Bioactivation of 2-nitrofluorene to reactive intermediates that bind covalenty to DNA, RNA and protein in vitro and in vivo in the rat

1990 ◽  
Vol 11 (1) ◽  
pp. 27-32 ◽  
Author(s):  
Frant C.J. Wierckx ◽  
Rinny Wedzinga ◽  
John H.N. Meerman ◽  
Gerard Mulder
Keyword(s):  
Reactive Intermediates

Generation of Reactive Intermediates from 2-Nitrofluorene that Bind Covalently to DNA, RNA and Protein in Vitro and in Vivo in the RAT

Nitroarenes ◽  
1990 ◽  
pp. 219-230 ◽  
Author(s):  
Gerard J. Mulder ◽  
Frank C. J. Wierckx ◽  
Rinny Wedzinga ◽  
John H. N. Meerman
Keyword(s):  
Reactive Intermediates

Photoactivation of 2-nitrofluorene in vitro and in the rat in vivo. UVA-induced formation of reactive intermediates that bind covalently to RNA and protein

1992 ◽  
Vol 13 (10) ◽  
pp. 1759-1762 ◽  
Author(s):  
Frank C.J. Wierckx ◽  
Gerard M.J.Begijersbergen van Henegouwen ◽  
Leon T. Van den Broeke ◽  
Henk de Vries ◽  
John H.N. Meerman ◽  
...  
Keyword(s):  
Reactive Intermediates

scholarly journals Identification and characterization of in silico, in vivo, in vitro, and reactive metabolites of infigratinib using LC-ITMS: bioactivation pathway elucidation and in silico toxicity studies of its metabolites

RSC Advances ◽  
2020 ◽  
Vol 10 (28) ◽  
pp. 16231-16244 ◽  
Author(s):  
Nasser S. Al-Shakliah ◽  
Mohamed W. Attwa ◽  
Adnan A. Kadi ◽  
Haitham AlRabiah
Keyword(s):  
In Silico ◽  
Reactive Intermediates ◽  
Reactive Metabolites ◽  
Laboratory Work ◽  
Iminium Ions ◽  
In Silico Toxicity ◽  
Identification And Characterization

An in silico web designer tool was utilized to guide laboratory work for infigratinib metabolism. Sixteen metabolites of infigratinib and seven reactive intermediates (three iminium ions and four 1,4 benzoquinones) were characterized using LC-ITMS.

Induction and Differentiation of Dental Epithelium in Vivo and in Vitro

1982 ◽  
Vol 40 ◽  
pp. 142-145
Author(s):  
E. J. Kollar
Keyword(s):  
Connective Tissue ◽  
Oral Mucosa ◽  
Basal Lamina ◽  
Functional Derivatives ◽  
Specific Source ◽  
Dental Epithelium ◽  
Connective Tissue Stroma

The differentiation and maintenance of many specialized epithelial structures are dependent on the underlying connective tissue stroma and on an intact basal lamina. These requirements are especially stringent in the development and maintenance of the skin and oral mucosa. The keratinization patterns of thin or thick cornified layers as well as the appearance of specialized functional derivatives such as hair and teeth can be correlated with the specific source of stroma which supports these differentiated expressions.

Ultrastructural Correlations between Clonal Human Tumor Colonies and in Vivo Neoplasms

1982 ◽  
Vol 40 ◽  
pp. 210-211
Author(s):  
M.J. Murphy ◽  
R.R. Price ◽  
J.C. Sloman
Keyword(s):  
Cultured Cells ◽  
Human Tumor ◽  
Cell Type ◽  
Tumor Mass ◽  
Initial Cell ◽  
Cloning Assay ◽  
Human Tumor Cloning ◽  
The Relationship

The in vitro human tumor cloning assay originally described by Salmon and Hamburger has been applied recently to the investigation of differential anti-tumor drug sensitivities over a broad range of human neoplasms. A major problem in the acceptance of this technique has been the question of the relationship between the cultured cells and the original patient tumor, i.e., whether the colonies that develop derive from the neoplasm or from some other cell type within the initial cell population. A study of the ultrastructural morphology of the cultured cells vs. patient tumor has therefore been undertaken to resolve this question. Direct correlation was assured by division of a common tumor mass at surgical resection, one biopsy being fixed for TEM studies, the second being rapidly transported to the laboratory for culture.

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