Tick-borne Pathogens Detected in the Blood of Immunosuppressed Norwegian Patients Living in a Tick-endemic Area

2020 ◽  
Author(s):  
Hanne Quarsten ◽  
Tore Salte ◽  
Åslaug R Lorentzen ◽  
Inger J W Hansen ◽  
Runar Hamre ◽  
...  
Keyword(s):  
Endemic Area ◽  
Immunosuppressive Treatment ◽  
Borrelia Burgdorferi Sensu Lato ◽  
Borrelia Miyamotoi ◽  
Autoimmune Conditions ◽  
Predominant Pathogen ◽  
Immunosuppressed Patients ◽  
Pathogen Dna ◽  
Neoehrlichia Mikurensis ◽  
Babesia Spp

Abstract Background The knowledge regarding the occurrence and the clinical implications of tick-borne infections in immunosuppressed patients living in tick-endemic areas is limited. Methods Adult patients with autoimmune conditions requiring immunosuppressive treatment such as infliximab and rituximab were invited to participate in the study when they attended the hospital for treatment and/or control of the disease. Whole-blood samples were analyzed by real-time polymerase chain reaction for Borrelia burgdorferi sensu lato, Borrelia miyamotoi, Anaplasma phagocytophilum, Rickettsia spp., Candidatus Neoehrlichia mikurensis, and Babesia spp. Results The occurrence of tick-borne pathogens in the blood of patients (n = 163) with autoimmune conditions requiring immunosuppressive treatment was evaluated. Pathogen DNA was detected in 8.6% (14/163) of the patients. The predominant pathogen was Ca. Neoehrlichia mikurensis (12/14), which was carried in the blood of infected patients for 10–59 days until treatment with doxycycline. B. burgdorferi s.l. and Rickettsia spp. were detected in 1 patient each. The B. burgdorferi–infected patient presented with fever, whereas the remaining patients were judged to have subclinical infections. B. miyamotoi, A. phagocytophilum, and Babesia spp. were not detected in any patient. Conclusions Patients treated with biologicals and living in a tick-endemic area seem to have a high risk of contracting Ca. Neoehrlichia mikurensis infection, which, if left untreated, could result in thromboembolic complications.

Borrelia miyamotoiin host-seekingIxodes ricinusticks in England

2014 ◽  
Vol 143 (5) ◽  
pp. 1079-1087 ◽  
Author(s):  
K. M. HANSFORD ◽  
M. FONVILLE ◽  
S. JAHFARI ◽  
H. SPRONG ◽  
J. M. MEDLOCK
Keyword(s):  
Public Health ◽  
Disease Transmission ◽  
Anaplasma Phagocytophilum ◽  
Borrelia Burgdorferi Sensu Lato ◽  
Borrelia Miyamotoi ◽  
Infection Rates ◽  
Public Health Importance ◽  
Widespread Distribution ◽  
Risk Areas ◽  
Neoehrlichia Mikurensis

SUMMARYThis paper reports the first detection ofBorrelia miyamotoiin UKIxodes ricinusticks. It also reports on the presence and infection rates ofI. ricinusfor a number of other tick-borne pathogens of public health importance. Ticks from seven regions in southern England were screened forB. miyamotoi, Borrelia burgdorferi sensu lato(s.l.),Anaplasma phagocytophilumandNeoehrlichia mikurensisusing qPCR. A total of 954I. ricinusticks were tested, 40 were positive forB. burgdorferi s.l., 22 positive forA. phagocytophilumand three positive forB. miyamotoi, with noN. mikurensisdetected. The three positiveB. miyamotoiticks came from three geographically distinct areas, suggesting a widespread distribution, and from two separate years, suggesting some degree of endemicity. Understanding the prevalence ofBorreliaand other tick-borne pathogens in ticks is crucial for locating high-risk areas of disease transmission.

scholarly journals Surveillance of Ticks and Tick-Borne Pathogens in Suburban Natural Habitats of Central Maryland

2021 ◽  
Author(s):  
Matthew T Milholland ◽  
Lars Eisen ◽  
Robyn M Nadolny ◽  
Andrias Hojgaard ◽  
Erika T Machtinger ◽  
...  
Keyword(s):  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
Spotted Fever ◽  
Babesia Microti ◽  
Borrelia Burgdorferi Sensu Lato ◽  
Spotted Fever Group ◽  
Borrelia Miyamotoi ◽  
Natural Habitats ◽  
Questing Ticks ◽  
Tick Vectors

Abstract Lyme and other tick-borne diseases are increasing in the eastern United States and there is a lack of research on integrated strategies to control tick vectors. Here we present results of a study on tick-borne pathogens detected from tick vectors and rodent reservoirs from an ongoing 5-yr tick suppression study in the Lyme disease-endemic state of Maryland, where human-biting tick species, including Ixodes scapularis Say (Acari: Ixodidae) (the primary vector of Lyme disease spirochetes), are abundant. During the 2017 tick season, we collected 207 questing ticks and 602 ticks recovered from 327 mice (Peromyscus spp. (Rodentia: Cricetidae)), together with blood and ear tissue from the mice, at seven suburban parks in Howard County. Ticks were selectively tested for the presence of the causative agents of Lyme disease (Borrelia burgdorferi sensu lato [s.l.]), anaplasmosis (Anaplasma phagocytophilum), babesiosis (Babesia microti), ehrlichiosis (Ehrlichia ewingii, Ehrlichia chaffeensis, and ‘Panola Mountain’ Ehrlichia) and spotted fever group rickettsiosis (Rickettsia spp.). Peromyscus ear tissue and blood samples were tested for Bo. burgdorferi sensu stricto (s.s), A. phagocytophilum, Ba. microti, and Borrelia miyamotoi. We found 13.6% (15/110) of questing I. scapularis nymphs to be Bo. burgdorferi s.l. positive and 1.8% (2/110) were A. phagocytophilum positive among all sites. Borrelia burgdorferi s.s. was found in 71.1% (54/76) of I. scapularis nymphs removed from mice and 58.8% (194/330) of captured mice. Results from study on tick abundance and pathogen infection status in questing ticks, rodent reservoirs, and ticks feeding on Peromyscus spp. will aid efficacy evaluation of the integrated tick management measures being implemented.

