Blood pressure lowering in elderly subjects: a double-blind crossover study of ω-3 and ω-6 fatty acids

1991 ◽  
Vol 53 (2) ◽  
pp. 562-572 ◽  
Author(s):  
G Margolin ◽  
G Huster ◽  
C J Glueck ◽  
J Speirs ◽  
J Vandegrift ◽  
...  
1983 ◽  
Vol 50 (02) ◽  
pp. 543-546 ◽  
Author(s):  
J Z Mortensen ◽  
E B Schmidt ◽  
A H Nielsen ◽  
J Dyerberg

SummaryDiverging results from studies of marine oil supplementation to western diets initiated the undertaking of a double-blind crossover study, with administration to healthy volunteers for 4 weeks of either 10 g of fish oil or 10 g of vegetable oil. Each oil containing approx. 40% of n-3 and n-6 polyunsaturated fatty acids (PUFA) respectively. During the n-3 PUFA period, systolic blood pressure, plasma total lipids, triglycerides and VLDL concentrations fell significantly whereas plasma antithrombin-III (AT-III) rose. Cutaneous bleeding time increased significantly. In contrast only AT-III rose during the n-6 PUFA feeding, however, more marked than during the n-3 oil period. It is concluded that a n-3 PUFA oil supplement to the western diet exerts an effect that generally is considered as beneficial in terms of the risk of developing cardiovascular diseases. It is in this respect superior to that of n-6 PUFA, stressing the necessity of a more differentiated approach to advices on dietary PUFA enrichment than presently is exerted.


PLoS ONE ◽  
2011 ◽  
Vol 6 (12) ◽  
pp. e28214 ◽  
Author(s):  
Isabelle Bauer ◽  
David P. Crewther ◽  
Andrew Pipingas ◽  
Renee Rowsell ◽  
Robyn Cockerell ◽  
...  

1979 ◽  
Vol 42 (02) ◽  
pp. 621-625 ◽  
Author(s):  
G G Nenci ◽  
G Agnelli ◽  
M Berrettini ◽  
P Parise ◽  
E Ballatori

SummaryIn a randomized double-blind crossover study in 16 patients with enhanced in vitro spontaneous platelet aggregation, sulfinpyrazone proved to be effective in normalizing platelet aggregability within 4 days after initiation of therapy.


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