Real-Time Gas Chromatography/High Resolution Mass Spectrometry and its Application to the Analysis of Physiological Fluids

1974 ◽  
Vol 12 (11) ◽  
pp. 647-655 ◽  
Author(s):  
B. J. Kimble ◽  
R. E. Cox ◽  
R. V. McPherron ◽  
R. W. Olsen ◽  
E. Roitman ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
High Resolution ◽  
Real Time ◽  
High Resolution Mass Spectrometry ◽  
High Resolution Mass ◽  
Resolution Mass

Immunoadsorption to improve gas chromatography/high-resolution mass spectrometry of estradiol-17 beta in plasma.

1983 ◽  
Vol 29 (4) ◽  
pp. 677-680 ◽  
Author(s):  
S J Gaskell ◽  
B G Brownsey
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
High Resolution ◽  
High Resolution Mass Spectrometry ◽  
Trimethylsilyl Ether ◽  
Internal Standard ◽  
Selected Ion Monitoring ◽  
High Resolution Mass ◽  
Precise Quantification ◽  
Resolution Mass

Abstract We describe a new, highly selective procedure for the determination of estradiol-17 beta in plasma. Samples are extracted with a micro-cellulose-coupled antiserum to estradiol-17 beta. Conversion of the extracted steroid to the bis(trimethylsilyl) ether is followed by gas chromatography/high-resolution mass spectrometry with selected ion monitoring. Precise quantification is achieved through the use of [2H3]estradiol-17 beta as internal standard.

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