scholarly journals The International Prognostic Index predicts outcome in aggressive adult T-cell leukemia/lymphoma: analysis of 126 patients from the International Peripheral T-cell Lymphoma Project

2009 ◽  
Vol 20 (4) ◽  
pp. 715-721 ◽  
Author(s):  
J. Suzumiya ◽  
K. Ohshima ◽  
K. Tamura ◽  
K. Karube ◽  
N. Uike ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
International Prognostic Index ◽  
Prognostic Index ◽  
T Cell Lymphoma ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Peripheral T Cell Lymphoma ◽  
Adult T Cell Leukemia

scholarly journals Molecular signatures to improve diagnosis in peripheral T-cell lymphoma and prognostication in angioimmunoblastic T-cell lymphoma

Blood ◽  
2010 ◽  
Vol 115 (5) ◽  
pp. 1026-1036 ◽  
Author(s):  
Javeed Iqbal ◽  
Dennis D. Weisenburger ◽  
Timothy C. Greiner ◽  
Julie M. Vose ◽  
Timothy McKeithan ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
High Expression ◽  
Molecular Signature ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Peripheral T Cell Lymphoma ◽  
Angioimmunoblastic T Cell Lymphoma ◽  
Adult T Cell Leukemia

Abstract Peripheral T-cell lymphoma (PTCL) is often challenging to diagnose and classify. Gene expression profiling was performed on 144 cases of PTCL and natural killer cell lymphoma and robust molecular classifiers were constructed for angioimmunoblastic T-cell lymphoma (AITL), anaplastic lymphoma kinase-positive (ALK+) anaplastic large-cell lymphoma (ALCL), and adult T-cell leukemia/lymphoma. PTCL-unclassifiable was molecularly heterogeneous, but we were able to identify a molecular subgroup with features of cytotoxic T lymphocytes and a poor survival compared with the remaining PTCL–not otherwise specified cases. Many of the pathologic features and substantial components of the molecular signature of AITL are contributed by the follicular dendritic cells, B-cell, and other stromal components. The expression of Th17-associated molecules in ALK+ ALCL was noted and may represent aberrant activation of Th17-cell differentiation by abnormal cytokine secretion. Adult T-cell leukemia/lymphoma has a homogeneous molecular signature demonstrating high expression of human T-lymphotropic virus type 1–induced genes. These classifiers reflect the biology of the tumor cells as well as their microenvironment. We also constructed a molecular prognosticator for AITL that appears to be largely related to the microenvironmental signature, and the high expression of 2 immunosuppressive signatures are associated with poor outcome. Oncogenic pathways and tumor-host interactions also were identified, and these findings may lead to better therapies and outcome in the future.

THP-COP regimen for the treatment of peripheral T-cell lymphoma and adult T-cell leukemia/lymphoma: a multicenter phase II study

2010 ◽  
Vol 84 (5) ◽  
pp. 391-397 ◽  
Author(s):  
Yasushi Takamatsu ◽  
Junji Suzumiya ◽  
Atae Utsunomiya ◽  
Koichi Maeda ◽  
Hitoshi Matsuoka ◽  
...  
Keyword(s):  
T Cell ◽  
Phase Ii ◽  
Phase Ii Study ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Peripheral T Cell Lymphoma ◽  
Adult T Cell Leukemia ◽  
Multicenter Phase

Detection of NOTCH1 Mutations in Adult T-Cell Leukemia/Lymphoma and Peripheral T-Cell Lymphoma

2007 ◽  
Vol 85 (3) ◽  
pp. 212-218 ◽  
Author(s):  
Daisuke Shimizu ◽  
Tomohiko Taki ◽  
Atae Utsunomiya ◽  
Hitoshi Nakagawa ◽  
Kenichi Nomura ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Peripheral T Cell Lymphoma ◽  
Adult T Cell Leukemia ◽  
Notch1 Mutations

Cutaneous T-cell lymphoma with HTLV-I infection: clinical overlap with adult T-cell leukemia/lymphoma

2006 ◽  
Vol 45 (4) ◽  
pp. 447-449 ◽  
Author(s):  
F. H. Sakamoto ◽  
G. W. B Colleoni ◽  
S. P. Teixeira ◽  
M. Yamamoto ◽  
N. S. Michalany ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia

scholarly journals Baseline and interim functional imaging with PET effectively risk stratifies patients with peripheral T-cell lymphoma

2019 ◽  
Vol 3 (2) ◽  
pp. 187-197 ◽  
Author(s):  
Neha Mehta-Shah ◽  
Kimiteru Ito ◽  
Kurt Bantilan ◽  
Alison J. Moskowitz ◽  
Craig Sauter ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
T Cell ◽  
Confidence Interval ◽  
Cell Lymphoma ◽  
Univariate Analysis ◽  
International Prognostic Index ◽  
Prognostic Index ◽  
Standardized Uptake Value ◽  
T Cell Lymphoma ◽  
Peripheral T Cell Lymphoma

Abstract The prognosis of peripheral T-cell lymphoma (PTCL) is heterogenous. Baseline or interim imaging characteristics may inform risk-adapted treatment paradigms. We identified 112 patients with PTCL who were consecutively treated with cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP)/CHOP-like regimens with the intent to consolidate with an autologous transplant. Baseline (n = 93) and interim (after 4 cycles, n = 99) positron emission tomography (PET) images were reevaluated, and we calculated baseline total metabolic tumor volume (TMTV). Interim PET (iPET) responses were graded visually by 5-point score (i5PS) and by percentage change of standardized uptake value. By univariate analysis, predictors of event-free survival (EFS) included Prognostic Index for Peripheral TCL (PIT) higher than 1 (hazard ratio [HR], 1.83; P = .021), International Prognostic Index (IPI) higher than 3 (HR, 2.01; P = .021), high TMTV (>125 cm3; HR, 3.92; P = .003), and positive iPET (HR, 3.57; P < .001). By multivariate analysis, high baseline TMTV predicted worse overall survival (OS; HR, 6.025; P = .022) and EFS (HR, 3.861; P = .005). Patients with i5PS of 1 to 3 had a longer median OS and EFS (104 months, 64 months) than those with i5PS of 4 to 5 (19 months, 11 months; P < .001). Four-year OS and EFS for patients with i5PS of 1 to 3 and PIT of 1 or less were 85% and 62%, respectively. However, 4-year OS and EFS for those with i5PS of 4 to 5 and PIT higher than 1 were both 0% (P < .001). In multivariate analysis, after controlling for IPI and PIT, i5PS was independently prognostic for EFS (HR, 3.400 95% confidence interval, 1.750-6.750; P < .001) and OS (HR, 10.243; 95% confidence interval, 4.052-25.891; P < .001). In conjunction with clinical parameters, iPET helps risk stratify patients with PTCL and could inform risk-adapted treatment strategies. Prospective studies are needed to confirm these findings.

Comparative study of cutaneous T-cell lymphoma and adult T-cell leukemia lymphoma

1991 ◽  
Vol 2 (3) ◽  
pp. 229
Author(s):  
Tetsuo Nagatani ◽  
Toshiko Matsuzaki ◽  
Naoko Baba ◽  
Hideaki Miyamoto ◽  
Hiroshi Nakajima
Keyword(s):  
T Cell ◽  
Comparative Study ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia
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