scholarly journals P-EGS03 Curious Case of Life Threatening Gastrointestinal Bleed

2021 ◽  
Vol 108 (Supplement_9) ◽  
Author(s):  
VIBHA SINGH
Keyword(s):  
Arteriovenous Malformation ◽  
Gastrointestinal Stromal Tumors ◽  
Severe Anaemia ◽  
Intestinal Bleeding ◽  
Cross Sectional ◽  
Stromal Tumors ◽  
Cross Sectional Imaging ◽  
Life Threatening ◽  
Cells Of Cajal ◽  
Resection And Anastomosis

Abstract Background Gastrointestinal stromal tumors are mesenchymal in origin, being derived from the interstitial cells of Cajal. These can be found anywhere in the gastrointestinal tract and are commonly found in the stomach followed by the small bowel. Gastrointestinal stromal tumors are usually asymptomatic and are often found incidentally. Chronic bleeding is one of the most common presentation. Gastrointestinal stromal tumors presenting with massive gastro intestinal haemorrhage and mimicking arteriovenous malformation on radiology are rare with only few cases reported. Methods Herein we present such a case of a 45-year-old gentleman with massive gastro intestinal bleeding. At presentation, patient was in congestive heart failure due to severe anaemia with a hemoglobin of 2.9g/dL. CECT Angiography localised the bleed to be from a jejunal mass lesion with radiological features consistent with those of arteriovenous malformation. Patient underwent laparoscopy assisted resection and anastomosis. Results Histopathology examination revealed a low risk jejunal gastrointestinal stromal tumor with no evidence of arteriovenous malformation. The mass was removed completely and the patient was discharged on 5th post-operative day. Patient was followed up in the out-patient department and was found to be doing well. Conclusions Gastrointestinal stromal tumors though relatively uncommon should be kept as important differentials for acute torrential gastrointestinal bleeding. It is highlighted that a presentation of gastrointestinal stromal tumors similar to that of arteriovenous malformations on cross sectional imaging should be kept in mind. The present case is reported in hope of expanding the knowledge of a rare occurrence, its aetiology, clinical impact and treatment.

scholarly journals Retroperitoneal Extragastrointestinal Stromal Tumor: Radiologic Pathologic Correlation

2014 ◽  
Vol 4 ◽  
pp. 34 ◽  
Author(s):  
Pankaj Watal ◽  
Swetang G. Brahmbhatt ◽  
Prashant J. Thoriya ◽  
Nandini U. Bahri
Keyword(s):  
Gastrointestinal Tract ◽  
Gastrointestinal Stromal Tumors ◽  
Cross Sectional ◽  
Stromal Tumors ◽  
Extragastrointestinal Stromal Tumor ◽  
Cross Sectional Imaging ◽  
Rare Site ◽  
Sectional Imaging ◽  
Histopathologic Findings ◽  
Histology And Immunohistochemistry

Neoplasms with histology and immunohistochemistry similar to gastrointestinal stromal tumors may occur primarily outside the gastrointestinal tract, usually in the omentum and mesentery. These are referred to as extragastrointestinal stromal tumors (EGISTs). Retroperitoneum is a very rare site for such neoplasms. We report a patient with EGIST in the retroperitoneum, elaborating the cross-sectional imaging and histopathologic findings.

scholarly journals Jejunal gastrointestinal stromal tumors masquerading as an appendicular mass: an unusual presentation

2020 ◽  
Vol 7 (8) ◽  
pp. 2769
Author(s):  
Rajat R. Choudhari ◽  
Annagiri Raghavendra ◽  
Harish Rao Kalbavi
Keyword(s):  
Small Bowel ◽  
Gastrointestinal Stromal Tumors ◽  
Case Reports ◽  
Iliac Fossa ◽  
Unusual Presentation ◽  
Gi Bleeding ◽  
Stromal Tumors ◽  
Cells Of Cajal ◽  
Resection And Anastomosis ◽  
Appendicular Mass

