Metabolomics for Animal Models of Rare Human Diseases: An Expert Review and Lessons Learned

2019 ◽  
Vol 23 (6) ◽  
pp. 300-307
Author(s):  
Kalle Kilk
Keyword(s):  
Animal Models ◽  
Lessons Learned ◽  
Human Diseases ◽  
Expert Review

scholarly journals Monkey Models of Tuberculosis: Lessons Learned

2014 ◽  
Vol 83 (3) ◽  
pp. 852-862 ◽  
Author(s):  
Juliet C. Peña ◽  
Wen-Zhe Ho
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Animal Models ◽  
Nonhuman Primates ◽  
Lessons Learned ◽  
Preclinical Testing ◽  
Content Type ◽  
Cynomolgus Macaques ◽  
Drug Regimens

The use of animal models has been invaluable for studying the pathogenesis ofMycobacterium tuberculosisinfection, as well as for testing the efficacy of vaccines and drug regimens for tuberculosis. Among the applied animal models, nonhuman primates, particularly macaques, share the greatest anatomical and physiological similarities with humans. As such, macaque models have been used for investigating tuberculosis pathogenesis and preclinical testing of drugs and vaccines. This review focuses on published major studies which illustrate how the rhesus and cynomolgus macaques have enriched and may continue to advance the field of global tuberculosis research.

scholarly journals Breathing challenges in Rett Syndrome: Lessons learned from humans and animal models

2013 ◽  
Vol 189 (2) ◽  
pp. 280-287 ◽  
Author(s):  
Jan-Marino Ramirez ◽  
Christopher Scott Ward ◽  
Jeffrey Lorenz Neul
Keyword(s):  
Animal Models ◽  
Rett Syndrome ◽  
Lessons Learned

scholarly journals New approaches to the representation and analysis of phenotype knowledge in human diseases and their animal models

2011 ◽  
Vol 10 (5) ◽  
pp. 258-265 ◽  
Author(s):  
P. N. Schofield ◽  
J. P. Sundberg ◽  
R. Hoehndorf ◽  
G. V. Gkoutos
Keyword(s):  
Animal Models ◽  
Human Diseases ◽  
New Approaches

Sensors for Proteolytic Activity Visualization and Their Application in Animal Models of Human Diseases

2019 ◽  
Vol 84 (S1) ◽  
pp. 1-18
Author(s):  
A. A. Bogdanov ◽  
I. D. Solovyev ◽  
A. P. Savitsky
Keyword(s):  
Animal Models ◽  
Proteolytic Activity ◽  
Human Diseases

Translational research of novel hormones: lessons from animal models and rare human diseases for common human diseases

2009 ◽  
Vol 87 (10) ◽  
pp. 1029-1039 ◽  
Author(s):  
Kazuwa Nakao ◽  
Akihiro Yasoda ◽  
Ken Ebihara ◽  
Kiminori Hosoda ◽  
Masashi Mukoyama
Keyword(s):  
Animal Models ◽  
Translational Research ◽  
Human Diseases
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