Prognostic significance of positive lymph node ratio in patients with pN3 gastric cancer who underwent curative gastrectomy

Abstract OBJECTIVE: To investigate prognostic significance of n1 and n2 station metastatic lymph node ratio(rN) after distal gastric cancer surgery. METHODS: A total of 408 patients who underwent radical distal gastrectomy (D2) under general anesthesia in 2012-2014. The critical value of rN1 and rN2 were calculated respectively. Prognostic factors were identified by univariate and multivariate analyses.RESULTS: An rN1 of 0.140 and rN2 of 0.100 was found to be the best cut-off value to determine the prognosis of patients with distal gastric cancer (p < 0.001).Univariate and multivariate analysis show that gender, age, nerves invaded, carcinoma nodules, LNS, LNS1, LNS2 were non-prognostic factors.tumor size, depth of invasion,blood vessels invaded,degree of differentiation,rN, PLNS1,rN1, PLNS2, rN2,pTNM were prognostic factors. Among prognostic factors, the partial regression coefficients were, from high to low, pTNM, rN2, rN2, rN. CONCLUSION: RN1 and RN2 is a better prognostic tool for gastric cancer patients after curative distal gastrectomy.which is a beneficial and reliable technique for evaluating lymph node metastasis.

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Re-evaluating the prognostic validity of the negative to positive lymph node ratio in node-positive gastric cancer patients

Surgery ◽

10.1016/j.surg.2016.12.018 ◽

2017 ◽

Vol 161 (6) ◽

pp. 1588-1596 ◽

Cited By ~ 9

Author(s):

Hiroharu Yamashita ◽

Jingyu Deng ◽

Han Liang ◽

Yasuyuki Seto

Keyword(s):

Gastric Cancer ◽

Lymph Node ◽

Cancer Patients ◽

Lymph Node Ratio ◽

Positive Lymph Node ◽

Node Positive ◽

Node Ratio ◽

Gastric Cancer Patients

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Evaluation of prognostic value and stage migration effect using positive lymph node ratio in gastric cancer

European Journal of Surgical Oncology ◽

10.1016/j.ejso.2016.08.002 ◽

2017 ◽

Vol 43 (1) ◽

pp. 203-209 ◽

Cited By ~ 10

Author(s):

S. Komatsu ◽

D. Ichikawa ◽

M. Nishimura ◽

T. Kosuga ◽

K. Okamoto ◽

...

Keyword(s):

Gastric Cancer ◽

Lymph Node ◽

Prognostic Value ◽

Lymph Node Ratio ◽

Positive Lymph Node ◽

Stage Migration ◽

Migration Effect ◽

Node Ratio

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Prognostic Significance of Metastatic Lymph Node Ratio in Patients with Gastric Cancer After Curative Gastrectomy: A Large sample, Single center Retrospective Study

10.21203/rs.3.rs-706068/v1 ◽

2021 ◽

Author(s):

Zhipeng He ◽

Dongchang Li ◽

Siyu Liu ◽

Endong Song ◽

Yida Lu ◽

...

Keyword(s):

Gastric Cancer ◽

Lymph Node ◽

Prognostic Value ◽

Lymph Node Ratio ◽

Metastatic Lymph Node ◽

Clinicopathological Characteristics ◽

Curative Gastrectomy ◽

Metastatic Lymph ◽

Node Ratio ◽

Current Guidelines

Abstract Background: The aim of this study was to examine the prognostic value of Metastatic lymph node ratio (MLNR) in patients with gastric cancer (GC) after curative gastrectomy and the potential for new indicators to strengthen the current guidelines.Methods:We retrospectively examined 3864 patients with GC who underwent curative gastrectomy between February 2011 and February 2016. Patients were classified into low-MLNR (L-MLNR), and high-MLNR (H-MLNR) groups according to adjusted X-tile cutoff-value of 0.25 for MLNR, and their clinicopathological characteristics and survival rates were compared.Results: Survival analysis indicated that MLNR was negatively associated with overall survival (OS) (P<0.001) and was an independent prognostic predictor in 3864 GC patients (P<0.001). Stratum analysis and univariate COX proportional hazards analysis were performed to validate the prognostic value of MLNR in various subgroups with clinicopathological characteristics (gender, age at surgery, tumor location, tumor size, type of gastrectomy, T stage, N stage, ELN, perineural invasion, vascular invasion, and TNM stage). MLNR is a prognostic indicator for patients with GC, regardless whether the number of lymph nodes examined is <16 or ≥16.Conclusions:The MLNR may become a new indicator for evaluating prognosis of patients with curative gastrectomy and complement the current guidelines.

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