Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism in Lung Cancer Patients

2012 ◽  
Vol 16 (7) ◽  
pp. 722-725 ◽  
Author(s):  
Sanja Dević Pavlić ◽  
Smiljana Ristić ◽  
Veljko Flego ◽  
Miljenko Kapović ◽  
Anđelka Radojčić Badovinac
Keyword(s):  
Lung Cancer ◽  
Gene Polymorphism ◽  
Angiotensin Converting Enzyme ◽  
Cancer Patients ◽  
Converting Enzyme ◽  
Lung Cancer Patients

scholarly journals Association between EGFR Gene Mutation and Antioxidant Gene Polymorphism of Non-Small-Cell Lung Cancer

Diagnostics ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 692
Author(s):  
Ching-Hsiung Lin ◽  
Po-Jen Yang ◽  
Sheng-Hao Lin ◽  
Kun-Tu Yeh ◽  
Thomas Chang-Yao Tsao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Gene Polymorphism ◽  
Cancer Patients ◽  
Gene Polymorphisms ◽  
Egfr Mutation ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Antioxidant Gene ◽  
Lung Cancer Patients

EGFR mutation status is considered as an important predictor of therapeutic responsiveness in non-small-cell lung carcinoma patients. Recent evidence suggests that antioxidant gene polymorphisms are potential predictors of lung cancer risk. Thus, stratification of EGFR mutation-related phenotypes by antioxidant gene polymorphism status can be an effective approach in terms of improving the prognosis of lung cancer patients. The present study was designed to evaluate the distribution frequency of antioxidant gene polymorphisms in lung adenocarcinoma, as well as its association with hotspot EGFR mutations. The study findings revealed that a statistically significant association exists between EGFR L858R mutation and AG + GG genotypes of SOD rs4880 polymorphism. Furthermore, the subgroup analysis data revealed that compared to AA genotype of SOD rs4880, AG + GG genotypes were significantly associated with advanced cancer stage and distant metastasis. Taken together, these findings can be utilized clinically to predict cancer aggressiveness, metastatic, potential and therapeutic responsiveness of lung cancer patients.

Investigation of FGFR4 (Gly388Arg) Gene Polymorphism in Primary Lung Cancer Patients

2015 ◽  
Vol 15 (1) ◽  
pp. 7-12 ◽  
Author(s):  
Mehmet Ture ◽  
Tahsin Yakut ◽  
Adem Deligonul ◽  
Mutlu Karkucak ◽  
Sebnem Ozemri Sag ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Gene Polymorphism ◽  
Cancer Patients ◽  
Primary Lung Cancer ◽  
Lung Cancer Patients

scholarly journals XRCC3 Gene Polymorphism Is Associated with Survival in Japanese Lung Cancer Patients

2012 ◽  
Vol 13 (12) ◽  
pp. 16658-16667 ◽  
Author(s):  
Kayo Osawa ◽  
Chiaki Nakarai ◽  
Kazuya Uchino ◽  
Masahiro Yoshimura ◽  
Noriaki Tsubota ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Gene Polymorphism ◽  
Cancer Patients ◽  
Lung Cancer Patients ◽  
Xrcc3 Gene
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