Impact of Intracranial Pressure Monitor Prophylaxis on Central Nervous System Infections and Bacterial Multi-Drug Resistance

2008 ◽  
Vol 9 (5) ◽  
pp. 503-508 ◽  
Author(s):  
Nathaniel F. Stoikes ◽  
Louis J. Magnotti ◽  
Timothy M. Hodges ◽  
Jordan A. Weinberg ◽  
Thomas J. Schroeppel ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Drug Resistance ◽  
Nervous System ◽  
Intracranial Pressure ◽  
Multi Drug Resistance ◽  
Central Nervous System Infections ◽  
Pressure Monitor

Intracranial pressure in childhood central nervous system infections

1988 ◽  
Vol 14 (5) ◽  
pp. 522-525 ◽  
Author(s):  
P. Rebaud ◽  
J. C. Berthier ◽  
E. Hartemann ◽  
D. Floret
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Intracranial Pressure ◽  
Central Nervous System Infections

scholarly journals Multi-drug resistance gene (MDR1) and opioid analgesia in horses

2006 ◽  
Vol 36 (1) ◽  
pp. 330-335 ◽  
Author(s):  
Cláudio Corrêa Natalini ◽  
Anderson Fávaro da Cunha ◽  
Renata Lehn Linardi
Keyword(s):  
Central Nervous System ◽  
Drug Resistance ◽  
Nervous System ◽  
Resistance Gene ◽  
Opioid Analgesic ◽  
Mdr1 Gene ◽  
Neuronal Uptake ◽  
Multi Drug Resistance ◽  
Drug Resistance Gene ◽  
The Central Nervous System

Opioid absorption in the intestinal tract as well as its effects in the central nervous system is modulated by the P-glycoprotein (P-gp) encoded in the Multi-drug Resistance gene (MDR1) also named ATP-binding cassete, subfamily B, member 1 (ABCB1). This MDR1 gene acts as a selective pump. The expression of this protein in humans and rodents inhibits cellular uptake of substrate opioids. The presence of the intestinal iso-enzyme CYP3A4 associated with MDR1 gene decreases the opioid analgesic activity due to an increase in intestinal metabolism, with a predicted intestinal first pass extraction around 20% which significantly influences the oral availability of opioids. In the central nervous system, P-gp expression decreases opioid neuronal uptake diminishing the analgesic effects. It is unknown if horses have the MDR1 gene and P-gp and what are the effects on opioid absorption, metabolism, and analgesia. Identifying the MDR1 gene and P-gp status in horses is of great importance in order to better understand opioid pharmacologic effects in horses.

scholarly journals Intrathecal Colistin and Intravenous Fosfomycin as a combination therapy for the treatment of Acinetobacter baumannii Ventriculitis and meningitis: a case report from Nepal

2021 ◽  
Vol 18 (4) ◽  
pp. 39-43
Author(s):  
Bikash Khadka ◽  
Saroj Poudel
Keyword(s):  
Central Nervous System ◽  
Drug Resistance ◽  
Nervous System ◽  
Acinetobacter Baumannii ◽  
Central Nervous System Infection ◽  
Multi Drug Resistance ◽  
Intraventricular Administration ◽  
Successful Management ◽  
Initial Regimen ◽  
Cns Penetration

Treatment of central nervous system infection may be troublesome due to multi-drug resistance. Colistin is less successful as a treatment option due to poor CNS penetration when used intravenously. We present the successful management of a case with ventriculitis and meningitis due to MDR Acinetobacter baumannii species with the combined intraventricular administration of colistin and IV fosfomycin after the initial regimen of colistin given alone through both IVT and IV routes had failed.

Management of central nervous system infections during an epidemic of enteroviral aseptic meningitis

1980 ◽  
Vol 96 (3) ◽  
pp. 559-563 ◽  
Author(s):  
Jonathan I. Singer ◽  
Philip R. Maur ◽  
John P. Riley ◽  
Pamela Burger Smith
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Aseptic Meningitis ◽  
Central Nervous System Infections

Diffusion imaging in pediatric central nervous system infections

2001 ◽  
Vol 43 (12) ◽  
pp. 1031-1039 ◽  
Author(s):  
J. Teixeira ◽  
R. Zimmerman ◽  
J. Haselgrove ◽  
L. Bilaniuk ◽  
J. Hunter
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Diffusion Imaging ◽  
Central Nervous System Infections
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