Reply: Is there evidence of a subordinate role of the hippocampal CA1 field for declarative memory formation?

Prevailing theories link prefrontal cortex (PFC) maturation to the development of declarative memory. However, the precise spatiotemporal correlates of memory formation in the developing brain are not known. We provide rare intracranial evidence that the spatiotemporal propagation of frontal activity supports memory formation in children. Seventeen subjects (6.2 to 19.4 years) studied visual scenes in preparation for a recognition memory test while undergoing direct cortical monitoring. Earlier PFC activity predicted greater accuracy, and subsecond deviations in activity flow between subregions predicted memory formation. Activity flow between inferior and precentral sites was refined during adolescence, partially explaining gains in memory. In contrast, middle frontal activity predicted memory independent of age. These findings show with subsecond temporal precision that the developing PFC links scene perception and memory formation and underscore the role of the PFC in supporting memory development.

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Phase relations of theta oscillations in a computer model of the hippocampal CA1 field: Key role of Schaffer collaterals

Neural Networks ◽

10.1016/j.neunet.2019.04.004 ◽

2019 ◽

Vol 116 ◽

pp. 119-138

Author(s):

Ivan E. Mysin ◽

Valentina F. Kitchigina ◽

Yakov B. Kazanovich

Keyword(s):

Computer Model ◽

Phase Relations ◽

Theta Oscillations ◽

Schaffer Collaterals ◽

Hippocampal Ca1 ◽

Hippocampal Ca1 Field

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Title Role of CPEB3 ribozyme in memory formation

10.26226/morressier.5ebd45acffea6f735881b11f ◽

2020 ◽

Author(s):

Claire Chen

Keyword(s):

Memory Formation

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Role of MicroRNA Genes miR-1000 and miR-375 in Forming Olfactory Conditional Memory in Drosophila melanogaster

MicroRNA ◽

10.2174/2211536609666200204113403 ◽

2020 ◽

Vol 09 ◽

Author(s):

Sadniman Rahman ◽

Chaity Modak ◽

Mousumi Akter ◽

Mohammad Shamimul Alam

Keyword(s):

Learning And Memory ◽

Short Term Memory ◽

Memory Loss ◽

Memory Formation ◽

Neural Integration ◽

Significant Difference ◽

Locomotion Speed ◽

Microrna Genes ◽

With Memory

Background: Learning and memory is basic aspects in neurogenetics as most of the neurological disorders start with dementia or memory loss. Several genes associated with memory formation have been discovered. MicroRNA genes miR-1000 and miR-375 were reported to be associated with neural integration and glucose homeostasis in some insects and vertebrates. However, neuronal function of these genes is yet to be established in D. melanogaster. Objective: Possible role of miR-1000 and miR-375 in learning and memory formation in this fly has been explored in the present study. Methods: Both appetitive and aversive olfactory conditional learning were tested in the miR-1000 and miR-375 knockout (KO) strains and compared with wild one. Five days old third instar larvae were trained by allowing them to be associated with an odor with reward (fructose) or punishment (salt). Then, the larvae were tested to calculate their preferences to the odor trained with. Learning index (LI) values and larval locomotion speed were calculated for all strains. Results: No significant difference was observed for larval locomotion speed in mutant strains. Knockout strain of miR-1000 showed significant deficiency in both appetitive and aversive memory formation whereas miR-375 KO strain showed a significantly lower response only in appetitive one. Conclusion: The results of the present study indicate important role played by these two genes in forming short-term memory in D. melanogaster.

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