Clinical Translation of Cell Therapy, Tissue Engineering, and Regenerative Medicine Product in Malaysia and Its Regulatory Policy

The intervertebral disc hernia is distinguished one of the diseases of the human locomotor apparatus that causes pain, neurological deficit and functional disorders.Inefficency of concervative treatment and repeated appeals for medical help after surgery have urged on the need for exploration of some new more effective methods of treatment aimed not only at weakening degenerative processes and pain but also at renewing disc function and its height maintenance. Achievements of regenerative medicine and tissue engineering promote development of new efficient methods of cell therapy. The results of their application in experimental studies on animals give us hope for their successful use in humans.

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Role of stem cell therapy in orthopaedic tissue engineering and regenerative medicine: a comprehensive review of the literature from basic to clinical application

Hard Tissue ◽

10.13172/2050-2303-2-4-547 ◽

2013 ◽

Vol 2 (4) ◽

Cited By ~ 3

Author(s):

A Moshiri ◽

A Oryan ◽

A Meimandi-Parizi

Keyword(s):

Tissue Engineering ◽

Stem Cell ◽

Regenerative Medicine ◽

Cell Therapy ◽

Clinical Application ◽

Stem Cell Therapy ◽

Review Of The Literature ◽

Comprehensive Review

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The early career researcher's toolkit: translating tissue engineering, regenerative medicine and cell therapy products

Regenerative Medicine ◽

10.2217/rme.15.56 ◽

2015 ◽

Vol 10 (8) ◽

pp. 989-1003 ◽

Cited By ~ 3

Author(s):

Qasim A Rafiq ◽

Ilida Ortega ◽

Stuart I Jenkins ◽

Samantha L Wilson ◽

Asha K Patel ◽

...

Keyword(s):

Tissue Engineering ◽

Regenerative Medicine ◽

Cell Therapy ◽

Early Career

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Hurdles in Tissue Engineering/Regenerative Medicine Product Commercialization: A Survey of North American Academia and Industry

Tissue Engineering Part A ◽

10.1089/ten.tea.2010.0411 ◽

2011 ◽

Vol 17 (1-2) ◽

pp. 5-15 ◽

Cited By ~ 28

Author(s):

Peter C. Johnson ◽

Timothy A. Bertram ◽

Bill Tawil ◽

Kiki B. Hellman

Keyword(s):

Tissue Engineering ◽

Regenerative Medicine ◽

North American ◽

American Academia ◽

Medicine Product

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Microfluidic-Based Droplets for Advanced Regenerative Medicine: Current Challenges and Future Trends

Biosensors ◽

10.3390/bios12010020 ◽

2021 ◽

Vol 12 (1) ◽

pp. 20

Author(s):

Hojjatollah Nazari ◽

Asieh Heirani-Tabasi ◽

Sadegh Ghorbani ◽

Hossein Eyni ◽

Sajad Razavi Bazaz ◽

...

Keyword(s):

Tissue Engineering ◽

Stem Cells ◽

Regenerative Medicine ◽

Cell Therapy ◽

Large Scale ◽

Three Dimensional ◽

3D Culture ◽

Cell Encapsulation ◽

Cost Effective ◽

Culture Methods

Microfluidics is a promising approach for the facile and large-scale fabrication of monodispersed droplets for various applications in biomedicine. This technology has demonstrated great potential to address the limitations of regenerative medicine. Microfluidics provides safe, accurate, reliable, and cost-effective methods for encapsulating different stem cells, gametes, biomaterials, biomolecules, reagents, genes, and nanoparticles inside picoliter-sized droplets or droplet-derived microgels for different applications. Moreover, microenvironments made using such droplets can mimic niches of stem cells for cell therapy purposes, simulate native extracellular matrix (ECM) for tissue engineering applications, and remove challenges in cell encapsulation and three-dimensional (3D) culture methods. The fabrication of droplets using microfluidics also provides controllable microenvironments for manipulating gametes, fertilization, and embryo cultures for reproductive medicine. This review focuses on the relevant studies, and the latest progress in applying droplets in stem cell therapy, tissue engineering, reproductive biology, and gene therapy are separately evaluated. In the end, we discuss the challenges ahead in the field of microfluidics-based droplets for advanced regenerative medicine.

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Applications and Implications of Heparin and Protamine in Tissue Engineering and Regenerative Medicine

BioMed Research International ◽

10.1155/2014/936196 ◽

2014 ◽

Vol 2014 ◽

pp. 1-10 ◽

Cited By ~ 9

Author(s):

Judee Grace E. Nemeno ◽

Soojung Lee ◽

Wojong Yang ◽

Kyung Mi Lee ◽

Jeong Ik Lee

Keyword(s):

Tissue Engineering ◽

Stem Cell ◽

Regenerative Medicine ◽

Cell Therapy ◽

Signaling Pathways ◽

Stem Cell Therapy ◽

Drug Repositioning ◽

Historical Background ◽

Fields Of Study ◽

Therapeutic Uses

Drug repositioning is one of the most rapidly emerging fields of study. This concept is anchored on the principle that diseases have similar damaged or affected signaling pathways. Recently, drugs have been repositioned not only for their alternative therapeutic uses but also for their applications as biomaterials in various fields. However, medical drugs as biomaterials are rarely focused on in reviews. Fragmin and protamine have been recently the sources of increasing attention in the field of tissue engineering and regenerative medicine. Fragmin and protamine have been manufactured primarily as a safe antidote for the circulating heparin. Lately, these drugs have been utilized as either micro- or nanoparticle biomaterials. In this paper, we will briefly describe the concept of drug repositioning and some of the medical drugs that have been repurposed for their alternative therapeutic uses. Also, this will feature the historical background of the studies focused on fragmin/protamine micro/nanoparticles (F/P M/NPs) and their applications as biomaterials in tissue engineering, stem cell therapy, and regenerative medicine.

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