scholarly journals Transmission of arterial oxygen partial pressure oscillations to the cerebral microcirculation in a porcine model of acute lung injury caused by cyclic recruitment and derecruitment

2013 ◽  
Vol 110 (2) ◽  
pp. 266-273 ◽  
Author(s):  
K.U. Klein ◽  
S. Boehme ◽  
E.K. Hartmann ◽  
M. Szczyrba ◽  
L. Heylen ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Oxygen Partial Pressure ◽  
Partial Pressure ◽  
Porcine Model ◽  
Arterial Oxygen ◽  
Cerebral Microcirculation ◽  
Pressure Oscillations ◽  
Arterial Oxygen Partial Pressure ◽  
Cyclic Recruitment

scholarly journals P220 Transfer factor and arterial oxygen partial pressure are predictors of survival in hospital outpatients with COPD

Thorax ◽  
2011 ◽  
Vol 66 (Suppl 4) ◽  
pp. A157-A157
Author(s):  
A. K. Boutou ◽  
D. Shrikrishna ◽  
R. J. Tanner ◽  
C. Smith ◽  
J. L. Kelly ◽  
...  
Keyword(s):  
Oxygen Partial Pressure ◽  
Partial Pressure ◽  
Transfer Factor ◽  
Arterial Oxygen ◽  
Arterial Oxygen Partial Pressure ◽  
Hospital Outpatients

scholarly journals Low Arterial Oxygen Partial Pressure Induces Pulmonary Thrombocytopenia in Patients and a Mouse Model.

2020 ◽  
Author(s):  
Limeng Wu ◽  
Ninghong Guo ◽  
Zhenyan Xu ◽  
Wei Wang ◽  
Qinmei Xiong ◽  
...  
Keyword(s):  
Risk Factors ◽  
Mouse Model ◽  
Infectious Diseases ◽  
Oxygen Partial Pressure ◽  
Partial Pressure ◽  
Pulmonary Infection ◽  
Blood Platelet ◽  
Arterial Oxygen ◽  
Factors Associated ◽  
Arterial Oxygen Partial Pressure

Abstract Background: Recent basic studies demonstrate that the lung is a primary organ of platelet biogenesis. However, whether the pathophysiological state of the lung affect the platelets is little known. We aim to investigate the incidence of thrombocytopenia in patients with pulmonary infection (PIN) and risk factors associated with pulmonary thrombocytopenia.Methods: In total, 11941 patients with pulmonary infection (PIN) were enrolled, and patients with other three infectious diseases were collected as controls. The incidence of thrombocytopenia was compared, and the risk factors associated with thrombocytopenia in PIN patients were investigated by multivariate analysis. To explore the mechanism of thrombocytopenia, hypoxic model was constructed. Blood platelet counts from the angular vein (PLTs), left ventricle (PLTpost) and right ventricle (PLTpre) were determined. Megakaryocytes identified by anti-CD41 antibody were detected through flow cytometry and immunofluorescence.Results: The incidence of thrombocytopenia in PIN was higher than that in other three infectious diseases (9.8% vs 6.4%~5.0%, P<0.001). Low arterial oxygen partial pressure (PaO2) was an important risk factor for thrombocytopenia (OR=0.88; P<0.001). In a hypoxic mouse model, PLTs decreased (518.38±127.92 vs 840.75±77.30, P<0.05), which showed that low PaO2 induced thrombocytopenia. The difference between the PLTpost and PLTpre (△PLTpost-pre), representing the production of platelets in the lungs, was significantly attenuated in hypoxic mice when compared with normoxic mice (F=25.47, P<0.05). Additionally, proportions of CD41-positive megakaryocytes in the lungs, marrow, spleen all decreased in hypoxic mice.Conclusion: There is a high incidence for thrombocytopenia in PIN patients. Low PaO2-induced thrombocytopenia is associated with impaired generation of platelet in the lungs.

scholarly journals Low arterial oxygen partial pressure induces pulmonary thrombocytopenia in patients and a mouse model

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Limeng Wu ◽  
Ninghong Guo ◽  
Zhenyan Xu ◽  
Wei Wang ◽  
Qinmei Xiong ◽  
...  
Keyword(s):  
Risk Factors ◽  
Mouse Model ◽  
Infectious Diseases ◽  
Oxygen Partial Pressure ◽  
Partial Pressure ◽  
Pulmonary Infection ◽  
Blood Platelet ◽  
Arterial Oxygen ◽  
Factors Associated ◽  
Arterial Oxygen Partial Pressure

Abstract Background Recent basic studies demonstrate that the lung is a primary organ of platelet biogenesis. However, whether the pathophysiological state of the lung affect the platelets is little known. We aim to investigate the incidence of thrombocytopenia in patients with pulmonary infection (PIN) and risk factors associated with pulmonary thrombocytopenia. Methods In total, 11,941 patients with pulmonary infection (PIN) were enrolled, and patients with other three infectious diseases were collected as controls. The incidence of thrombocytopenia was compared, and the risk factors associated with thrombocytopenia in PIN patients were investigated by multivariate analysis. To explore the mechanism of thrombocytopenia, hypoxic model was constructed. Blood platelet counts from the angular vein (PLTs), left ventricle (PLTpost) and right ventricle (PLTpre) were determined. Megakaryocytes identified by anti-CD41 antibody were detected through flow cytometry and immunofluorescence. Results The incidence of thrombocytopenia in PIN was higher than that in other three infectious diseases (9.8% vs. 6.4% ~ 5.0%, P < 0.001). Low arterial oxygen partial pressure (PaO2) was an important risk factor for thrombocytopenia (OR = 0.88; P < 0.001). In a hypoxic mouse model, PLTs decreased (518.38 ± 127.92 vs 840.75 ± 77.30, P < 0.05), which showed that low PaO2 induced thrombocytopenia. The difference between the PLTpost and PLTpre (∆PLTpost-pre), representing the production of platelets in the lungs, was significantly attenuated in hypoxic mice when compared with normoxic mice (F = 25.47, P < 0.05). Additionally, proportions of CD41-positive megakaryocytes in the lungs, marrow, spleen all decreased in hypoxic mice. Conclusion There is a high incidence for thrombocytopenia in PIN patients. Low PaO2-induced thrombocytopenia is associated with impaired generation of platelet in the lungs.

