scholarly journals Clinical guideline on topical growth factors for skin wounds

2020 ◽  
Vol 8 ◽  
Author(s):  
Chun-mao Han ◽  
Biao Cheng ◽  
Pan Wu ◽  

Abstract An increased number of patients with skin wounds have been witnessed in the past decades. Among the various kinds of treatments for skin wounds, topical exogenous growth factors are indispensable and have been used in many countries. However, whether they have reliable effects remains controversial, and their application for skin wound treatment needs to be further standardized and optimized in terms of socio-economic considerations. Thus, the Chinese Burn Association developed this guideline indicating efficacy, application details, adverse reactions and precautions of five clinically common topical growth factors using the Grading of Recommendations Assessment Development and Evaluation method to promote the rational application of topical exogenous growth factors in skin wounds and to benefit more patients.

2018 ◽  
Vol 44 (11) ◽  
pp. 1671-1676 ◽  
Author(s):  
Cibele Pelissari ◽  
Adriana F.C. Paris ◽  
Andrea Mantesso ◽  
Marília Trierveiler

2016 ◽  
Vol 4 (12) ◽  
pp. 1761-1772 ◽  
Author(s):  
Yeji Kim ◽  
Julie C. Liu

Protein-based microenvironments are promising tools to obtain endothelial cells since they promote hMSC differentiation without exogenous VEGF.


1986 ◽  
Vol 6 (3) ◽  
pp. 870-877 ◽  
Author(s):  
D F Stern ◽  
A B Roberts ◽  
N S Roche ◽  
M B Sporn ◽  
R A Weinberg

To identify functional relationships between oncogenes and growth factors, we compared the effects of transfected myc and ras oncogenes on the responsiveness of Fischer rat 3T3 cells to three growth factors: epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and transforming growth factor-beta (TGF-beta). Control cells did not grow in soft agar under any conditions. ras-Transfected cells grew in soft agar under all conditions tested and were insensitive to the stimulatory effects of exogenous growth factors. These cells secreted elevated levels of both EGF-like factors and TGF-beta, suggesting that the lack of responsiveness of these cells to exogenous growth factors arose from autocrine stimulation. myc-Transfected cells displayed conditional anchorage-independent growth: they formed numerous colonies in soft agar in the presence of EGF but relatively few colonies in the presence of PDGF or TGF-beta. Secretion of EGF-like factors and TGF-beta by these cells was not elevated above that of control cells. These results suggest a model for the mechanism of cooperation between myc and ras oncogenes in which ras-like genes induce growth factor production, while myc-like genes increase the responsiveness of cells to these factors.


Biomaterials ◽  
2012 ◽  
Vol 33 (16) ◽  
pp. 4078-4088 ◽  
Author(s):  
Christine Y. Chuang ◽  
Kifah Shahin ◽  
Megan S. Lord ◽  
James Melrose ◽  
Pauline M. Doran ◽  
...  

2015 ◽  
Vol 104 (5) ◽  
pp. 864-879 ◽  
Author(s):  
Seth Tomblyn ◽  
Elizabeth L. Pettit Kneller ◽  
Stephen J. Walker ◽  
Mary D. Ellenburg ◽  
Christine J. Kowalczewski ◽  
...  

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