Hypersynchronized MEG brain networks in patients with mild cognitive impairment and Alzheimer's disease in Down syndrome

2021 ◽  
Author(s):  
Federico Ramírez Toraño ◽  
Javier García Alba ◽  
Ricardo Bruña ◽  
Susanna Esteba Castillo ◽  
Lucía Vaquero ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Down Syndrome ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Brain Networks

scholarly journals Group-level progressive alterations in brain connectivity patterns revealed by diffusion-tensor brain networks across severity stages in Alzheimer’s disease

2017 ◽  
Author(s):  
J. Rasero ◽  
C. Alonso-Montes ◽  
I. Diez ◽  
L. Olabarrieta-Landa ◽  
L. Remaki ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Disease Severity ◽  
Diffusion Tensor ◽  
Brain Networks ◽  
Stage Ii ◽  
Group Level ◽  
The Brain

AbstractAlzheimer’s disease (AD) is a chronically progressive neurodegenerative disease highly correlated to aging. Whether AD originates by targeting a localized brain area and propagates to the rest of the brain across disease-severity progression is a question with an unknown answer. Here, we aim to provide an answer to this question at the group-level by looking at differences in diffusion-tensor brain networks. In particular, making use of data from Alzheimer's Disease Neuroimaging Initiative (ADNI), four different groups were defined (all of them matched by age, sex and education level): G1 (N1=36, healthy control subjects, Control), G2 (N2=36, early mild cognitive impairment, EMCI), G3 (N3=36, late mild cognitive impairment, LMCI) and G4 (N4=36, AD). Diffusion-tensor brain networks were compared across three disease stages: stage I 3(Control vs EMCI), stage II (Control vs LMCI) and stage III (Control vs AD). The group comparison was performed using the multivariate distance matrix regression analysis, a technique that was born in genomics and was recently proposed to handle brain functional networks, but here applied to diffusion-tensor data. The results were three-fold: First, no significant differences were found in stage I. Second, significant differences were found in stage II in the connectivity pattern of a subnetwork strongly associated to memory function (including part of the hippocampus, amygdala, entorhinal cortex, fusiform gyrus, inferior and middle temporal gyrus, parahippocampal gyrus and temporal pole). Third, a widespread disconnection across the entire AD brain was found in stage III, affecting more strongly the same memory subnetwork appearing in stage II, plus the other new subnetworks,including the default mode network, medial visual network, frontoparietal regions and striatum. Our results are consistent with a scenario where progressive alterations of connectivity arise as the disease severity increases and provide the brain areas possibly involved in such a degenerative process. Further studies applying the same strategy to longitudinal data are needed to fully confirm this scenario.

scholarly journals Glucose Metabolism during Resting State Reveals Abnormal Brain Networks Organization in the Alzheimer’s Disease and Mild Cognitive Impairment

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e68860 ◽  
Author(s):  
Gretel Sanabria-Diaz ◽  
Eduardo Martínez-Montes ◽  
Lester Melie-Garcia ◽  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Glucose Metabolism ◽  
Resting State ◽  
Brain Networks ◽  
Abnormal Brain

scholarly journals Proteomic profiles of prevalent mild cognitive impairment and Alzheimer's disease among adults with Down syndrome

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Melissa Petersen ◽  
Fan Zhang ◽  
Sharon J. Krinsky‐McHale ◽  
Wayne Silverman ◽  
Joseph H. Lee ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Down Syndrome ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment

scholarly journals Relationship between Amyloid-β Deposition and the Coupling between Structural and Functional Brain Networks in Patients with Mild Cognitive Impairment and Alzheimer’s Disease

2021 ◽  
Vol 11 (11) ◽  
pp. 1535
Author(s):  
Hui Zhang ◽  
Edward S. Hui ◽  
Peng Cao ◽  
Henry K. F. Mak
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Brain Networks ◽  
Amyloid Β ◽  
Potential Candidate ◽  
Functional Brain ◽  
Specific Effects ◽  
Functional Brain Networks

