Spinal Cord Injury Leads to Hyperoxidation and Nitrosylation of Skeletal Muscle Ryanodine Receptor-1 Associated with Upregulation of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4

2017 ◽  
Vol 34 (12) ◽  
pp. 2069-2074 ◽  
Author(s):  
Xin-Hua Liu ◽  
Lauren Harlow ◽  
Zachary A. Graham ◽  
William A. Bauman ◽  
Christopher Cardozo
Keyword(s):  
Skeletal Muscle ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Ryanodine Receptor ◽  
Nicotinamide Adenine Dinucleotide ◽  
Nicotinamide Adenine Dinucleotide Phosphate ◽  
Nicotinamide Adenine ◽  
Cord Injury ◽  
Ryanodine Receptor 1

scholarly journals Neuroprotective effects of P7C3 against spinal cord injury in rats

2019 ◽  
Vol 244 (18) ◽  
pp. 1680-1687
Author(s):  
Fei-Xiang Duan ◽  
Yu-Jiao Shi ◽  
Jing Chen ◽  
Shu-Qin Ding ◽  
Feng-Chao Wang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Nicotinamide Adenine Dinucleotide ◽  
Neurological Outcome ◽  
Neurological Disease ◽  
Tissue Repair ◽  
Therapeutic Interventions ◽  
Nicotinamide Adenine ◽  
Cord Injury

Spinal cord injury (SCI), a serious neurological disease, has few therapeutic interventions. A small molecule, P7C3, has been confirmed to play a role in neuroprotection of some neurological diseases. But the effect of P7C3 on acute SCI has not been investigated. Here, we observed the therapeutic effect of P7C3 for alleviating the neurological damage by direct subcutaneous injection after SCI once daily for 7 or 14 days in a rat model. The locomotion and histopathological changes were evaluated. Our results demonstrated that P7C3 treatment contributed to functional recovery and tissue repair following SCI. Improved locomotor function with P7C3 treatment was correlated with increased survival of neurons and oligodendrocytes (OLs) and proliferation of OLs and their progenitors, which resulted in tissue repair and myelination in the injured SC. P7C3 treatment also restored the nicotinamide adenine dinucleotide level in the SC, which was reduced by SCI. These results suggest that P7C3 plays a role in improving neurological outcome following SCI. Impact statement Spinal cord injury (SCI), a serious neurological disease, has few therapeutic interventions. This study confirms for the first time that P7C3 is conducive to functional recovery and tissue repair after SCI. P7C3 treatment can rescue the nicotinamide adenine dinucleotide level of the injured spinal cord, which results in more survival of neurons and oligodendrocytes (OLs) and proliferation of OLs and their progenitors, and thus increase myelination and tissue repair. This result indicates that P7C3 plays a role in improving neurological outcome following SCI.

scholarly journals Protein translation, proteolysis and autophagy in human skeletal muscle atrophy after spinal cord injury

2018 ◽  
Vol 223 (3) ◽  
pp. e13051 ◽  
Author(s):  
L. S. Lundell ◽  
M. Savikj ◽  
E. Kostovski ◽  
P. O. Iversen ◽  
J. R. Zierath ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Muscle Atrophy ◽  
Human Skeletal Muscle ◽  
Protein Translation ◽  
Skeletal Muscle Atrophy ◽  
Cord Injury

Skeletal Muscle Size, Intramuscular Fat and Spasticity after Incomplete Spinal Cord Injury (SCI)

2004 ◽  
Vol 36 (Supplement) ◽  
pp. S35-S36
Author(s):  
Ashraf S. Gorgey ◽  
Christopher S. Bickel ◽  
Leslie R. VanHiel ◽  
Gary A. Dudley
Keyword(s):  
Skeletal Muscle ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Intramuscular Fat ◽  
Muscle Size ◽  
Incomplete Spinal Cord Injury ◽  
Cord Injury

Skeletal Muscle Morphology after Incomplete Spinal Cord Injury

2006 ◽  
Vol 38 (Supplement) ◽  
pp. S51-S52 ◽  
Author(s):  
Prithvi K. Shah ◽  
Jennifer E. Stevens ◽  
Chris M. Gregory ◽  
Neeti C. Pathare ◽  
Arun Jayaraman ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Incomplete Spinal Cord Injury ◽  
Muscle Morphology ◽  
Cord Injury

The Effect of Treadmill Training on IGF-I Expression in Skeletal Muscle Following Spinal Cord Injury

2006 ◽  
Vol 38 (Supplement) ◽  
pp. S61
Author(s):  
Min Liu ◽  
Jennifer E. Stevens ◽  
Prodip Bose ◽  
Floyd J. Thompson ◽  
Wilbur Oʼsteen ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Treadmill Training ◽  
Cord Injury ◽  
Igf I

The Effect Of Treadmill Training On Igf-1 Levels In Rat Skeletal Muscle And Lumbar Spinal Cord Following Spinal Cord Injury

2007 ◽  
Vol 39 (Supplement) ◽  
pp. S313
Author(s):  
Min Liu ◽  
Jennifer E. Stevens ◽  
Glenn A. Walter ◽  
Prodip Bose ◽  
Floyd J. Thompson ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Treadmill Training ◽  
Lumbar Spinal Cord ◽  
Rat Skeletal Muscle ◽  
Cord Injury ◽  
Lumbar Spinal
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