Transcutaneous Lumbar Posterior Root Stimulation for Motor Control Studies and Modification of Motor Activity after Spinal Cord Injury

2011 ◽  
pp. 226-255 ◽  
Author(s):  
Karen Minassian ◽  
Ursula Hofstoetter ◽  
Frank Rattay
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Motor Control ◽  
Motor Activity ◽  
Posterior Root ◽  
Cord Injury ◽  
Root Stimulation

scholarly journals Results of the Treatment of Neurogenic Bladder Dysfunction in Spinal Cord Injury by Sacral Posterior Root Rhizotomy and Anterior Sacral Root Stimulation

1996 ◽  
Vol 155 (4) ◽  
pp. 1378-1381 ◽  
Author(s):  
Philip E.V. Van Kerrebroeck ◽  
Evert L. Koldewijn ◽  
Peter F.W.M. Rosier ◽  
Hessel Wijkstra ◽  
Frans M.J. Debruyne
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neurogenic Bladder ◽  
Bladder Dysfunction ◽  
Posterior Root ◽  
Neurogenic Bladder Dysfunction ◽  
Cord Injury ◽  
Root Stimulation

scholarly journals Selective Detrusor Activation By Electrical Sacral Nerve Root Stimulation in Spinal Cord Injury

1997 ◽  
Vol 157 (4) ◽  
pp. 1504-1508 ◽  
Author(s):  
N.J.M. Rijkhoff ◽  
H. Wijkstra ◽  
P.E.V. Van Kerrebroeck ◽  
F.M.J. Debruyne
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Nerve Root ◽  
Sacral Nerve Root ◽  
Sacral Nerve ◽  
Cord Injury ◽  
Root Stimulation

scholarly journals The Influence of Anterior Root Stimulation (S2) in Deafferented Spinal Cord Injury Men on Cavernous Electrical Activity

1992 ◽  
Vol 148 (1) ◽  
pp. 107-110 ◽  
Author(s):  
Christian G. Stief ◽  
Dieter Sauerwein ◽  
Walter F. Thon ◽  
Ernst P. Allhoff ◽  
Udo Jonas
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Electrical Activity ◽  
Cord Injury ◽  
Anterior Root ◽  
Root Stimulation

scholarly journals Electrical Stimulation Of The Cervical Dorsal Roots Enables Functional Arm And Hand Movements In Monkeys With Cervical Spinal Cord Injury

2020 ◽  
Author(s):  
B. Barra ◽  
S. Conti ◽  
M.G. Perich ◽  
K. Zhuang ◽  
G. Schiavone ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Electrical Stimulation ◽  
Motor Control ◽  
Cervical Spinal Cord ◽  
Three Dimensional ◽  
Arm Movements ◽  
Cervical Spinal Cord Injury ◽  
Cord Injury ◽  
Stimulation Of

SUMMARYRegaining arm motor control is a high priority for people with cervical spinal cord injury1. Unfortunately, no therapy can reverse upper limb paralysis. Promising neurotechnologies stimulating muscles to bypass the injury enabled grasping in humans with SCI2,3 but failed to sustain whole arm functional movements that are necessary for daily living activities. Here, we show that electrical stimulation of the cervical spinal cord enabled three monkeys with cervical SCI to execute functional, three-dimensional, arm movements. We designed a lateralized epidural interface that targeted motoneurons through the recruitment of sensory afferents within the dorsal roots and was adapted to the specific anatomy of each monkey. Simple stimulation bursts engaging single roots produced selective joint movements. We then triggered these bursts using movement-related intracortical signals, which enabled monkeys with arm motor deficits to perform an unconstrained, three-dimensional reach and grasp task. Our technology increased muscle activity, forces, task performance and quality of arm movements. Finally, analysis of intra-cortical neural data showed that a synergistic interaction between spared descending pathways and electrical stimulation enabled this restoration of voluntary motor control. Spinal cord stimulation is a mature clinical technology4–7, which suggests a realistic path for our approach to clinical applications.

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