scholarly journals 253 Ovarian Sertoli-Leydig Cell Tumor Presenting With Nonspecific Symptoms, in an Elderly Patient With Family History of Gastrointestinal Stromal Tumor

2018 ◽  
Vol 149 (suppl_1) ◽  
pp. S107-S108
Author(s):  
Monira Haque ◽  
Nadia Hameed ◽  
Wadad Mneimneh
Keyword(s):  
Elderly Patient ◽  
Family History ◽  
Gastrointestinal Stromal Tumor ◽  
Leydig Cell ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Stromal Tumor ◽  
History Of

scholarly journals Poorly Differentiated Ovarian Sertoli-Leydig Cell Tumor in a 16-Year-Old Single Woman: A Case Report and Literature Review

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Ahmed Abu-Zaid ◽  
Ayman Azzam ◽  
Lama Abdulhamid Alghuneim ◽  
Mona Tarek Metawee ◽  
Tarek Amin ◽  
...  
Keyword(s):  
Literature Review ◽  
Leydig Cell ◽  
Ovarian Neoplasms ◽  
Case Reports ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Single Woman ◽  
History Of ◽  
Poorly Differentiated ◽  
Sex Cord Stromal Tumors

Sertoli-Leydig cell tumor (SLCT) of ovary is an exceedingly unusual neoplasm that belongs to a group of sex cord-stromal tumors of ovary and accounts for less than 0.5% of all primary ovarian neoplasms. Very few case reports have been documented in the literature so far. Herein, we report a case of primary poorly differentiated ovarian Sertoli-Leydig cell tumor (SLCT) involving the left ovary in a 16-year-old single woman who presented with a 3-month history of a pelviabdominal mass, acne, hirsutism, and menstrual irregularities. In addition, a literature review on ovarian SLCTs is provided.

Leydig cell tumor in an elderly patient with complete androgen insensitivity syndrome

2005 ◽  
Vol 96 (3) ◽  
pp. 870-872 ◽  
Author(s):  
Ichiro Iwamoto ◽  
Shintaro Yanazume ◽  
Toshinori Fujino ◽  
Takako Yoshioka ◽  
Tsutomu Douchi
Keyword(s):  
Elderly Patient ◽  
Leydig Cell ◽  
Androgen Insensitivity Syndrome ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Complete Androgen Insensitivity Syndrome ◽  
Androgen Insensitivity

The Unique Simultaneous Occurrence of Granular Cell Tumor, Gastrointestinal Stromal Tumor, and Gastric Adenocarcinoma

2005 ◽  
Vol 129 (5) ◽  
pp. e121-e123
Author(s):  
Joseph L. Sailors ◽  
Samuel W. French
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Gastric Adenocarcinoma ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor ◽  
Stromal Tumor ◽  
Simultaneous Occurrence ◽  
First Case ◽  
History Of ◽  
Schwannian Origin

Abstract Granular cell tumors are generally benign oncocytoid lesions of schwannian origin that are often incidental findings in many locations. Gastrointestinal stromal tumors occur in older adults and express the c-Kit protein (CD117). Both of these tumors have been described in association with many other entities; however, they have never been reported to occur jointly. This report is prompted by the simultaneous appearance of 2 granular cell tumors, a gastrointestinal stromal tumor, and a gastric adenocarcinoma in a 65-year-old woman with a history of breast carcinoma and granular cell tumor. To our knowledge, this is the first case report of these tumors occurring simultaneously.

scholarly journals DICER1 -related Sertoli-Leydig cell tumor and gynandroblastoma: Clinical and genetic findings from the International Ovarian and Testicular Stromal Tumor Registry

2017 ◽  
Vol 147 (3) ◽  
pp. 521-527 ◽  
Author(s):  
Kris Ann P. Schultz ◽  
Anne K. Harris ◽  
Michael Finch ◽  
Louis P. Dehner ◽  
Jubilee B. Brown ◽  
...  
Keyword(s):  
Leydig Cell ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Stromal Tumor ◽  
Tumor Registry

scholarly journals Tumor de Células de Leydig num Doente com Criptorquidia Contralateral: Uma Associação Rara

2020 ◽  
Vol 33 (13) ◽  
Author(s):  
Ricardo Capitão ◽  
Catarina Saraiva ◽  
Clara Cunha ◽  
Mónica Martins
Keyword(s):  
Leydig Cell ◽  
Previous History ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Timely Manner ◽  
Testicular Tumors ◽  
History Of ◽  
The Right ◽  
Subsequent Improvement ◽  
Leydig Cell Tumors

Gynecomastia is a frequent sign that may be physiological or caused by various benign or malignant diseases. In rare cases, it may be caused by testicular tumors. We describe a case of progressive gynecomastia at age 20 due to a Leydig cell tumor of the right testicle in a patient with a previous history of left-sided cryptorchidism. The patient underwent orchidectomy and testicular prosthesis placement, with subsequent improvement of gynecomastia and normalization of estrogen. Our case, in addition to demonstrating that gynecomastia may regress if the underlying cause is treated in a timely manner, shows that cryptorchidism may be related with the development of Leydig cell tumors in the same way as it is in other testicular tumors.

