scholarly journals Carotid Body Denervation Markedly Improves Survival in Rats With Hypertensive Heart Failure

2017 ◽  
Vol 30 (8) ◽  
pp. 791-798 ◽  
Author(s):  
Kana Fujii ◽  
Keita Saku ◽  
Takuya Kishi ◽  
Yasuhiro Oga ◽  
Takeshi Tohyama ◽  
...  
Keyword(s):  
Heart Failure ◽  
Carotid Body ◽  
Carotid Body Denervation

Abstract 17082: Carotid Body Denervation Improves Autonomic Balance and Prevents the Worsening of Heart Failure in Rats After Large Myocardial Infarction

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Keita Saku ◽  
Takuya Kishi ◽  
Akiko Nishizaki ◽  
Kana Fujii ◽  
Takuya Akashi ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Carotid Body ◽  
High Frequency ◽  
Diastolic Pressure ◽  
Plasma Norepinephrine ◽  
Autonomic Balance ◽  
Sprague Dawley ◽  
Lung Weight ◽  
Carotid Body Denervation

Introduction: Carotid body denervation (CBD) abolishes the carotid body hypersensitivity induced sympathoexcitatory hypertension. Since the carotid body hypersensitivity is a salient feature and predicts poor outcome of chronic heart failure (CHF), we hypothesized that CBD restores normal autonomic balance, thus improves CHF in rats after large myocardial infarction (MI). Methods: We created MI in 8 weeks Sprague-Dawley rats. Surviving rats at 2 weeks after MI were randomized into CBD (n=11) and sham-operated (Sham; n=13) groups. We removed the tissues around the carotid bifurcation and established CBD. In some rats (Sham; n=5, CBD; n=5), we telemetrically recorded heart rate (HR). One month after CBD, we compared physiological, histological and immunochemical findings between CBD and Sham. Results: CBD significantly reduced HR (337±15 vs. 364±12 bpm, p<0.05). CBD markedly increased the power spectral density of HR in the high frequency range (81.0±9.5 vs. 29.0±8.2 n.u., p<0.05) and decreased that of the low frequency/high frequency ratio (0.6±0.2 vs. 1.8±0.5, p<0.05) indicating the restoration of autonomic balance. CBD significantly reduced biventricular weight (3.1±0.3 vs. 3.7±0.3 g/kg, p<0.05) and left ventricle (LV) end-diastolic pressure (22±5 vs. 33±5 mmHg, p<0.01) and increased maximum LV dp/dt (5118±809 vs. 4217±472 mmHg/sec, p<0.05). CBD reduced lung weight (a marker of pulmonary edema) (6.8±2.0 vs. 12.4±1.5 g/kg, p<001). Furthermore, CBD reduced plasma brain natriuretic peptide (70±43 vs. 166±71 pg/ml, p<0.01) and plasma norepinephrine as an index of sympathetic drive (384±202 vs. 1048±997 pg/ml, p<0.05). CBD significantly reduced the number of inflammatory macrophages (345±45 vs. 474±73 counts/mm2, p<0.05) in the LV and the plasma concentration of interleukin-1β (14.3±4.7 vs. 24.5±11.8 pg/ml, p<0.05) indicating that CBD also suppressed the inflammatory response in CHF. Conclusions: CBD restores normal autonomic balance and prevents the worsening of heart failure in rats after large myocardial infarction. CBD may serve as a novel neuro-modulatory therapy for CHF patients.

scholarly journals Carotid body denervation improves autonomic and cardiac function and attenuates disordered breathing in congestive heart failure

2014 ◽  
Vol 592 (2) ◽  
pp. 391-408 ◽  
Author(s):  
Noah J. Marcus ◽  
Rodrigo Del Rio ◽  
Evan P. Schultz ◽  
Xiao-Hong Xia ◽  
Harold D. Schultz
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Cardiac Function ◽  
Carotid Body ◽  
Disordered Breathing ◽  
Carotid Body Denervation

Carotid Body Denervation Markedly Prevents the Worsening of Heart Failure in Rat after Large Myocardial Infarction

2014 ◽  
Vol 20 (10) ◽  
pp. S182
Author(s):  
Keita Saku ◽  
Takuya Kishi ◽  
Akiko Nishizaki ◽  
Kana Fujii ◽  
Takuya Akashi ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Carotid Body ◽  
Carotid Body Denervation

scholarly journals Is carotid body denervation the silver bullet for heart failure?

2014 ◽  
Vol 592 (6) ◽  
pp. 1179-1180
Author(s):  
Blair D. Johnson ◽  
Jacqueline K. Limberg
Keyword(s):  
Heart Failure ◽  
Carotid Body ◽  
Silver Bullet ◽  
Carotid Body Denervation

Carotid Body Denervation Improves Survival with Sympatho-inhibition in Rats with Hypertensive Heart Failure

2015 ◽  
Vol 21 (10) ◽  
pp. S197
Author(s):  
Kana Fujii ◽  
Keita Saku ◽  
Yasuhiro Oga ◽  
Akiko Nishizaki ◽  
Takako Takehara ◽  
...  
Keyword(s):  
Heart Failure ◽  
Carotid Body ◽  
Carotid Body Denervation

Plasticity of cardiovascular chemoreflexes after prolonged unilateral carotid body denervation: implications for its therapeutic use

2020 ◽  
Vol 318 (5) ◽  
pp. H1325-H1336
Author(s):  
Jaime Eugenín ◽  
Carolina Larraín ◽  
Patricio Zapata
Keyword(s):  
Carotid Body ◽  
Therapeutic Use ◽  
Therapeutic Effectiveness ◽  
Sympathetic Outflow ◽  
Sympathetic Hyperactivity ◽  
Functional Changes ◽  
Human Disorders ◽  
Carotid Body Denervation

Unilateral carotid body denervation has been proposed as treatment for sympathetic hyperactivity-related human disorders. Its therapeutic effectiveness for maintaining a persistent decrease in the sympathetic outflow activity will depend on the absence of compensatory chemoreflex plasticity in the remnant carotid and aortic afferents. Here, we suggest that the integrity of central afferents after carotid body denervation is essential to prevent the emergence of plastic functional changes on the contralateral “intact” carotid nerve.

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