1153 “To FNA Or to Not FNA, That Is the Question.” A 5-Year Retrospective Epidemiological Study Of 238 Surgical Parotid Cases Treated at An East Yorkshire OMFS Unit

Abstract Introduction Fine needle aspiration (FNA) is a surgical procedure used to aid with diagnosis and subsequent treatment planning. This study compares FNA histology with final histology (gold standard) for diagnostic accuracy in parotid surgery patients. Method A retrospective investigation of patient records from January 2014-January 2019 was performed to find eligible patients that underwent parotid surgery. Histology reports of the ultrasound (US) FNA and final parotid sample were compared for diagnostic accuracy and ability to differentiate between malignant & benign tumours. Results 240 parotid surgeries on 238 patients were undertaken between 2014-2019 under OMFS and ENT specialities. 137 US FNA’s were performed, of these, there was an 85% diagnostic rate. Of the diagnostic FNA’s 79% reach gold standard, with the histology matching that of the final histology. Of the 24 without diagnostic accuracy, 2/3 were still able to differentiate between malignant and benign lesions. Overall, the US FNA’s were able to differentiate malignant and benign parotid lesions in 93% of cases. Conclusions The audit has proven US FNA to be an accurate diagnostic test, it gives extra data to aid in the decision making and planning for parotid surgeries. Although US FNA has shown to be more accurate in diagnosing benign parotid tumours; it is useful in detecting cellular change which could be indicative of malignancy.

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Role of FNAC in soft tissue tumors and its histopathological correlation

International Surgery Journal ◽

10.18203/2349-2902.isj20173402 ◽

2017 ◽

Vol 4 (8) ◽

pp. 2632

Author(s):

Veenu Jain ◽

Tarun Agarwal

Keyword(s):

Soft Tissue ◽

Diagnostic Accuracy ◽

Paraffin Section ◽

Needle Aspiration ◽

Soft Tissue Tumors ◽

Age Group ◽

Malignant Tumours ◽

Soft Tissue Tumours ◽

Histopathological Correlation ◽

Benign Tumours

Background: Soft tissue tumours are very rare. They are diagnosed initially by Fine needle aspiration cytology (FNAC). The present study was conducted with the aim to study the acceptability and diagnostic accuracy of cytodiagnosis in soft tissue lesions, to evaluate the reliability of cytodianosis as compared conventional histological paraffin section and to assess nuclear grade in various soft tissue lesions.Methods: The present study was conducted on 140 patients of soft tissue tumours during the period from August 2002 to July 2003 in the Department of pathology and microbiology, LLRM medical college, Meerut. FNAC was done in 132 cases and histopathology was conducted in 86 cases and correlation of those results was done.Results: Diagnosis of STT by FNAC was done in 132 cases. In benign tumours maximum number of cases (28) was in the age group of 20-29 years and in malignant tumours maximum number of cases (7) was in the age group of 40-49 years. 110 (83.3%) cases were benign and 22 (16.7%) cases were found to be malignant. Maximum number of STT was observed in trunk followed by limb extremities. Male preponderance was observed in the study. The overall accuracy of the present study was 97.7%. Accuracy for diagnosing benign soft tissue tumours was 100% and for malignant STT was 94.5%. The sensitivity, specificity and predictive value of the present study was 100%, 98.6% and 93.3%.Conclusions: FNAC plays a very important role in initial diagnosis of soft tissue tumours. It provided acceptable diagnostic accuracy when supported by histopathology.

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Diagnostic Accuracy of Elastography in Differentiating Benign from Malignant Thyroid Nodules Taking Fine Needle Aspiration Cytology as Gold Standard

Journal of Bahria University Medical and Dental College ◽

10.51985/olbl1894 ◽

2021 ◽

Vol 11 (02) ◽

pp. 70-75

Author(s):

Ameet Jesrani ◽

Marya Hameed ◽

Naveed Ahmed ◽

Pooja Devi ◽

Abdul Baseer

Keyword(s):

