Variations in the Free HCl Content of Gastric Juice in 61 Normal Subjects*

1940 ◽  
Vol 10 (ts4_5) ◽  
pp. 108-113 ◽  
Author(s):  
Eleanor W. Townsend
Keyword(s):  
Gastric Juice ◽  
Normal Subjects

Somatostatin in gastric juice in normal subjects and patients with duodenal ulcer

1992 ◽  
Vol 37 (7) ◽  
pp. 1020-1024 ◽  
Author(s):  
Koji Sumii ◽  
Masaaki Sumioka ◽  
Masaharu Yoshihara ◽  
Akira Tari ◽  
Ken Haruma ◽  
...  
Keyword(s):  
Duodenal Ulcer ◽  
Gastric Juice ◽  
Normal Subjects

Comparison of Mucus Substances in Gastric Juice of Normal Subjects, Duodenal Ulcer and Dyspeptic Patients

1983 ◽  
Vol 15 (1) ◽  
pp. 11-17 ◽  
Author(s):  
Joan D. Donaldson ◽  
K.D. MacRae ◽  
T.G. Parks
Keyword(s):  
Duodenal Ulcer ◽  
Gastric Juice ◽  
Normal Subjects

scholarly journals The pepsins of normal human gastric juice

1969 ◽  
Vol 113 (4) ◽  
pp. 663-668 ◽  
Author(s):  
D J Etherington ◽  
W H Taylor
Keyword(s):  
Gastric Juice ◽  
Proteolytic Activity ◽  
Gel Electrophoresis ◽  
Normal Subjects ◽  
Frequency Of Occurrence ◽  
Agar Gel ◽  
Human Gastric Juice ◽  
Normal Human ◽  
Agar Gel Electrophoresis ◽  
A Minor

1. The frequency of occurrence, under defined conditions, of the different human pepsins in the gastric juices of 50 normal subjects was investigated by agar-gel electrophoresis. 2. From a total of eight proteolytic zones located in the zymograms, no significant differences of occurrence existed between the sexes, or between subjects with or without gastric symptoms. 3. Two zones, numbered 3 and 5, occurred in all normal gastric juices. Zone 3 always exhibited the greatest proteolytic activity, then zone 5. The remaining enzymic zones were less well-marked and occurred less frequently. 4. A minor zone, 3a, was demonstrated within zone 3. The corresponding pepsin, 3a, has a mobility towards the anode 6–7% greater than has pepsin 3. 5. Of the eight zones, 1,2,3,3a and 5, at least, represent unique pepsins.

scholarly journals The pepsins from human gastric mucosal extracts

1970 ◽  
Vol 118 (4) ◽  
pp. 587-594 ◽  
Author(s):  
D. J. Etherington ◽  
W. H. Taylor
Keyword(s):  
Gastric Juice ◽  
Gel Electrophoresis ◽  
Normal Subjects ◽  
Exchange Chromatography ◽  
Agar Gel ◽  
Inhibitor Complex ◽  
Normal Human ◽  
Agar Gel Electrophoresis ◽  
The Individual ◽  
Pepsin Inhibitor

1. The pepsins and pepsinogens of the gastric mucosal extracts of two normal subjects, of seven patients with gastric adenocarcinoma and of two patients with duodenal ulcer have been investigated by agar-gel electrophoresis and by ion-exchange chromatography. 2. Of the eight zones of proteolytic activity that have previously been reported in normal human gastric juice, seven can be detected in activated fundic mucosal extracts. Of these seven, four can be attributed to discrete pepsins, numbered 1, 3a, 3 and 5. 3. Zone 7 results from the activity of one or more enzymes that are alkali-stable and are best referred to as gastric proteinases rather than as pepsins. Zone 7 is much more evident in mucosal extracts than in gastric juice. 4. Zones 4 and 6 may result respectively from the activity of a pepsin–inhibitor complex and of an unactivated zymogen. 5. It was not possible, by the chromatographic methods employed, to separate satisfactorily the individual pepsins from activated extracts or their precursors from unactivated extracts, so that the ascribing of a pepsin to a specific zymogen must be considered tentative. Even so, pepsin 3 appears to arise from at least two major precursors, if not from three, whereas pepsins 1 and 5 each arise from a single major precursor. 6. Pyloric mucosal extracts contain principally zone 5 but also zones 6 and 7. These zones in general behave similarly to the corresponding zones of fundic extracts, but pyloric pepsin 5 migrates slightly faster on agar-gel electrophoresis than does fundic pepsin 5 and is a different enzyme. Zones 1 to 4 are absent.

Studies on the Nature of Complexes Formed by Copper with Human Alimentary Secretions and Their Influence on Copper Absorption in the Rat

1975 ◽  
Vol 49 (3) ◽  
pp. 237-245 ◽  
Author(s):  
J. L. Gollan
Keyword(s):  
Molecular Weight ◽  
Gall Bladder ◽  
Gastric Juice ◽  
Copper Complexes ◽  
Normal Subjects ◽  
Low Molecular Weight ◽  
Gel Chromatography ◽  
Copper Binding ◽  
Control Series

1. Human gastrointestinal secretions formed soluble copper complexes when labelled in vitro with 64Cu. 2. Copper-binding substances of low molecular weight were demonstrated in the saliva, gastric juice and secretin-stimulated duodenal aspirate of normal subjects by dialysis and gel-chromatography studies. 3. The nature of the copper complexes formed by secretions obtained from patients with Wilson's disease was similar to that of complexes formed by secretions of normal subjects. 4. Bile contained a copper-binding fraction of high molecular weight which was more concentrated in gall-bladder than hepatic bile. Between pH 5 and pH 8, this component had a greater binding affinity for copper than the other alimentary secretions or EDTA at a concentration of 10 mmol/l. 5. Absorption of 64Cu from 64Cu-labelled saliva, gastric juice or l-histidine solution (100 mmol/l) administered intraduodenally into groups of rats was similar to that observed in a control series given [64Cu]cupric acetate in sodium chloride solution. In contrast, the absorption of 64Cu from labelled hepatic and gall-bladder bile was significantly reduced. 6. The results suggest that dietary copper forms soluble complexes with the alimentary secretions and that these complexes influence absorption of the metal according to their molecular size. The net uptake of ingested copper from the gut lumen may represent a balance between the influence of dietary chelates, low-molecular-weight ligands in the alimentary secretions and a macromolecular copper-binding complex of bile.

Auditory Selective Attention in Cerebral-Palsied Individuals

1985 ◽  
Vol 16 (4) ◽  
pp. 260-266 ◽  
Author(s):  
Lee Ann Laraway
Keyword(s):  
Selective Attention ◽  
White Noise ◽  
Normal Subjects ◽  
Auditory Selective Attention ◽  
Normal Individuals ◽  
Significant Difference

The purpose of this study was to determine whether there is a statistically significant difference between the auditory selective attention abilities of normal and cerebral-palsied individuals. Twenty-three cerebral-palsied and 23 normal subjects between the ages of 5 and 21 were asked to repeat a series of 30 items consisting of from 2 to 4 digits in the presence of intermittent white noise. Results of the study indicate that cerebral-palsied individuals perform significantly poorer than normal individuals when the stimulus is accompanied by noise. Noise was not a significant factor in the performance of the normal subjects regardless of age.

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