scholarly journals Reduced rates of metabolism and decreased physical activity in breast cancer patients receiving adjuvant chemotherapy

1997 ◽  
Vol 65 (5) ◽  
pp. 1495-1501 ◽  
Author(s):  
W Demark-Wahnefried ◽  
V Hars ◽  
M R Conaway ◽  
K Havlin ◽  
B K Rimer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Adjuvant Chemotherapy ◽  
Cancer Patients ◽  
Breast Cancer Patients

Changes in Weight, Body Composition, and Factors Influencing Energy Balance Among Premenopausal Breast Cancer Patients Receiving Adjuvant Chemotherapy

2001 ◽  
Vol 19 (9) ◽  
pp. 2381-2389 ◽  
Author(s):  
Wendy Demark-Wahnefried ◽  
Bercedis L. Peterson ◽  
Eric P. Winer ◽  
Lawrence Marks ◽  
Noreen Aziz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Body Composition ◽  
Weight Gain ◽  
Energy Balance ◽  
Adjuvant Chemotherapy ◽  
Cancer Patients ◽  
Body Mass ◽  
Breast Cancer Patients ◽  
Lean Tissue

PURPOSE: Weight gain is a common problem among breast cancer patients who receive adjuvant chemotherapy (CT). We undertook a study to determine the causes of this energy imbalance. PATIENTS AND METHODS: Factors related to energy balance were assessed at baseline (within 3 weeks of diagnosis) and throughout 1 year postdiagnosis among 53 premenopausal women with operable breast carcinoma. Thirty-six patients received CT and 17 received only localized treatment (LT). Measures included body composition (dual energy x-ray absorptiometry), resting energy expenditure (REE; indirect calorimetry), dietary intake (2-day dietary recalls and food frequency questionnaires) and physical activity (physical activity records). RESULTS: Mean weight gain in the LT patients was 1.0 kg versus 2.1 kg in the CT group (P = .02). No significant differences between groups in trend over time were observed for REE and energy intake; however, a significant difference was noted for physical activity (P = .01). Several differences between groups in 1-year change scores were detected. The mean change (± SE) in LT versus CT groups and P values for uncontrolled/controlled (age, race, radiation therapy, baseline body mass index, and end point under consideration) analysis are as follows: percentage of body fat (−0.1 ± 0.4 v +2.2 ± 0.6%; P = .001/0.04); fat mass (+0.1 ± 0.3 v +2.3 ± 0.7 kg; P = .002/0.04); lean body mass (+0.8 ± 0.2 v −0.4 ± 0.3 kg; P = .02/0.30); and leg lean mass (+0.5 ± 0.1 v −0.2 ± 0.1 kg; P = .01/0.11). CONCLUSION: These data do not support overeating as a cause of weight gain among breast cancer patients who receive CT. The data suggest, however, that CT-induced weight gain is distinctive and indicative of sarcopenic obesity (weight gain in the presence of lean tissue loss or absence of lean tissue gain). The development of sarcopenic obesity with evidence of reduced physical activity supports the need for interventions focused on exercise, especially resistance training in the lower body, to prevent weight gain.

scholarly journals Effects of Scheduled Exercise on Cancer-Related Fatigue in Women with Early Breast Cancer

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Anne Marie Lunde Husebø ◽  
Sindre Mikal Dyrstad ◽  
Ingvil Mjaaland ◽  
Jon Arne Søreide ◽  
Edvin Bru
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Adjuvant Chemotherapy ◽  
Cancer Patients ◽  
Exercise Intervention ◽  
Activity Level ◽  
Control Group ◽  
Activity Levels ◽  
Breast Cancer Patients ◽  
Cancer Related Fatigue

While physical activity during cancer treatment is found beneficial for breast cancer patients, evidence indicates ambiguous findings concerning effects of scheduled exercise programs on treatment-related symptoms. This study investigated effects of a scheduled home-based exercise intervention in breast cancer patients during adjuvant chemotherapy, on cancer-related fatigue, physical fitness, and activity level. Sixty-seven women were randomized to an exercise intervention group (n=33, performed strength training 3x/week and 30 minutes brisk walking/day) and a control group (n=34, performed their regular physical activity level). Data collection was performed at baseline, at completion of chemotherapy (Post1), and 6-month postchemotherapy (Post2). Exercise levels were slightly higher in the scheduled exercise group than in the control group. In both groups, cancer-related fatigue increased at Post1but returned to baseline at Post2. Physical fitness and activity levels decreased at Post1but were significantly improved at Post2. Significant differences between intervention and control groups were not found. The findings suggest that generally recommended physical activity levels are enough to relief cancer-related fatigue and restore physical capacity in breast cancer patients during adjuvant chemotherapy, although one cannot rule out that results reflect diminishing treatment side effects over time.

Reduced rates of metabolism and decreased physical activity in breast cancer patients receiving adjuvant chemotherapy.

1997 ◽  
Vol 15 (3) ◽  
pp. 21
Author(s):  
W Demark-Wahnefried ◽  
V Hars ◽  
MR Conaway ◽  
K Havlin ◽  
BK Rimer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Adjuvant Chemotherapy ◽  
Cancer Patients ◽  
Breast Cancer Patients
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