Previous studies have demonstrated that the accumulation of amyloid-β (Aβ) pathologies has distinctive stage-specific effects on the structural and functional brain networks along the Alzheimer’s disease (AD) continuum. A more comprehensive account of both types of brain network may provide a better characterization of the stage-specific effects of Aβ pathologies. A potential candidate for this joint characterization is the coupling between the structural and functional brain networks (SC-FC coupling). We therefore investigated the effect of Aβ accumulation on global SC-FC coupling in patients with mild cognitive impairment (MCI), AD, and healthy controls. Patients with MCI were dichotomized according to their level of Aβ pathology seen in 18F-flutemetamol PET-CT scans—namely, Aβ-negative and Aβ-positive. Our results show that there was no difference in global SC-FC coupling between different cohorts. During the prodromal AD stage, there was a significant negative correlation between the level of Aβ pathology and the global SC-FC coupling of MCI patients with positive Aβ, but no significant correlation for MCI patients with negative Aβ. During the AD dementia stage, the correlation between Aβ pathology and global SC-FC coupling in patients with AD was positive. Our results suggest that Aβ pathology has distinctive stage-specific effects on global coupling between the structural and functional brain networks along the AD continuum.

scholarly journals Metabolic correlates of prevalent mild cognitive impairment and Alzheimer's disease in adults with Down syndrome

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Mark Mapstone ◽  
Thomas J Gross ◽  
Fabio Macciardi ◽  
Amrita K Cheema ◽  
Melissa Petersen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Down Syndrome ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment

Global Functional Coupling of Resting EEG Rhythms is Abnormal in Mild Cognitive Impairment and Alzheimer’s Disease

2009 ◽  
Vol 23 (4) ◽  
pp. 224-234 ◽  
Author(s):  
Claudio Babiloni ◽  
Giovanni Frisoni ◽  
Fabrizio Vecchio ◽  
Roberta Lizio ◽  
Michela Pievani ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Brain Networks ◽  
Elderly Subjects ◽  
Functional Coupling ◽  
Eeg Rhythms ◽  
Eyes Closed ◽  
Global Cognition

Alzheimer’s disease (AD) is typically associated with an impairment of brain networks and global cognitive function in aging. In this vein, the present study tested the hypothesis that the functional coupling of resting cortical electroencephalographic (EEG) rhythms is progressively abnormal in amnesic mild cognitive impairment (MCI) and AD subjects. Eyes-closed resting EEG data were recorded (10–20 system) in 33 mild AD, 52 amnesic MCI, and 47 normal elderly subjects (Nold). EEG rhythms of interest were delta (2–4 Hz), theta (4–8 Hz), alpha1 (8–10 Hz), alpha2 (10–13 Hz), beta1 (13–20 Hz), beta2 (20–30 Hz), and gamma (30–40 Hz). The global functional coupling of the EEG rhythms was indexed by means of spectral coherence for all combinations of electrode pairs (i.e., total coherence). The main results showed that the total coherence of delta rhythms was higher in the AD than the MCI group. It was also higher in the MCI than the Nold group. Furthermore, the delta total coherence was negatively correlated with global cognition (Mini Mental State Examination score) across the Nold, MCI, and AD subjects. Finally, the alpha1 total coherence was lower in the AD group than in the MCI and Nold groups. These results suggest that in the AD process an impairment of brain networks and global cognition is associated with a frequency-specific modulation of the global functional coupling of resting EEG rhythms.

P2-440: MEG CHARACTERIZATION OF ALZHEIMER'S DISEASE AND MILD COGNITIVE IMPAIRMENT IN PEOPLE WITH DOWN SYNDROME

2006 ◽  
Vol 14 (7S_Part_16) ◽  
pp. P884-P884
Author(s):  
Federico Ramirez Toraño ◽  
Javier García Alba ◽  
Ricardo Bruña Fernández
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Down Syndrome ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment

Neuropsychological and neurophysiological characterization of mild cognitive impairment and Alzheimer's disease in Down syndrome

2019 ◽  
Vol 84 ◽  
pp. 70-79 ◽  
Author(s):  
Javier García-Alba ◽  
Federico Ramírez-Toraño ◽  
Susanna Esteba-Castillo ◽  
Ricardo Bruña ◽  
Fernando Moldenhauer ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Down Syndrome ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment

P1-334: Functional brain networks integrity in patients with Alzheimer's disease and mild cognitive impairment

2011 ◽  
Vol 7 ◽  
pp. S218-S219 ◽  
Author(s):  
Michela Pievani ◽  
Federica Agosta ◽  
Massimo Filippi ◽  
Giovanni Frisoni
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Brain Networks ◽  
Functional Brain ◽  
Functional Brain Networks
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