Additive Intraocular Pressure-Lowering Effects of a Novel Selective EP2 Receptor Agonist, Omidenepag Isopropyl, Combined with Existing Antiglaucoma Agents in Conscious Ocular Normotensive Monkeys

Ripasudil hydrochloride hydrate (K-115), a specific Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor, is developed for the treatment of glaucoma and ocular hypertension. Topical administration of ripasudil decreases intraocular pressure (IOP) by increasing conventional outflow through the trabeculae to Schlemm’s canal, which is different from existing agents that suppress aqueous humor production or promote uveoscleral outflow. In this study, we demonstrated that ripasudil significantly lowered IOP in combined regimens with other glaucoma therapeutic agents in rabbits and monkeys. Ripasudil showed additional effects on maximum IOP lowering or prolonged the duration of IOP-lowering effects with combined administration of timolol, nipradilol, brimonidine, brinzolamide, latanoprost, latanoprost/timolol fixed combination, and dorzolamide/timolol fixed combination. These results indicate that facilitation of conventional outflow by ripasudil provides additive IOP-lowering effect with other classes of antiglaucoma agents. Ripasudil is expected to have substantial utility in combined regimens with existing agents for glaucoma treatment.

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Oral acetazolamide for intraocular pressure lowering: balancing efficacy and safety in ophthalmic practice

Expert Review of Clinical Pharmacology ◽

10.1080/17512433.2021.1931123 ◽

2021 ◽

Author(s):

Shawn Gulati ◽

Ahmad A. Aref

Keyword(s):

Intraocular Pressure ◽

Efficacy And Safety ◽

Pressure Lowering

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Early results of micropulse transscleral cyclophotocoagulation for the treatment of glaucoma

European Journal of Ophthalmology ◽

10.1177/1120672119839303 ◽

2019 ◽

Vol 30 (4) ◽

pp. 700-705 ◽

Cited By ~ 6

Author(s):

Alexander T Nguyen ◽

Jessica Maslin ◽

Robert J Noecker

Keyword(s):

Intraocular Pressure ◽

Continuous Wave ◽

Open Angle Glaucoma ◽

Case Series ◽

Angle Closure ◽

Secondary Outcome ◽

Early Results ◽

Pressure Lowering ◽

Transscleral Cyclophotocoagulation ◽

The Mean

Purpose: To describe our clinical experience with the efficacy and safety of micropulse transscleral cyclophotocoagulation as a treatment for glaucoma. Methods: In this retrospective case series, we reviewed the charts of 95 consecutive patients with various glaucoma subtypes who underwent micropulse transscleral cyclophotocoagulation. Patients were offered micropulse transscleral cyclophotocoagulation if they had perimetric glaucoma refractory to intraocular pressure–lowering topical medications and who were poor candidates for traditional filtering surgery. Eligible patients were treated with the Micropulse P3 device (IQ 810 Laser Systems; Iridex, Mountain View, CA, USA) at 2.0–2.5 W for a duration of 90 s per hemisphere at a 31.3% duty cycle. If a retreatment was needed, the power was increased to up to 3.0 W with other parameters remaining the same. Patients were considered successfully treated if their intraocular pressure was lowered by at least 20% compared to their baseline. The main outcome measure was post-operative intraocular pressure; secondary outcome measures included the number of adverse events and complications that occurred with treatment. Results: The glaucoma subtypes treated included primary open-angle glaucoma (n = 51), exfoliation glaucoma (n = 24), chronic angle-closure glaucoma (n = 15), and congenital/juvenile glaucoma (n = 5). The mean pre-operative intraocular pressure was 25.1 ± 5.3 mm Hg and the mean post-operative intraocular pressure at 12 months was 17.5 ± 5.1 mm Hg (p = 0.004). The mean number of intraocular pressure–lowering medications used preoperatively was 3.0 ± 1.1; the mean number of medications used at the 12-month post-operative visit was 1.4 ± 1.0 (p = 0.03). Success with one treatment was achieved in 73 (76.8%) of patients. With multiple treatments, all patients had significant intraocular pressure–lowering compared to baseline. The maximum number of treatments received by any single patient was 5. There were no instances of prolonged intraocular inflammation or long-term hypotony. Conclusion: Micropulse transscleral cyclophotocoagulation appears to be a safe and efficacious treatment for glaucoma. Given its improved safety profile compared to continuous-wave transscleral cyclophotocoagulation, it deserves consideration as a primary procedure.

