symptoms. Ocular surface parameters significantly improved, but MGD-related signs did not. Collectively, CCh associated with MGD severity deteriorates not only tear film stability and reservoir capacity, leading to DED exacerbation. Therefore, CCh should be corrected in patients with DED and MGD. Younger patients with nasal CCh are likely to experience more symptomatic relief after HFR-ES. Particularly, management for MGD should be maintained after CCh correction.

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