Diagnostic Accuracy ◽

Fine Needle Aspiration ◽

Gold Standard ◽

Thyroid Nodules ◽

Needle Aspiration ◽

Categorical Variables ◽

Aspiration Cytology ◽

Fine Needle ◽

Strain Elastography ◽

Needle Aspiration Cytology

Objective: To evaluate the diagnostic accuracy of Strain Elastography in differentiating benign from malignant thyroid nodules taking fine needle aspiration cytology as gold standard. Study Design and Setting: It was a cross sectional study conducted at Radiology department of Jinnah Postgraduate Medical Centre, Karachi from May 2019 to June 2020 Methodology: Total 586 patients with complaints of swelling in region of thyroid gland were enrolled in study on which Strain Elastography was performed using linear transducer with ultrasound frequency of 7.5 MHz. The results of strain Elastography were compared with histopathology. All the information was recorded into predesigned proforma. Chi-square test was used for comparison among categorical variables and when it has not worked then imitation of Monte Carlos was applied and to see agreement among various categorical variables Kappa statistics were performed. Level of statistical significance was accepted as P < 0.05. Results: The sensitivity of 100%, specificity of 80.2%, positive predictive value of 61.7%, negative predictive value of 100%, and diagnostic accuracy of 85% of elastography was calculated in differentiation among benign from malignant thyroid nodules. Conclusion: Strain elastography is noninvasive technique which can be used to characterize thyroid nodules and helps in differentiating benign from malignant thyroid nodules and can limit the utilization of invasive technique like FNAC and helps in selection of patients which needs surgery.

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Diagnostic accuracy of tuberculous lymphadenitis fine needle aspiration biopsy confirmed by PCR as gold standard

IOP Conference Series Earth and Environmental Science ◽

10.1088/1755-1315/125/1/012048 ◽

2018 ◽

Vol 125 ◽

pp. 012048

Author(s):

DSuryadi ◽

Delyuzar ◽

Soekimin

Keyword(s):

Diagnostic Accuracy ◽

Fine Needle Aspiration ◽

Gold Standard ◽

Fine Needle Aspiration Biopsy ◽

Needle Aspiration ◽

Aspiration Biopsy ◽

Tuberculous Lymphadenitis ◽

Fine Needle ◽

Needle Aspiration Biopsy

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Diagnostic Accuracy of Fine Needle Aspiration Cytology in Parotid Tumours

Acta Otorrinolaringologica (English Edition) ◽

10.1016/j.otoeng.2014.05.005 ◽

2014 ◽

Vol 65 (3) ◽

pp. 157-161 ◽

Cited By ~ 4

Author(s):

Vanessa Zerpa Zerpa ◽

Maria Teresa Cuesta Gonzáles ◽

Gabriela Agostini Porras ◽

Martin Marcano Acuña ◽

Enrique Estellés Ferriol ◽

...

Keyword(s):

Diagnostic Accuracy ◽

Fine Needle Aspiration ◽

Fine Needle Aspiration Cytology ◽

Needle Aspiration ◽

Aspiration Cytology ◽

Fine Needle ◽

Needle Aspiration Cytology ◽

Parotid Tumours

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Diagnostic accuracy of ultrasonography versus fine-needle-aspiration cytology for predicting benign thyroid lesions

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.35.3.292 ◽

2019 ◽

Vol 35 (3) ◽

Author(s):

Sultan Abdulwadoud Alshoabi ◽

Abdulkhaleq Ayedh Binnuhaid

Keyword(s):

