scholarly journals The influence of cerebral small vessel disease on static and dynamic functional network connectivity in subjects along Alzheimer's disease continuum

2020 ◽  
Author(s):  
kaicheng LI ◽  
Zening Fu ◽  
Xiao Luo ◽  
Qingze Zeng ◽  
Peiyu Huang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Small Vessel Disease ◽  
Network Connectivity ◽  
Cerebral Small Vessel Disease ◽  
Functional Network ◽  
Small Vessel ◽  
Functional Network Connectivity ◽  
Vessel Disease ◽  
Dynamic Functional Network Connectivity

Different cognitive profiles between mild cognitive impairment due to cerebral small vessel disease and mild cognitive impairment of Alzheimer’s disease origin

2009 ◽  
Vol 15 (6) ◽  
pp. 898-905 ◽  
Author(s):  
AIHONG ZHOU ◽  
JIANPING JIA
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Processing Speed ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Cognitive Domains ◽  
Vessel Disease

AbstractControversy surrounds the differences of the cognitive profile between mild cognitive impairment resulting from cerebral small vessel disease (MCI-SVD) and mild cognitive impairment associated with prodromal Alzheimer’s disease (MCI-AD). The aim of this study was to explore and compare the cognitive features of MCI-SVD and MCI-AD. MCI-SVD patients (n = 56), MCI-AD patients (n = 30), and normal control subjects (n = 80) were comprehensively evaluated with neuropsychological tests covering five cognitive domains. The performance was compared between groups. Tests that discriminated between MCI-SVD and MCI-AD were identified. Multiple cognitive domains were impaired in MCI-SVD group, while memory and executive function were mainly impaired in MCI-AD group. Compared with MCI-SVD, MCI-AD patients performed relatively worse on memory tasks, but better on processing speed measures. The AVLT Long Delay Free Recall, Digit Symbol Test, and Stroop Test Part A (performance time) in combination categorized 91.1% of MCI-SVD patients and 86.7% of MCI-AD patients correctly. Current study suggested a nonspecific neuropsychological profile for MCI-SVD and a more specific cognitive pattern in MCI-AD. MCI-AD patients demonstrated greater memory impairment with relatively preserved mental processing speed compared with MCI-SVD patients. Tests tapping these two domains might be potentially useful for differentiating MCI-SVD and MCI-AD patients. (JINS, 2009, 15, 898–905.)

scholarly journals Cerebral small vessel disease in middle age and genetic predisposition to late-onset Alzheimer's disease

2017 ◽  
Vol 14 (2) ◽  
pp. 253-258 ◽  
Author(s):  
James D. Stefaniak ◽  
Li Su ◽  
Elijah Mak ◽  
Nasim Sheikh-Bahaei ◽  
Katie Wells ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genetic Predisposition ◽  
Middle Age ◽  
Small Vessel Disease ◽  
Late Onset ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Vessel Disease

Association of cerebral small vessel disease with delusions in patients with Alzheimer's disease

2012 ◽  
Vol 28 (1) ◽  
pp. 18-25 ◽  
Author(s):  
Yusuke Ogawa ◽  
Mamoru Hashimoto ◽  
Yusuke Yatabe ◽  
Keiichiro Kaneda ◽  
Kazuki Honda ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Vessel Disease

scholarly journals Association between cerebral small‐vessel disease and Alzheimer’s disease pathologies

2021 ◽  
Vol 17 (S5) ◽  
Author(s):  
Yuan Cai ◽  
Vincent C.T. Mok ◽  
Wanting Liu ◽  
Xiang Fan ◽  
Lin Shi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Vessel Disease

Cerebral small vessel disease and the risk of Alzheimer’s disease: A systematic review

2018 ◽  
Vol 47 ◽  
pp. 41-48 ◽  
Author(s):  
Yue Liu ◽  
Nady Braidy ◽  
Anne Poljak ◽  
Daniel K.Y. Chan ◽  
Perminder Sachdev
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Vessel Disease

scholarly journals Is Oxidative Stress the Link Between Cerebral Small Vessel Disease, Sleep Disruption, and Oligodendrocyte Dysfunction in the Onset of Alzheimer’s Disease?

2021 ◽  
Vol 12 ◽  
Author(s):  
Ana Lloret ◽  
Daniel Esteve ◽  
Maria Angeles Lloret ◽  
Paloma Monllor ◽  
Begoña López ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Sleep Disruption ◽  
Poor Sleep ◽  
Vessel Disease ◽  
Early Occurrence

Oxidative stress is an early occurrence in the development of Alzheimer’s disease (AD) and one of its proposed etiologic hypotheses. There is sufficient experimental evidence supporting the theory that impaired antioxidant enzymatic activity and increased formation of reactive oxygen species (ROS) take place in this disease. However, the antioxidant treatments fail to stop its advancement. Its multifactorial condition and the diverse toxicological cascades that can be initiated by ROS could possibly explain this failure. Recently, it has been suggested that cerebral small vessel disease (CSVD) contributes to the onset of AD. Oxidative stress is a central hallmark of CSVD and is depicted as an early causative factor. Moreover, data from various epidemiological and clinicopathological studies have indicated a relationship between CSVD and AD where endothelial cells are a source of oxidative stress. These cells are also closely related to oligodendrocytes, which are, in particular, sensitive to oxidation and lead to myelination being compromised. The sleep/wake cycle is another important control in the proliferation, migration, and differentiation of oligodendrocytes, and sleep loss reduces myelin thickness. Moreover, sleep plays a crucial role in resistance against CSVD, and poor sleep quality increases the silent markers of this vascular disease. Sleep disruption is another early occurrence in AD and is related to an increase in oxidative stress. In this study, the relationship between CSVD, oligodendrocyte dysfunction, and sleep disorders is discussed while focusing on oxidative stress as a common occurrence and its possible role in the onset of AD.

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