scholarly journals Abundances of transcripts, proteins, and metabolites in the cell cycle of budding yeast reveal coordinate control of lipid metabolism

2020 ◽  
Vol 31 (10) ◽  
pp. 1069-1084 ◽  
Author(s):  
Heidi M. Blank ◽  
Ophelia Papoulas ◽  
Nairita Maitra ◽  
Riddhiman Garge ◽  
Brian K. Kennedy ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Lipid Metabolism ◽  
Cell Division ◽  
Yeast Cell ◽  
Budding Yeast ◽  
Yeast Cells ◽  
Dynamic Changes ◽  
Coordinate Control ◽  
Cycle Dependent ◽  
Budding Yeast Cell Cycle

In several systems, including budding yeast, cell cycle-dependent changes in the transcriptome are well studied. In contrast, few studies queried the proteome during cell division. There is also little information about dynamic changes in metabolites and lipids in the cell cycle. Here, the authors present such information for dividing yeast cells.

scholarly journals Abundances of transcripts, proteins, and metabolites in the cell cycle of budding yeast reveals coordinate control of lipid metabolism

2019 ◽  
Author(s):  
Heidi M. Blank ◽  
Ophelia Papoulas ◽  
Nairita Maitra ◽  
Riddhiman Garge ◽  
Brian K. Kennedy ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Lipid Metabolism ◽  
Cell Division ◽  
Ribosome Biogenesis ◽  
Budding Yeast ◽  
Eukaryotic Cell ◽  
Yeast Cells ◽  
Protein Levels ◽  
Coordinate Control ◽  
Cycle Dependent

ABSTRACTEstablishing the pattern of abundance of molecules of interest during cell division has been a long-standing goal of cell cycle studies. In several systems, including the budding yeast Saccharomyces cerevisiae, cell cycle-dependent changes in the transcriptome are well studied. In contrast, few studies queried the proteome during cell division, and they are often plagued by low agreement with each other and with previous transcriptomic datasets. There is also little information about dynamic changes in the levels of metabolites and lipids in the cell cycle. Here, for the first time in any system, we present experiment-matched datasets of the levels of RNAs, proteins, metabolites, and lipids from un-arrested, growing, and synchronously dividing yeast cells. Overall, transcript and protein levels were correlated, but specific processes that appeared to change at the RNA level (e.g., ribosome biogenesis), did not do so at the protein level, and vice versa. We also found no significant changes in codon usage or the ribosome content during the cell cycle. We describe an unexpected mitotic peak in the abundance of ergosterol and thiamine biosynthesis enzymes. Although the levels of several metabolites changed in the cell cycle, by far the most significant changes were in the lipid repertoire, with phospholipids and triglycerides peaking strongly late in the cell cycle. Our findings provide an integrated view of the abundance of biomolecules in the eukaryotic cell cycle and point to a coordinate mitotic control of lipid metabolism.

scholarly journals Optimization and model reduction in the high dimensional parameter space of a budding yeast cell cycle model

2013 ◽  
Vol 7 (1) ◽  
pp. 53 ◽  
Author(s):  
Cihan Oguz ◽  
Teeraphan Laomettachit ◽  
Katherine C Chen ◽  
Layne T Watson ◽  
William T Baumann ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Yeast Cell ◽  
Model Reduction ◽  
Parameter Space ◽  
Budding Yeast ◽  
Yeast Cell Cycle ◽  
High Dimensional ◽  
Cycle Model ◽  
Dimensional Parameter ◽  
Budding Yeast Cell Cycle

scholarly journals Monitoring of the Budding Yeast Cell Cycle Using Electrical Parameters

IEEE Access ◽  
2018 ◽  
Vol 6 ◽  
pp. 19231-19237 ◽  
Author(s):  
Mahmoud Al Ahmad ◽  
Zeina Al Natour ◽  
Samir Attoub ◽  
Ahmed H. Hassan
Keyword(s):  
Cell Cycle ◽  
Yeast Cell ◽  
Budding Yeast ◽  
Yeast Cell Cycle ◽  
Electrical Parameters ◽  
Budding Yeast Cell Cycle

scholarly journals A hybrid stochastic model of the budding yeast cell cycle

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Mansooreh Ahmadian ◽  
John J. Tyson ◽  
Jean Peccoud ◽  
Yang Cao
Keyword(s):  
Cell Cycle ◽  
Stochastic Model ◽  
Yeast Cell ◽  
Budding Yeast ◽  
Yeast Cell Cycle ◽  
Budding Yeast Cell Cycle

scholarly journals Fragilities Caused by Dosage Imbalance in Regulation of the Budding Yeast Cell Cycle

PLoS Genetics ◽  
2010 ◽  
Vol 6 (4) ◽  
pp. e1000919 ◽  
Author(s):  
Kazunari Kaizu ◽  
Hisao Moriya ◽  
Hiroaki Kitano
Keyword(s):  
Cell Cycle ◽  
Yeast Cell ◽  
Budding Yeast ◽  
Yeast Cell Cycle ◽  
Dosage Imbalance ◽  
Budding Yeast Cell Cycle

scholarly journals A Mathematical Programming Formulation for the Budding Yeast Cell Cycle

SIMULATION ◽  
2007 ◽  
Vol 83 (7) ◽  
pp. 497-514
Author(s):  
Thomas D. Panning ◽  
Layne T. Watson ◽  
Clifford A. Shaffer ◽  
John J. Tyson
Keyword(s):  
Cell Cycle ◽  
Mathematical Programming ◽  
Yeast Cell ◽  
Budding Yeast ◽  
Yeast Cell Cycle ◽  
Programming Formulation ◽  
Mathematical Programming Formulation ◽  
Budding Yeast Cell Cycle

scholarly journals Evidence that a free-running oscillator drives G1 events in the budding yeast cell cycle

Nature ◽  
10.1038/43927 ◽  
1999 ◽  
Vol 401 (6751) ◽  
pp. 394-397 ◽  
Author(s):  
Steven B. Haase ◽  
Steven I. Reed
Keyword(s):  
Cell Cycle ◽  
Yeast Cell ◽  
Budding Yeast ◽  
Yeast Cell Cycle ◽  
Free Running ◽  
Budding Yeast Cell Cycle
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