Diagnostic Accuracy ◽

Fine Needle Aspiration ◽

Fine Needle Aspiration Cytology ◽

Needle Aspiration ◽

Aspiration Cytology ◽

Fine Needle ◽

The Us ◽

Needle Aspiration Cytology ◽

Benign Thyroid ◽

Thyroid Lesions

Background and Objective: Thyroid nodules (TNs) are abnormal growths of thyroid cells that form masses within the thyroid gland. TNs are common, and the importance lies in need to exclude thyroid cancer. This study was intended to evaluate the diagnostic accuracy of ultrasonography for differentiating benign from malignant thyroid lesions in comparison with fine-needle aspiration cytology (FNA cytology). Methods: This study involved 133 patients with thyroid lesions. All patients underwent thyroid ultrasonography and ultrasound (US)-guided-FNA cytology and results were compared. Results: Out of 133 patients included in this study, the mean age was 41.2±15 years, and 113 (85%) were female. Thyroid lesions were benign in 126 cases (94.7%) and malignant in nine cases (5.3%). Among 124 patients with thyroid lesions diagnosed as benign with US, 122 (98.38%) were confirmed to be benign with FNA cytology, and only 2 (1.6%) were proved to be malignant. Among nine patients with thyroid lesions diagnosed as malignant by US, 5 (55.6%) were confirmed to be malignant by FNA cytology, and 4 (44.4%) were proved to be benign. The US diagnosed benign thyroid lesions with a sensitivity, specificity, positive predictive value, and negative predictive value of 98.38%, 71.42%, 98.38%, and 55.55%, respectively. The results revealed strong compatibility between diagnosis of benign thyroid lesions by the US and proved diagnosis by FNA cytology (p<0.001). Conclusion: B-mode ultrasonography is a valuable tool in differentiating benign from malignant thyroid lesions. It can almost always predict the benign nature of thyroid lesions with excellent diagnostic accuracy. doi: https://doi.org/10.12669/pjms.35.3.292 How to cite this:Alshoabi SA, Binnuhaid AA. Diagnostic accuracy of ultrasonography versus fine-needle-aspiration cytology for predicting benign thyroid lesions. Pak J Med Sci. 2019;35(3):---------. doi: https://doi.org/10.12669/pjms.35.3.292 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Efficacy of Fine Needle Aspiration and Cytology in Solitary Thyroid Nodule

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i1731300 ◽

2021 ◽

pp. 1-6

Author(s):

Shahzad Asfandyar Haider ◽

Samar Memon ◽

Muhammad Saleem Laghari ◽

Ahsan Ali Laghari ◽

Mujeeb-Ur- Rehman Laghari ◽

...

Keyword(s):

Diagnostic Accuracy ◽

Fine Needle Aspiration ◽

Gold Standard ◽

Cystic Lesion ◽

Thyroid Nodules ◽

Needle Aspiration ◽

Thyroid Function Tests ◽

Care Hospital ◽

Female Ratio ◽

Fine Needle

Objective: To determine the efficacy of fine needle aspiration and cytology (FNAC) in the solitary thyroid nodules at tertiary care Hospital. Materials and Methods: This study was conducted in department of general surgery at Liaquat University Hospital Jamshoro/ Hyderabad during one year from June 2015 May 2016. The study included all subjects of any gender and age who had a solitary nodule that was confirmed clinically or through thyroid scan. To achieve a tissue diagnosis before surgery, the study participants experienced fine needle aspiration cytology (FNAC). The resected specimens were submitted for histopathology investigation postoperatively. Diagnostic accuracy of FNAC was assessed by cross tabulation by taking histopathology as gold standard. The data was gathered by using a self-made proforma and analyzed with SPSS version 20. Results: Total fifty solitary thyroid nodules (STN) patients were studied. Mean age of the patients was 34.54+10.3 years. Of 50 patients, 46(92%) & 4(8%) were females and males respectively with male & female ratio of 1:11.5. 28(56%) STN were on right lobe, left side in 19(38%) cases; on isthmus in 3 (6%) cases. As per FNAC results, nodular colloid goiters were seen in 66% cases, follicular neoplasm in 10%, papillary carcinoma in 10%, Hurthle cell variation in 6%, benign cystic lesion in 4% of cases, neoplastic cystic lesion in only 1 case, and also only 1 study subject was suspected for malignancy. Thyroid function tests were normal in all patients. FNAC showed a significant efficacy with 83.3% sensitivity, 86.8% specificity, 86% diagnostic accuracy, 66.6% PPV and 94.28% NPV when histopathology was taken as a gold standard. Conclusion: In the conclusion of this study the FNAC observed to be a simple, safe and effective diagnostic tool in detecting the thyroid malignancies as solitary thyroid nodules with 83.3% and 86.8% sensitivity and specificity respectively.

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