Protection of the shelterin complex is key for tethering telomeres to the nuclear envelope during meiotic prophase I†

2019 ◽  
Vol 102 (4) ◽  
pp. 771-772
Author(s):  
Miao Li ◽  
Kui Liu
Keyword(s):  
Nuclear Envelope ◽  
Meiotic Prophase ◽  
Prophase I ◽  
Shelterin Complex ◽  
Meiotic Prophase I

scholarly journals FBXO47 regulates telomere-inner nuclear envelope integration by stabilizing TRF2 during meiosis

2019 ◽  
Author(s):  
Rong Hua ◽  
Huafang Wei ◽  
Chao Liu ◽  
Yue Zhang ◽  
Siyu Liu ◽  
...  
Keyword(s):  
Nuclear Envelope ◽  
Synaptonemal Complex ◽  
Meiotic Prophase ◽  
Homologous Chromosomes ◽  
Prophase I ◽  
Shelterin Complex ◽  
Meiotic Prophase I ◽  
F Box Protein ◽  
Bouquet Stage

Abstract During meiosis, telomere attachment to the inner nuclear envelope is required for proper pairing of homologous chromosomes and recombination. Here, we identified F-box protein 47 (FBXO47) as a regulator of the telomeric shelterin complex that is specifically expressed during meiotic prophase I. Knockout of Fbxo47 in mice leads to infertility in males. We found that the Fbxo47 deficient spermatocytes are unable to form a complete synaptonemal complex. FBXO47 interacts with TRF1/2, and the disruption of Fbxo47 destabilizes TRF2, leading to unstable telomere attachment and slow traversing through the bouquet stage. Our findings uncover a novel mechanism of FBXO47 in telomeric shelterin subunit stabilization during meiosis.

scholarly journals Nuclear Envelope-Associated Chromosome Dynamics during Meiotic Prophase I

2018 ◽  
Vol 5 ◽  
Author(s):  
Xinhua Zeng ◽  
Keqi Li ◽  
Rong Yuan ◽  
Hongfei Gao ◽  
Junling Luo ◽  
...  
Keyword(s):  
Nuclear Envelope ◽  
Meiotic Prophase ◽  
Chromosome Dynamics ◽  
Prophase I ◽  
Meiotic Prophase I

scholarly journals Speedy A–Cdk2 binding mediates initial telomere–nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation

2016 ◽  
Vol 114 (3) ◽  
pp. 592-597 ◽  
Author(s):  
Zhaowei Tu ◽  
Mustafa Bilal Bayazit ◽  
Hongbin Liu ◽  
Jingjing Zhang ◽  
Kiran Busayavalasa ◽  
...  
Keyword(s):  
Nuclear Envelope ◽  
Germ Cells ◽  
Meiotic Prophase ◽  
Homologous Pairing ◽  
Male And Female ◽  
Homologous Chromosomes ◽  
Cyclin Dependent Kinases ◽  
Prophase I ◽  
Meiotic Prophase I ◽  
Localization Domain

Telomere attachment to the nuclear envelope (NE) is a prerequisite for chromosome movement during meiotic prophase I that is required for pairing of homologous chromosomes, synapsis, and homologous recombination. Here we show that Speedy A, a noncanonical activator of cyclin-dependent kinases (Cdks), is specifically localized to telomeres in prophase I male and female germ cells in mice, and plays an essential role in the telomere–NE attachment. Deletion of Spdya in mice disrupts telomere–NE attachment, and this impairs homologous pairing and synapsis and leads to zygotene arrest in male and female germ cells. In addition, we have identified a telomere localization domain on Speedy A covering the distal N terminus and the Cdk2-binding Ringo domain, and this domain is essential for the localization of Speedy A to telomeres. Furthermore, we found that the binding of Cdk2 to Speedy A is indispensable for Cdk2’s localization on telomeres, suggesting that Speedy A and Cdk2 might be the initial components that are recruited to the NE for forming the meiotic telomere complex. However, Speedy A-Cdk2–mediated telomere–NE attachment is independent of Cdk2 activation. Our results thus indicate that Speedy A and Cdk2 might mediate the initial telomere–NE attachment for the efficient assembly of the telomere complex that is essential for meiotic prophase I progression.

