Recovery of Water Maze Performance in Aged Versus Young Rats After Brain Injury With the Impact Acceleration Model

2000 ◽  
Vol 17 (12) ◽  
pp. 1141-1153 ◽  
Author(s):  
PETER H. MAUGHAN ◽  
KEVIN J. SCHOLTEN ◽  
RICHARD H. SCHMIDT
Keyword(s):  
Brain Injury ◽  
Water Maze ◽  
Maze Performance ◽  
Young Rats ◽  
Acceleration Model ◽  
Impact Acceleration ◽  
The Impact

Nefiracetam improves Morris water maze performance following traumatic brain injury in rats

2001 ◽  
Vol 69 (3-4) ◽  
pp. 611-616 ◽  
Author(s):  
S.Michelle DeFord ◽  
Margaret S Wilson ◽  
Cynthia J Gibson ◽  
Anya Baranova ◽  
Robert J Hamm
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Morris Water Maze ◽  
Water Maze ◽  
Maze Performance

The impact-acceleration model of head injury: Injury severity predicts motor and cognitive performance after trauma

1999 ◽  
Vol 21 (8) ◽  
pp. 742-754 ◽  
Author(s):  
Andrew Beaumont ◽  
Anthony Marmarou ◽  
Andrea Czigner ◽  
Mazayuki Yamamoto ◽  
Kate Demetriadou ◽  
...  
Keyword(s):  
Head Injury ◽  
Cognitive Performance ◽  
Injury Severity ◽  
Acceleration Model ◽  
Impact Acceleration ◽  
The Impact

scholarly journals Analysis and Experimental Study of Acceleration Model for Short Interval and Multiple Impact Equipment

2019 ◽  
Vol 2019 ◽  
pp. 1-15
Author(s):  
Feiyin Li ◽  
Shaojie Ma
Keyword(s):  
Stress Wave ◽  
Short Interval ◽  
High Impact ◽  
Line Contact ◽  
Acceleration Model ◽  
Impact Experiment ◽  
Impact Acceleration ◽  
Multiple Impact ◽  
The Impact ◽  
Impact Experiments

Short interval and continuous high-impact experiments have very significant engineering application values, and impact acceleration is a key performance index of these dynamic experiments. This paper aims at the shortcomings of the existing multiple high-impact equipment, designs a new type of multiple high-impact equipment based on the collision contact mode by multiple impact components, and studies the composition of acceleration in impact experiment. The research results indicate that it is unreasonable to analyze the impact acceleration only based on rigid body dynamics theory and ignore the effect of the stress wave loading during an impact experiment. On this basis, a line contact model is adopted to modify the equivalent damping coefficient and obtain a nonlinear spring damping contact force model based on the line contact, and then a rigid body acceleration model of the impact experiment is established. A stress wave acceleration model is also established based on the one-dimensional stress wave transfer theory of the tested specimen. The established acceleration model is verified by different corresponding impact experiments. At the same time, the collision contact process of the impact experiment is also simulated which is combined with the finite element method. The simulation results were fundamentally consistent with the experiments and a fact that proves the correctness of analysis and modeling. The research results not only provide theoretical support for the design and analysis of the impact equipment and a new idea to realize multiple high-impact loading but also provide a methodology to be applied to the analysis and modeling of acceleration for similar high-impact experiments.

Chronic methylphenidate treatment enhances water maze performance following traumatic brain injury in rats

2000 ◽  
Vol 280 (3) ◽  
pp. 163-166 ◽  
Author(s):  
Anthony E Kline ◽  
Hong Q Yan ◽  
Juliang Bao ◽  
Donald W Marion ◽  
C.Edward Dixon
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Water Maze ◽  
Maze Performance

The Immunophilin Ligand FK506 Attenuates Axonal Injury in an Impact-Acceleration Model of Traumatic Brain Injury

2001 ◽  
Vol 18 (6) ◽  
pp. 607-614 ◽  
Author(s):  
Richard H. Singleton ◽  
James R. Stone ◽  
David O. Okonkwo ◽  
Anthony J. Pellicane ◽  
John T. Povlishock
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Axonal Injury ◽  
Acceleration Model ◽  
Impact Acceleration

Impact Acceleration Model of Diffuse Traumatic Brain Injury

2016 ◽  
pp. 253-266 ◽  
Author(s):  
Sarah C. Hellewell ◽  
Jenna M. Ziebell ◽  
Jonathan Lifshitz ◽  
M. Cristina Morganti-Kossmann
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Acceleration Model ◽  
Impact Acceleration

Local Administration of the Poly(ADP-Ribose) Polymerase Inhibitor INO-1001 Prevents NAD+ Depletion and Improves Water Maze Performance after Traumatic Brain Injury in Mice

2007 ◽  
Vol 24 (8) ◽  
pp. 1399-1405 ◽  
Author(s):  
Robert S.B. Clark ◽  
Vincent A. Vagni ◽  
Paula D. Nathaniel ◽  
Larry W. Jenkins ◽  
C. Edward Dixon ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Water Maze ◽  
Local Administration ◽  
Maze Performance ◽  
Polymerase Inhibitor ◽  
Nad Depletion

Neuropharmacological and neurochemical evaluation of N-n-propyl-3-ethoxyquinoxaline-2-carboxamide (6n): a novel serotonergic 5-HT3 receptor antagonist for co-morbid antidepressant- and anxiolytic-like potential using traumatic brain injury model in rats

2017 ◽  
Vol 28 (2) ◽  
Author(s):  
Shvetank Bhatt ◽  
Radhakrishnan Mahesh ◽  
Ankur Jindal ◽  
Thangaraj Devadoss
Keyword(s):  
Depression And Anxiety ◽  
Sucrose Consumption ◽  
Injury Model ◽  
Plus Maze ◽  
Marble Burying ◽  
Acceleration Model ◽  
Steel Disc ◽  
Impact Acceleration ◽  
The Impact ◽  
Scalp Incision

AbstractBackground:Several preclinical studies have shown that serotonergic 5-HTMethods:In this model, a 1 cm midline scalp incision was made, and the muscles were retracted to expose the skull. A stainless steel disc (10 mm in diameter and 3 mm in depth) was placed centrally between the lambda and bregma regions. The injury was induced using the impact acceleration model of TBI. Specifically, a 400 g metal weight was dropped from a height of 1 m guided by a straight pipe, onto the metal disc placed over the rat’s skull.Results:The behavioral anomalies of the TBI rats were attenuated by the chronic treatment of compound 6n (1 and 2 mg/kg, p.o.; 14 days) as observed by the modified open field test (ambulation, rearing, and fecal pellet), sucrose consumption test (% sucrose consumption), elevated plus maze [% open arm entries [OAE] and % time spent in open arm (TSOA)], and marble burying test (numbers). In addition, 6n also increased the levels of neurotransmitters (norepinephrine and serotonin) and brain derived neurotrophic factor (BDNF) in TBI rats.Conclusions:The result suggests that compound 6n exhibited antidepressant- and anxiolytic-like effects in rodent models of depression and anxiety.

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