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Association between Rates of Retinal Nerve Fiber Layer Thinning after Intraocular Pressure–Lowering Procedures and Disc Hemorrhage

Ophthalmology Glaucoma ◽

10.1016/j.ogla.2019.11.002 ◽

2020 ◽

Vol 3 (1) ◽

pp. 7-13 ◽

Cited By ~ 2

Author(s):

Huiyuan Hou ◽

Sasan Moghimi ◽

Linda M. Zangwill ◽

James A. Proudfoot ◽

Tadamichi Akagi ◽

...

Keyword(s):

Intraocular Pressure ◽

Nerve Fiber ◽

Retinal Nerve Fiber Layer ◽

Fiber Layer ◽

Disc Hemorrhage ◽

Nerve Fiber Layer ◽

Pressure Lowering ◽

Retinal Nerve Fiber

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Carbonic anhydrase inhibitors – part 70. Synthesis and ocular pharmacology of a new class of water-soluble, topically effective intraocular pressure lowering agents derived from nicotinic acid and aromatic/heterocyclic sulfonamides

European Journal of Medicinal Chemistry ◽

10.1016/s0223-5234(99)00212-3 ◽

1999 ◽

Vol 34 (10) ◽

pp. 799-808 ◽

Cited By ~ 9

Author(s):

C Supuran

Keyword(s):

Intraocular Pressure ◽

Carbonic Anhydrase ◽

Nicotinic Acid ◽

Water Soluble ◽

Carbonic Anhydrase Inhibitors ◽

New Class ◽

Pressure Lowering ◽

Aromatic Heterocyclic ◽

Ocular Pharmacology

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Intraocular Pressure-Lowering Potential of Subthreshold Selective Laser Trabeculoplasty in Patients with Primary Open-Angle Glaucoma

Journal of Ophthalmology ◽

10.1155/2016/2153723 ◽

2016 ◽

Vol 2016 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Hong Yang Zhang ◽

Yong Jie Qin ◽

Yang Fan Yang ◽

Jian Gang Xu ◽

Min Bin Yu

Keyword(s):

Intraocular Pressure ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Initial Energy ◽

The Other ◽

Open Angle ◽

Selective Laser Trabeculoplasty ◽

Laser Trabeculoplasty ◽

Pressure Lowering ◽

Laser Flare

Purpose.To compare the efficacy of subthreshold and conventional selective laser trabeculoplasty (SLT) in lowering intraocular pressure (IOP) in the patients with primary open-angle glaucoma (POAG).Methods.Fifty-two eyes from fifty-two POAG patients were randomized into two groups, one group treated with subthreshold SLT using two-thirds of the conventional energy and the other one treated with the conventional energy. IOP was measured with the Goldmann tonometer and the anterior chamber inflammation was determined using laser flare meter.Results.The initial energy dosage used in subthreshold SLT group was significantly lower than the amount of the energy used in conventional SLT group (0.4±0.1 mJ versus0.6±0.1 mJ,P=0.030). The total energy dosage was also significantly lower in subthreshold SLT group compared to the other group (37.6±3.3 mJ versus51.8±5.7 mJ,P=0.036). However, the level of inflammation in aqueous humor, amount of reduction in IOP, and the success rate in controlling IOP was the same in both groups.Conclusion.The efficacy of subthreshold SLT group in reducing IOP in POAG patients is comparable to the efficacy of conventional SLT group.

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