Breast cancer (BC) has recently surpassed lung canceras the most frequently diagnosed cancer worldwide,with an estimated 19.3 million new cases and almost 10 1 million deaths occurring in 2020. A steady ascension in BC incidence has been a remarkable feature in cancer epidemiology for almost a century, and has been reported in richer as well as poorer communities all over the world. This trend is no doubt associated with the ageing of the global population: “Each one-year increase of population ageing (is) associated with a nearly ½ year increase of age at BC diagnosis.