scholarly journals SUN-011 Beyond PCOS - Ovarian Neoplasms Presenting with Hirsutism and Virilization

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Shourjo Chakravorty ◽  
Brandon Hoard ◽  
Gina Cosentino ◽  
Karen E Friday ◽  
Gabriel Ikponmosa Uwaifo
Keyword(s):  
Leydig Cell ◽  
Ovarian Neoplasms ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Total Serum ◽  
Symptom Improvement ◽  
Ovarian Mass ◽  
Multiple Imaging ◽  
History Of ◽  
Androgen Levels

Abstract BACKGROUND: PCOS is the most common cause of hirsutism in women of reproductive age. The presence of virilization in addition to hirsutism should alert to the possibility of less common causes of hyper-androgenization (HA) in this population including otherwise uncommon functional ovarian neoplasms (FON). We present 3 cases of women initially thought to have PCOS in whom virilization was the prime clue to the correct diagnosis of FON. Clinical Case series: Case 1 is a 40yr old woman with obesity and dysmetabolic syndrome referred for hirsutism presumed due to PCOS. She had noted symptoms over 2–3 yrs with amenorrhea and associated infertility. Examination revealed marked hirsutism and virilization with Ferriman-Galleway score (FGS) of 20. Lab tests confirmed marked male range HA. Multiple imaging tests revealed no adrenal or ovarian mass lesions. FDG-PET scan finally revealed a left ovarian focus for which she has left oophorectomy that revealed a 1cm Leydig cell tumor, Her HA resolved post-op and spontaneous periods resumed. Case 2 is a 45yr old woman referred with possible PCOS who had 5 mth history of progressive hirsutism and generalized hypertrichosis, dull lower abdominal pain and amenorrhea. Examination revealed marked hirsutism with generalized hypertrichosis and virilization. FGS was 25 and clitoral index was 935mm2. Lab tests confirmed marked male range HA and abdominopelvic imaging show no adrenal lesions but a 5.2cm left ovarian mass. Left salpingo-oophorectomy revealed a steroid cell tumor and postoperatively her androgen levels normalized. Case 3 is 37 yr old woman with SLE and obesity with prior gastric bypass referred with presumed PCOS but presenting with 1 yr history of progressive hirsutism. She was initially thought to have non classical CAH and treated with oral glucocorticoids with no symptom improvement. Examination revealed marked hirsutism, virilization with elevated FGS and clitoromegaly. Lab tests showed marked male range HA but multiple imaging studies revealed no apparent adrenal or ovarian lesions. Patient had no fertility interests and so had elective total hysterectomy and bilateral salpingo-oophorectomy. Histopathology revealed a 2.5cm left ovarian Leydig cell tumor not apparent at surgery and post op her androgen levels normalized. Conclusion: The distinction between PCOS which is ubiquitous and FON which is rare hinges on careful history and examination. Rapid onset hirsutism with virilization should prompt suspicion of FON. Marked male range HA (total serum testosterone >250ng/dl) is another “red flag” finding. Persistent radiologic search for such lesions should continue as they may not be immediately apparent on routine abdominopelvic imaging.

scholarly journals Sertoli-Leydig Cell Tumor (SLCT) of the Ovary - A Case Report

2020 ◽  
Vol 32 (2) ◽  
pp. 117-120
Author(s):  
Mst Moonmoon Begum ◽  
Ferdousi Sultana
Keyword(s):  
Leydig Cell ◽  
Ovarian Tumor ◽  
Early Stage ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Stromal Tumor ◽  
Primary Amenorrhea ◽  
Suspected Case ◽  
Early Stage Disease ◽  
Sex Cord Stromal Tumor

Sertoli-Leydig Cell Tumor (SLCT) is an extremely rare and distinctive sex cord-stromal tumor. Ovarian sex cord-stromal tumors are infrequent tumors that differ from the more frequent epithelial neoplasm and have strong association with hormone-mediated syndromes, presentation in a wide age range, and the diagnosis is usually at early-stage disease with a good outcome. SLCT typically present with pelvic or abdominal pain and tenderness, mass, and or abnormal menstruation, and with hormonal activity reported predominantly after menarche. We report a case of 18-year-old unmarried female presented with severe pain and lump in the lower abdomen. She was a case of primary amenorrhea with normal secondary sex characters. She was a suspected case of twisted ovarian tumor on USG and underwent laparotomy followed by total excision of the lump and histopathology report revealed Sertoli-Leydig Cell Tumor. Though it is a rare tumor, the possibility of Sertoli-Leydig Cell Tumor in a young woman should be kept in mind. Key Words: Ovarian tumor, Sclerosing stromal tumor, sex cord-stromal tumor, Sertoli- Leydig Cell Tumor. Bangladesh J Obstet Gynaecol, 2017; Vol. 32(2) : 117-120

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