Gastrointestinal stromal tumors (GISTs) are a rare variety of tumors of mesenchymal origin found in the gastrointestinal (GI) tract forming about 1% of all GI tumors. These originate from the interstitial cells of Cajal. Small bowel GISTs have been shown to present as obscure GI bleeding, obstruction and perforation in literature. We report a 57 years old female patient presenting with pain abdomen, fever and vomiting and palpable right iliac fossa (RIF) mass diagnosed as an appendicular mass and managed conservatively. She was planned interval appendicectomy and was discovered to have a jejunal GIST at laparotomy treated with resection and anastomosis. There are case reports of small bowel GISTs presenting as sources of obscure or overt GI bleeding and luminal or extra luminal mass causing small bowel obstruction. Surgery is mainstay of treatment with imatinib for adjuvant or neoadjuvant therapy. This case highlights an unusual presentation of a jejunal GIST with a sealed off perforation mimicking an appendicular mass in the RIF treated by surgical resection followed by adjuvant Imatinib therapy. GIST being an uncommon tumor with varied presentations can lead to misdiagnosis and delays in treatment. This differential should be kept in mind while evaluating small bowel pathologies to aid a timely diagnosis.   

Imatinib in the Management of Multiple Gastrointestinal Stromal Tumors Associated With a Germline KIT K642E Mutation

2007 ◽  
Vol 131 (9) ◽  
pp. 1393-1396
Author(s):  
Janet Graham ◽  
Maria Debiec-Rychter ◽  
Christopher L. Corless ◽  
Robin Reid ◽  
Rosemarie Davidson ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumors ◽  
Interstitial Cells Of Cajal ◽  
Germline Mutations ◽  
Mesenchymal Tumors ◽  
Stromal Tumors ◽  
Pdgfra Gene ◽  
Oncogenic Mutations ◽  
Esophageal Tumors ◽  
Exon 11 ◽  
Cells Of Cajal

Abstract Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gut and are distinguished by expression of CD117 (c-Kit). Oncogenic mutations in the KIT or PDGFRA gene are detected in approximately 85% of sporadic GISTs. In recent years, examples of familial GIST have been reported in which germline mutations of KIT or PDGFRA result in multiple GISTs, skin disorders, and other abnormalities. The most common germline mutations are in KIT exon 11, mutations in exons 8 and 17 have also been described, and there are 2 families with germline PDGFRA mutations. We present a case in which a germline KIT exon 13 mutation (K642E) was discovered in a patient with multiple GISTs of rectum, small intestine, and esophagus, as well as diffuse hyperplasia of the interstitial cells of Cajal. To our knowledge, this is only the second germline example of this particular mutation. The patient's esophageal tumors were stabilized with imatinib.

scholarly journals Phosphodiesterase 3A: a new player in development of interstitial cells of Cajal and a prospective target in gastrointestinal stromal tumors (GIST)

Oncotarget ◽  
2017 ◽  
Vol 8 (25) ◽  
pp. 41026-41043 ◽  
Author(s):  
Pierre Vandenberghe ◽  
Perrine Hagué ◽  
Steven C. Hockman ◽  
Vincent C. Manganiello ◽  
Pieter Demetter ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumors ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Stromal Tumors ◽  
Cells Of Cajal

266 Accelerated Turnover of Interstitial Cells of Cajal (ICC) from Local Progenitors in a Mouse Model of Gastrointestinal Stromal Tumors (GIST)

2009 ◽  
Vol 136 (5) ◽  
pp. A-51
Author(s):  
Michael R. Bardsley ◽  
Laura Popko ◽  
David L. Young ◽  
Gianrico Farrugia ◽  
Brian P. Rubin ◽  
...  
Keyword(s):  
Mouse Model ◽  
Gastrointestinal Stromal Tumors ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Stromal Tumors ◽  
Cells Of Cajal

Large Omental Metastases of a Gastrointestinal Stromal Tumor

Medicina ◽  
2011 ◽  
Vol 47 (11) ◽  
pp. 86
Author(s):  
Povilas Ignatavičius ◽  
Tomas Petraitis ◽  
Žilvinas Saladžinskas ◽  
Lilija Butkevičienė ◽  
Kristina Žvinienė
Keyword(s):  
Case Report ◽  
Gastrointestinal Tract ◽  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Stromal Tumors ◽  
Interstitial Cells Of Cajal ◽  
Metastatic Tumor ◽  
Stromal Tumor ◽  
Mesenchymal Tumors ◽  
Stromal Tumors ◽  
Cells Of Cajal

Gastrointestinal stromal tumors are rare tumors, originating from the interstitial cells of Cajal. They are the most common mesenchymal tumors of the gastrointestinal tract. Metastatic tumor is treated with imatinib mesylate. A case of large metastases of a gastrointestinal stromal tumor to the omentum, diagnosis and treatment principles are presented in this case report.

