Glial Cell Line-Derived Neurotrophic Factor (GDNF) Is a Proliferation Factor for Rat C6 Glioma Cells: Evidence from Antisense Experiments

2000 ◽  
Vol 10 (5) ◽  
pp. 311-321 ◽  
Author(s):  
BETTINA WIESENHOFER ◽  
CARLA WEIS ◽  
CHRISTIAN HUMPEL
Keyword(s):  
Cell Line ◽  
Glial Cell ◽  
Neurotrophic Factor ◽  
Glioma Cells ◽  
C6 Glioma ◽  
C6 Glioma Cells ◽  
Rat C6 Glioma

Retinoids Induce t-PA Synthesis by C6 Glioma Cells -Role in Tumoral Haemorrhagic Necrosis

1996 ◽  
Vol 75 (02) ◽  
pp. 332-338 ◽  
Author(s):  
Gilles Pernod ◽  
Guy Amalfltano ◽  
Brigitte Le Magueresse ◽  
Francois Berger ◽  
Benolt Polack ◽  
...  
Keyword(s):  
Cell Line ◽  
Fibrinolytic Activity ◽  
Glioma Cells ◽  
C6 Glioma ◽  
C6 Glioma Cells ◽  
C6 Cell Line ◽  
Haemorrhagic Necrosis ◽  
Retinoid Treatment ◽  
Rat C6 Glioma

SummaryTreatment of rat C6 glioma with high doses of 13 cis-retinoic acid (cRA) was responsible for death related to haemorrhagic necrosis localized to the tumor. Our aim was to explore this adverse effect of retinoid treatment. We show that cRA-treated C6 glioma at 25 mg/kg/day for 18 days exhibits in vivo an increased t-PA activity, which is responsible for a localized tumor fibrinolytic activity. Production of t-PA is supported by specific enhancement of gene expression, as was shown by the increase in t-PA mRNA (X 2.3). This production is a direct effect of cRA when treating the tumor, since tumor cells themself do not produce enough t-PA and treatment of control rats does not increase the t-PA level. t-PA production by rat C6 glioma is in vivo related to the specific synthesis of t-PA by the C6 cell-line. The stimulation of C6 cell-line by cRA in vitro is dose-dependent and reached a maximum for 3 and 30 |iM at the 72nd h. So cRA-treated C6 glioma cells produce t-PA which appears to be the major species associated with the fibrinolytic activity-induced intra-tumoral haemorrhage after exposure to retinoid treatment.

scholarly journals Impact of calcitriol and an AKT inhibitor, AT7867, on survival of rat C6 glioma cells

2021 ◽  
Vol 35 (1) ◽  
pp. 730-738
Author(s):  
Ozlem Kucukhuseyin ◽  
Aris Cakiris ◽  
Mehmet Tolgahan Hakan ◽  
Cem Horozoglu ◽  
Erdem Tuzun ◽  
...  
Keyword(s):  
Glioma Cells ◽  
C6 Glioma ◽  
C6 Glioma Cells ◽  
Akt Inhibitor ◽  
Rat C6 Glioma
Sign in / Sign up

Export Citation Format

Share Document