scholarly journals Patterns of amyloplast distribution during microsporogenesis in Tradescantia, Impatiens and Larix

2014 ◽  
Vol 53 (4) ◽  
pp. 437-441 ◽  
Author(s):  
Bohdan Rodkiewicz ◽  
Krystyna Kudlicka ◽  
Halina Stobiecka
Keyword(s):  
Nuclear Envelope ◽  
Meiotic Prophase ◽  
Equatorial Plate ◽  
Prophase I ◽  
Meiotic Prophase I ◽  
Late Telophase ◽  
Dense Group

During the meiotic prophase I in <em>Tradescantia</em> and <em>Impatiens</em> microsporocyte becomes temporarily asymmetric, with excentrically situated nucleus and all amyloplasts gathered in a dense group close to the nuclear envelope.. Further microsporogenesis in <em>Impatiens</em> differs in amyloplast distribution from that in <em>Tradescantia</em> and <em>Larix</em>. In Impatiens at the telophase I amyloplasts are assembled in a dense equatorial plate. At the late telophase II this plate reshapes and separates a meiocyte into four areas (a tetrad) until cell plates are formed in simultaneous cytokinesis. Similar assemblages of amyloplasts do not occur in telophase meiocytes of <em>Tradescantia</em> and <em>Larix</em> where cytokinesis is of a successive type.

scholarly journals The CSN/COP9 Signalosome Regulates Synaptonemal Complex Assembly during Meiotic Prophase I of Caenorhabditis elegans

PLoS Genetics ◽  
2014 ◽  
Vol 10 (11) ◽  
pp. e1004757 ◽  
Author(s):  
Heather Brockway ◽  
Nathan Balukoff ◽  
Martha Dean ◽  
Benjamin Alleva ◽  
Sarit Smolikove
Keyword(s):  
Caenorhabditis Elegans ◽  
Synaptonemal Complex ◽  
Meiotic Prophase ◽  
Cop9 Signalosome ◽  
Complex Assembly ◽  
Prophase I ◽  
Meiotic Prophase I

Cohesin component dynamics during meiotic prophase I in mammalian oocytes

2004 ◽  
Vol 12 (3) ◽  
pp. 197-213 ◽  
Author(s):  
Ignacio Prieto ◽  
Charles Tease ◽  
Nieves Pezzi ◽  
José M. Buesa ◽  
Sagrario Ortega ◽  
...  
Keyword(s):  
Meiotic Prophase ◽  
Prophase I ◽  
Meiotic Prophase I

scholarly journals A mutation in the endonuclease domain of mouse MLH3 reveals novel roles for MutLγ during crossover formation in meiotic prophase I

PLoS Genetics ◽  
2019 ◽  
Vol 15 (6) ◽  
pp. e1008177 ◽  
Author(s):  
Melissa Toledo ◽  
Xianfei Sun ◽  
Miguel A. Brieño-Enríquez ◽  
Vandana Raghavan ◽  
Stephen Gray ◽  
...  
Keyword(s):  
Meiotic Prophase ◽  
Prophase I ◽  
Meiotic Prophase I ◽  
Endonuclease Domain

Analysis of meiotic prophase I in live mouse spermatocytes

2008 ◽  
Vol 16 (5) ◽  
pp. 743-760 ◽  
Author(s):  
Meisha A. Morelli ◽  
Uwe Werling ◽  
Winfried Edelmann ◽  
Mark S. Roberson ◽  
Paula E. Cohen
Keyword(s):  
Meiotic Prophase ◽  
Prophase I ◽  
Meiotic Prophase I ◽  
Live Mouse

scholarly journals UHRF1-repressed 5’-hydroxymethylcytosine is essential for the male meiotic prophase I

2020 ◽  
Vol 11 (2) ◽  
Author(s):  
Hongjie Pan ◽  
Ning Jiang ◽  
Shenfei Sun ◽  
Hanwei Jiang ◽  
Jianze Xu ◽  
...  
Keyword(s):  
Meiotic Prophase ◽  
Prophase I ◽  
Meiotic Prophase I
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