Gallbladder GIST: A review of literature

2019 ◽  
Vol 92 (1) ◽  
pp. 1-5
Author(s):  
Ashish Gupta
Keyword(s):  
Gastrointestinal Stromal Tumors ◽  
Interstitial Cells Of Cajal ◽  
Case Reports ◽  
Gallbladder Wall ◽  
Postoperative Adjuvant Therapy ◽  
Review Of Literature ◽  
Mesenchymal Tumors ◽  
Stromal Tumors ◽  
Extensive Search ◽  
Cells Of Cajal

Mesenchymal tumors of the gallbladder are rarely encountered in clinical practice. The Gastrointestinal Stromal tumors(GIST) of the gallbladder are rarely encountered. These tumors most commonly arise from the interstitial cells of cajal(ICC), the pacemakers of the intestinal system. There can be benign as well as malignant form of GIST .The literature on GIST arising from the gallbladder wall is limited to few case reports only.on extensive search of the indexed literature only 9 cases of gallbladder GIST were retrieved. Based on the available literature these tumors are commonly found in females. They usually present with hypochondrial pain with or without other features of cholangitis. These tumors are usually malignant and warrant a radical surgical excision.The data on postoperative adjuvant therapy and survival is limited. The authors are presenting a review of the available literature on this rare pathology.

scholarly journals Expression of the Intermediate Filament Nestin in Gastrointestinal Stromal Tumors and Interstitial Cells of Cajal

2001 ◽  
Vol 158 (3) ◽  
pp. 817-823 ◽  
Author(s):  
Tohru Tsujimura ◽  
Chiaki Makiishi-Shimobayashi ◽  
Johan Lundkvist ◽  
Urban Lendahl ◽  
Keiji Nakasho ◽  
...  
Keyword(s):  
Intermediate Filament ◽  
Gastrointestinal Stromal Tumors ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Stromal Tumors ◽  
Cells Of Cajal

scholarly journals Diagnosis and classification of non-epithelial stomach tumors at Viet Duc University Hospital

2020 ◽  
Vol 10 (5) ◽  
Author(s):  
Minh Đức Hoàng ◽  
Keyword(s):  
Gastrointestinal Stromal Tumors ◽  
Gastric Wall ◽  
Diagnostic Methods ◽  
University Hospital ◽  
Ct Scanner ◽  
Cross Sectional ◽  
Female Ratio ◽  
Stromal Tumors ◽  
Epithelial Tumors ◽  
Stomach Tumors

