scholarly journals Genetic, lifestyle, and health-related characteristics of adults without celiac disease who follow a gluten-free diet: a population-based study of 124,447 participants

2020 ◽  
Author(s):  
Thomas J Littlejohns ◽  
Amanda Y Chong ◽  
Naomi E Allen ◽  
Matthew Arnold ◽  
Kathryn E Bradbury ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Genome Wide Association Study ◽  
Population Based ◽  
Gluten Free Diet ◽  
Hospital Inpatient ◽  
Gluten Free ◽  
A Genome ◽  
Wide Range ◽  
Health Related ◽  
Reported Health

ABSTRACT Background The number of gluten-free diet followers without celiac disease (CD) is increasing. However, little is known about the characteristics of these individuals. Objectives We address this issue by investigating a wide range of genetic and phenotypic characteristics in association with following a gluten-free diet. Methods The cross-sectional association between lifestyle and health-related characteristics and following a gluten-free diet was investigated in 124,447 women and men aged 40–69 y from the population-based UK Biobank study. A genome-wide association study (GWAS) of following a gluten-free diet was performed. Results A total of 1776 (1.4%) participants reported following a gluten-free diet. Gluten-free diet followers were more likely to be women, nonwhite, highly educated, living in more socioeconomically deprived areas, former smokers, have lost weight in the past year, have poorer self-reported health, and have made dietary changes as a result of illness. Conversely, these individuals were less likely to consume alcohol daily, be overweight or obese, have hypertension, or use cholesterol-lowering medication. Participants with hospital inpatient diagnosed blood and immune mechanism disorders (OR: 1.62; 95% CI: 1.18, 2.21) and non-CD digestive system diseases (OR: 1.58; 95% CI: 1.42, 1.77) were more likely to follow a gluten-free diet. The GWAS demonstrated that no genetic variants were associated with being a gluten-free diet follower. Conclusions Gluten-free diet followers have a better cardiovascular risk profile than non-gluten-free diet followers but poorer self-reported health and a higher prevalence of blood and immune disorders and digestive conditions. Reasons for following a gluten-free diet warrant further investigation.

scholarly journals NUTRITIONAL STATUS AND HEALTH-RELATED QUALITY OF LIFE IN ADULT PATIENTS WITH CELIAC DISEASE

2018 ◽  
Vol 6 ◽  
pp. 952-959
Author(s):  
Yeliz Serin ◽  
Gamze Akbulut
Keyword(s):  
Quality Of Life ◽  
Celiac Disease ◽  
Nutritional Status ◽  
Gluten Free Diet ◽  
Survey Method ◽  
Gluten Free ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

Objective: This study evaluated the effect of nutrition on health-related quality of life in adult celiac patients.Material-Methods: A total of 103 individuals (26 males and 77 females) diagnosed with celiac disease by a physician, registered in the Ankara Celiac Society, and between 20 and 50 years old were enrolled in the study. Research data was collected using the face-to-face survey method with the “Celiac Disease in Health-Related Quality of Life Survey” to evaluate participants’ quality of life. Patient nutrient intake was determined using the 24-hour dietary recall method.Results: The mean age of the patients was 37.5±8.89 years and the age at diagnosis was 31.0±11.85 years. The body mass index value was 22.7±3.57 kg/m2. When the nutritional status of the participants was evaluated, the energy received from carbohydrates and protein was less, whereas the energy received from fat was more than the general recommendations. When the total quality of life score was evaluated, the average scores of men were higher than women (146.6±17.51 vs. 123.7±24.78). In addition, the total and subscale quality of life scores varied by gender, comorbid conditions, compliance with a gluten-free diet, and the duration of the gluten-free diet.Conclusions: Celiac is a disease that requires a lifelong gluten-free diet. Most celiac patients have nutritional deficiencies and poor quality of life standards. In order to prevent these deficiencies, commercially prepared foods should be enriched, especially in vitamins and minerals. In addition, increasing awareness of celiac disease in society positively affects the quality of life of individuals.

655 Health-Related Quality of Life in Adolescents With Screening-Detected Celiac Disease: Assessments Before Diagnosis and After One Year With Gluten-Free Diet

2014 ◽  
Vol 146 (5) ◽  
pp. S-114
Author(s):  
Anna Myléus ◽  
Solveig Petersen ◽  
Anneli Carlsson ◽  
Solveig Hammarroth ◽  
Lotta Högberg ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Celiac Disease ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
One Year

Clinical Benefit of a Gluten-Free Diet in Type 1 Diabetic Children With Screening-Detected Celiac Disease: A population-based screening study with 2 years' follow-up

Diabetes Care ◽  
2006 ◽  
Vol 29 (11) ◽  
pp. 2452-2456 ◽  
Author(s):  
D. Hansen ◽  
B. Brock-Jacobsen ◽  
E. Lund ◽  
C. Bjorn ◽  
L. P. Hansen ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Clinical Benefit ◽  
Population Based ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Diabetic Children ◽  
Screening Study

scholarly journals Health-Related Quality of Life in Children and Adolescents with Celiac Disease: From the Perspectives of Children and Parents

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Ing-Marie Byström ◽  
Elisabet Hollén ◽  
Karin Fälth-Magnusson ◽  
AnnaKarin Johansson
Keyword(s):  
Quality Of Life ◽  
Celiac Disease ◽  
Children And Adolescents ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Health Related Quality ◽  
Children And Parents ◽  
Related Quality ◽  
Health Related

Aim. To examine how celiac children and adolescents on gluten-free diet valued their health-related quality of life, and if age and severity of the disease at onset affected the children’s self-valuation later in life. We also assessed the parents’ valuation of their child’s quality of life.Methods. The DISABKIDS Chronic generic measure, short versions for both children and parents, was used on 160 families with celiac disease. A paediatric gastroenterologist classified manifestations of the disease at onset retrospectively.Results. Age or sex did not influence the outcome. Children diagnosed before the age of five scored higher than children diagnosed later. Children diagnosed more than eight years ago scored higher than more recently diagnosed children, and children who had the classical symptoms of the disease at onset scored higher than those who had atypical symptoms or were asymptomatic. The parents valuated their children’s quality of life as lower than the children did.Conclusion. Health-related quality of life in treated celiac children and adolescents was influenced by age at diagnosis, disease severity at onset, and years on gluten-free diet. The disagreement between child-parent valuations highlights the importance of letting the children themselves be heard about their perceived quality of life.

A Clinical and Histochemical Study of Celiac Disease Before and During a Gluten-Free Diet

1965 ◽  
Vol 48 (2) ◽  
pp. 155-172 ◽  
Author(s):  
I. Michael Samloff ◽  
John S. Davis ◽  
Eric A. Schenk
Keyword(s):  
Celiac Disease ◽  
Histochemical Study ◽  
Gluten Free Diet ◽  
Gluten Free
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