scholarly journals Blood T-cell receptor   chain transcriptome in multiple sclerosis. Characterization of the T cells with altered CDR3 length distribution

Brain ◽  
2004 ◽  
Vol 127 (5) ◽  
pp. 981-995 ◽  
Author(s):  
D.-A. Laplaud
1991 ◽  
Vol 174 (4) ◽  
pp. 891-900 ◽  
Author(s):  
S M Friedman ◽  
M K Crow ◽  
J R Tumang ◽  
M Tumang ◽  
Y Q Xu ◽  
...  

While all known microbial superantigens are mitogenic for human peripheral blood lymphocytes (PBL), the functional response induced by Mycoplasma arthritidis-derived superantigen (MAM) is unique in that MAM stimulation of PBL consistently results in T cell-dependent B cell activation characterized by polyclonal IgM and IgG production. These immunostimulatory effects of MAM on the humoral arm of the human immune system warranted a more precise characterization of MAM-reactive human T cells. Using an uncloned MAM reactive human T cell line as immunogen, we have generated a monoclonal antibody (mAb) (termed C1) specific for the T cell receptor V beta gene expressed by the major fraction of MAM-reactive human T cells, V beta 17. In addition, a V beta 17- MAM-reactive T cell population exists, assessed by MAM, induced T cell proliferation and cytotoxic T cell activity. mAb C1 will be useful in characterizing the functional properties of V beta 17+ T cells and their potential role in autoimmune disease.


1992 ◽  
Vol 22 (2) ◽  
pp. 491-498 ◽  
Author(s):  
Angel Ezquerra ◽  
David B. Wilde ◽  
Thomas J. McConnell ◽  
Knut Sturmhöfel ◽  
Robert B. Valas ◽  
...  

2015 ◽  
Vol 295 (2) ◽  
pp. 99-104 ◽  
Author(s):  
Heikki J. Niemi ◽  
Sini Laakso ◽  
Jukka T. Salminen ◽  
T. Petteri Arstila ◽  
Anni Tuulasvaara

1995 ◽  
Vol 756 (1 T-Cell Recept) ◽  
pp. 406-409 ◽  
Author(s):  
KALLE SÖDERSTRÖM ◽  
ANDERS BUCHT ◽  
EVA HALAPI ◽  
CARINA LUNDQVIST ◽  
ALVAR GRÖNBERG ◽  
...  

1996 ◽  
Vol 26 (6) ◽  
pp. 1328-1334 ◽  
Author(s):  
Yoh Matsumoto ◽  
Satoshi Abe ◽  
Masanori Tsuchida ◽  
Hirouki Hirahara ◽  
Toru Abo ◽  
...  

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