Abstract Introduction: To diagnose and classify for non-epithelial tumors of the stomach was difficult for physicians because of its non-specific symptoms and intensive diagnostic methods. Materials and Methods: Descriptive cross-sectional retrospective study, monitoring cases of non-epithelial tumors of the stomach surgery at Viet Duc University Hospital from 4/2014 to 5/2019. Results: In 144 cases of non-epithelial tumors of the stomach, there were 122 cases of GIST (stromal tumors had most rate 62,5%), 22 cases of gastric lymphomas, the average age was 56.9, male/female ratio was 1/1, however GIST and lymphomas being seen more in man than woman, in other side, leiomyomas and Schwann tumors being seen more in woman than a man. Diagnosis of non-epithelial gastric tumors mostly by endoscopy (87.9% tumors discovered), by ultrasound through endoscopy (100% tumors found, in that, 2 cases of lymphomas seen with the thick gastric wall), by belly ultrasound (79/113 cases, 59.4%), by CT-Scanner (100% tumors found). Diagnosis of classifying tumor by pathology: Lymphomas (100%), gastrointestinal stromal tumors (GIST) only classified by immunohistochemistry (IHC): stromal tumors (positive marker DOG1 100%, CD17 96,9%, CD34 92,9%), leiomyomas (positive marker Desmin 100%, SMA 90%), Schwann tumors (positive marker S100 100%). Conclusions: Common non-epithelial stomach tumors at Viet Duc University Hospital are stromal tumors, lymphoma, Schwann’s tumors, smooth muscle tumors also fat tumors. Diagnosis is confirmed based on disease anatomy and immunohistochemistry results with markers DOG1, CD17, CD34, Desmin, SMA, S100. Keywords: Non-epithelial tumors of the stomach, diagnose, classify, gastrointestinal stromal tumors (GIST), lymphomas, leiomyomas, Schwann tumors. Tóm tắt Đặt vấn đề: Chẩn đoán và phân loại các u dạ dày không biểu mô là một vấn đề khó đối với thầy thuốc bởi các triệu chứng thường không đặc hiệu và phương pháp chẩn đoán chuyên sâu. Phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang hồi cứu các trường hợp phẫu thuật u dạ dày không biểu mô tại Bệnh viện Hữu nghị Việt Đức từ tháng Kết quả: Có 144 người bệnh u dạ dày không biểu mô được phẫu thuật tại Bệnh viện Hữu nghị Việt Đức, trong đó có 122 người bệnh u trung mô (trong đó u mô đệm chiếm nhiều nhất 62,5%), 22 trường hợp u lympho, nhóm nghiên cứu có tuổi trung bình là 56,9, tỷ lệ nam/nữ là 1/1. Tuy nhiên u mô đệm và u lympho gặp ở nam nhiều hơn ở nữ và ngược lại, u cơ trơn và u Schwann gặp ở nữ nhiều hơn ở nam. Chẩn đoán u dạ dày không biểu mô chủ yếu bằng nội soi (87,9% phát hiện u trên nội soi), siêu âm nội soi (100% trường hợp phát hiện u, trong đó 2 trường hợp u lympho thấy dày thành dạ dày), siêu âm ổ bụng (79/133 trường hợp, 59,4%), chụp cắt lớp vi tính (100% phát hiện ra u). Chẩn đoán xác định loại u dựa vào kết quả giải phẫu bệnh: U lympho (100%), các loại u trung mô khác phải dựa vào hoá mô miễn dịch: u mô đệm (dương tính với dấu ấn DOG1 là 100%, CD17 là 96,9%, CD34 là 92,9%), u cơ trơn (dương tính với dấu ấn Desmin 100%, SMA là 90%), u Schwann (dương tính với S100 là 100%). Kết luận: U dạ dày không biểu mô thường gặp tại Bệnh viện Hữu nghị Việt Đức là u mô đệm, u lympho, u Schwann, u cơ trơn và u mỡ. Chẩn đoán xác định dựa vào giải phẫu bệnh và kết quả hoá mô miễn dịch với các dấu ấn DOG1, CD17, CD34, Desmin, SMA, S100.

scholarly journals Pulmonary Arterial Dilatation: Imaging Evaluation Using Multidetector Computed Tomography

2021 ◽  
Author(s):  
Sreenivasa Narayana Raju ◽  
Niraj Nirmal Pandey ◽  
Arun Sharma ◽  
Amarinder Singh Malhi ◽  
Siddharthan Deepti ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
Bronchial Tree ◽  
Pulmonary Angiography ◽  
Ct Pulmonary Angiography ◽  
Imaging Evaluation ◽  
Cross Sectional ◽  
Clinical Background ◽  
Cross Sectional Imaging ◽  
Life Threatening ◽  
Pulmonary Arterial

AbstractPulmonary artery dilatation comprises a heterogeneous group of disorders. Early diagnosis is important as the presentation may be incidental, chronic, or acute and life threatening depending upon the etiology. Cross-sectional imaging plays an important role, with CT pulmonary angiography being regarded as the first line investigation in the evaluation of pulmonary artery pathologies. Moreover, effects of pulmonary artery lesions on proximal and distal circulation can also be ascertained with the detection of associated conditions. Special attention should also be given to the left main coronary artery and the trachea-bronchial tree as they may be extrinsically compressed by the dilated pulmonary artery. In context of an appropriate clinical background, CT pulmonary angiography also helps in treatment planning, prognostication, and follow-up of these patients. This review mainly deals with imaging evaluation of the pulmonary arterial dilatations on CT with emphasis on the gamut of etiologies in the adult as well as pediatric populations.

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