scholarly journals High Oxygen Partial Pressure Decreases Anemia-induced Heart Rate Increase Equivalent to Transfusion

2011 ◽  
Vol 115 (3) ◽  
pp. 492-498 ◽  
Author(s):  
John R. Feiner ◽  
Heather E. Finlay-Morreale ◽  
Pearl Toy ◽  
Jeremy A. Lieberman ◽  
Maurene K. Viele ◽  
...  
Keyword(s):  
Heart Rate ◽  
Oxygen Partial Pressure ◽  
Partial Pressure ◽  
Hemoglobin Concentration ◽  
Arterial Oxygen ◽  
High Oxygen Partial Pressure ◽  
Oxygen Fraction ◽  
Arterial Oxygen Partial Pressure ◽  
Fraction Versus ◽  
Inspired Oxygen

Background Anemia is associated with morbidity and mortality and frequently leads to transfusion of erythrocytes. The authors sought to directly compare the effect of high inspired oxygen fraction versus transfusion of erythrocytes on the anemia-induced increased heart rate (HR) in humans undergoing experimental acute isovolemic anemia. Methods The authors combined HR data from healthy subjects undergoing experimental isovolemic anemia in seven studies performed by the group. HR changes associated with breathing 100% oxygen by nonrebreathing facemask versus transfusion of erythrocytes at their nadir hemoglobin concentration of 5 g/dl were examined. Data were analyzed using a mixed-effects model. Results HR had an inverse linear relationship to hemoglobin concentration with a mean increase of 3.9 beats per min per gram of hemoglobin (beats/min/g hemoglobin) decrease (95% CI, 3.7-4.1 beats/min/g hemoglobin), P &lt; 0.0001. Return of autologous erythrocytes significantly decreased HR by 5.3 beats/min/g hemoglobin (95% CI, 3.8-6.8 beats/min/g hemoglobin) increase, P &lt; 0.0001. HR at nadir hemoglobin of 5.6 g/dl (95% CI, 5.5-5.7 g/dl) when breathing air (91.4 beats/min; 95% CI, 87.6-95.2 beats/min) was reduced by breathing 100% oxygen (83.0 beats/min; 95% CI, 79.0-87.0 beats/min), P &lt; 0.0001. The HR at hemoglobin 5.6 g/dl when breathing oxygen was equivalent to the HR at hemoglobin 8.9 g/dl when breathing air. Conclusions High arterial oxygen partial pressure reverses the heart rate response to anemia, probably because of its usability rather than its effect on total oxygen content. The benefit of high arterial oxygen partial pressure has significant potential clinical implications for the acute treatment of anemia and results of transfusion trials.

scholarly journals Low Arterial Oxygen Partial Pressure Induces Pulmonary Thrombocytopenia in Patients and a Mouse Model

2020 ◽  
Author(s):  
Limeng Wu ◽  
Ninghong Guo ◽  
Zhenyan Xu ◽  
Wei Wang ◽  
Qinmei Xiong ◽  
...  
Keyword(s):  
Risk Factors ◽  
Mouse Model ◽  
Oxygen Partial Pressure ◽  
Partial Pressure ◽  
Pulmonary Infection ◽  
Blood Platelet ◽  
Arterial Oxygen ◽  
Factors Associated ◽  
Arterial Oxygen Partial Pressure ◽  
The Difference

Abstract Background Recent basic studies demonstrate that the lung is a primary organ of platelet biogenesis. However, whether the pathophysiological state of the lung affect the platelets is little known. We aim to investigate the incidence of thrombocytopenia in patients with pulmonary infection (PIN) and risk factors associated with pulmonary thrombocytopenia. Methods In total, 11941 patients with pulmonary infection (PIN) were enrolled, and patients with three other infectious diseases were collected as controls. The incidence of thrombocytopenia was compared, and the risk factors associated with thrombocytopenia in PIN patients were investigated by multivariate analysis. To explore the mechanism of thrombocytopenia, hypoxic model were constructed. Blood platelet counts from the angular vein (PLTs), left ventricle (PLTpost) and right ventricle (PLTpre) were determined. Megakaryocyte staining with a CD41-specific antibody in the lungs was detected by flow cytometry and immunofluorescence. Results The incidence of thrombocytopenia in PIN patients was higher than that in the other three types of infectious disease patients(9.8% vs 6.4%~5.0%, P < 0.001). Relatively low arterial oxygen partial pressure (PaO2) was an important risk factor for thrombocytopenia (OR = 0.88; P < 0.001). In a hypoxic mouse model, PLTs were decreased (518.38 ± 127.92 vs 840.75 ± 77.30, P < 0.05), which showed that the low PaO2 could induce thrombocytopenia. The difference between the PLTpost and PLTpre (△PLTpost−pre) represented the production of platelets in the lungs, which was significantly attenuated in hypoxic mice compared with normoxic mice (F = 25.47, P < 0.05). Additionally, CD41-positive megakaryocyte numbers in the lungs were decreased in hypoxic mice. Conclusion PIN is a susceptibility factor for thrombocytopenia. Low PaO2-induced thrombocytopenia is associated with impaired platelet generation in the lungs.

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