Identification and characterization of in silico, in vivo, in vitro, and reactive metabolites of infigratinib using LC-ITMS: bioactivation pathway elucidation and in silico toxicity studies of its metabolites
Keyword(s):
An in silico web designer tool was utilized to guide laboratory work for infigratinib metabolism. Sixteen metabolites of infigratinib and seven reactive intermediates (three iminium ions and four 1,4 benzoquinones) were characterized using LC-ITMS.
Keyword(s):
2017 ◽
Vol 214
(12)
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pp. 3519-3530
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2011 ◽
Vol 22
(1)
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pp. 141-152
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2018 ◽
2016 ◽
Vol 2
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pp. 211-218