Background. It is urgent to find alternative agents due to increasing failure rate ofHelicobacter pylori (H. pylori) eradication. The study surveyed the long-term effect of silver nanoparticles (AgNP) onH. pyloribased on Mongolian gerbil’s model.Materials and Methods. Fifty gerbils were randomly allocated to six groups (A–F). Group (Gr) A: the gerbils were fed with broth; Gr B and D: the gerbils were fed with AgNP/clay complex (0.1% of weight); Gr C and E: the gerbils were fed with AgNP/clay complex(1% of weight); and Gr D, E, and F: the gerbils were inoculated withH. pylori. At the 20th experimental week, the gerbils were sacrificed. Histology was evaluated according to the classification of the Sydney system.P<0.05was considered to be statistically significant.Results. The AgNP/clay has more obvious inhibitory effect onH. pyloriin vitro. There was a trend of higher concentrations of AgNP with stronger inhibitory effect onH. pylorigrowth(P=0.071). There were no significant differences of inflammation among groups D, E, and F(P=0.688).Conclusion. AgNP/clay would be a potential and safe agent for inhibitingH. pylori. It should be helpful for eradication ofH. pyloriinfection.
Does Long-Term Use of Silver Nanoparticles Have Persistent Inhibitory Effect onH. pyloriBased on Mongolian Gerbil’s Model?