scholarly journals Monitoring of Nesting Songbirds Detects Established Population of Blacklegged Ticks and Associated Lyme Disease Endemic Area in Canada

Healthcare ◽  
2020 ◽  
Vol 8 (1) ◽  
pp. 59 ◽  
Author(s):  
John D. Scott ◽  
Emily L. Pascoe ◽  
Muhammad S. Sajid ◽  
Janet E. Foley
Keyword(s):  
Lyme Disease ◽  
Endemic Area ◽  
Ixodes Scapularis ◽  
Borrelia Burgdorferi Sensu Lato ◽  
Blacklegged Tick ◽  
Local Residents ◽  
Novel Method ◽  
Flab Gene ◽  
Local Healthcare ◽  
Established Population

This study provides a novel method of documenting established populations of bird-feeding ticks. Single populations of the blacklegged tick, Ixodes scapularis, and the rabbit tick, Haemaphysalis leporispalustris, were revealed in southwestern Québec, Canada. Blacklegged tick nymphs and, similarly, larval and nymphal rabbit ticks were tested for the Lyme disease bacterium, Borrelia burgdorferi sensu lato (Bbsl), using PCR and the flagellin (flaB) gene, and 14 (42%) of 33 of blacklegged tick nymphs tested were positive. In contrast, larval and nymphal H. leporsipalustris ticks were negative for Bbsl. The occurrence of Bbsl in I. scapularis nymphs brings to light the presence of a Lyme disease endemic area at this songbird nesting locality. Because our findings denote that this area is a Lyme disease endemic area, and I. scapularis is a human-biting tick, local residents and outdoor workers must take preventive measures to avoid tick bites. Furthermore, local healthcare practitioners must include Lyme disease in their differential diagnosis.

scholarly journals Detection of Borrelia burgdorferi Sensu Lato and Relapsing Fever Borrelia in Feeding Ixodes Ticks and Rodents in Sarawak, Malaysia: New Geographical Records of Borrelia yangtzensis and Borrelia miyamotoi

Pathogens ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 846
Author(s):  
Alice C. C. Lau ◽  
Yongjin Qiu ◽  
Mohamed Abdallah Mohamed Moustafa ◽  
Ryo Nakao ◽  
Michito Shimozuru ◽  
...  
Keyword(s):  
Borrelia Burgdorferi ◽  
Borrelia Burgdorferi Sensu Lato ◽  
Primary Forest ◽  
Borrelia Miyamotoi ◽  
Relapsing Fever ◽  
Ixodes Ticks ◽  
Ixodes Granulatus ◽  
New Geographical Record ◽  
Etiological Agents ◽  
Malaysian Borneo

Members of the Borrelia burgdorferi sensu lato (Bbsl) complex are etiological agents of Lyme disease (LD), and Borrelia miyamotoi is one of the relapsing fever Borrelia (RFB). Despite the serological evidence of LD in Malaysia, there has been no report from Sarawak, Malaysian Borneo. Thus, this study aimed to detect and characterize Borrelia in rodents and Ixodes ticks from primary forests and an oil palm (OP) plantation in Sarawak. Borrelia yangtzensis (a member of the Bbsl complex) was detected in 43.8% (14/32) of Ixodes granulatus; most of the positive ticks were from the OP plantation (13/14). Out of 56 rodents, B. yangtzensis was detected in four Rattus spp. from the OP plantation and B. miyamotoi was detected in one rodent, Sundamys muelleri, from the primary forest. Further, the positive samples of B. yangtzensis were randomly selected for multilocus sequence analysis (MLSA). The MLSA results of successfully amplified tick samples revealed a clustering with the sequences isolated from Japan and China. This study is the first evidence of B. miyamotoi, a known human pathogen in Malaysia, and B. yangtzensis, which is circulating in ticks and rodents in Sarawak, Malaysian Borneo, and presenting a new geographical record of the Borrelia spp.

scholarly journals Questing Ixodes ricinus ticks (Acari, Ixodidae) as a vector of Borrelia burgdorferi sensu lato and Borrelia miyamotoi in an urban area of north-eastern Poland

2019 ◽  
Vol 78 (1) ◽  
pp. 113-126 ◽  
Author(s):  
Katarzyna Kubiak ◽  
Janina Dziekońska-Rynko ◽  
Hanna Szymańska ◽  
Dariusz Kubiak ◽  
Małgorzata Dmitryjuk ◽  
...  
Keyword(s):  
Borrelia Burgdorferi ◽  
Urban Area ◽  
Ixodes Ricinus ◽  
Borrelia Burgdorferi Sensu Lato ◽  
Borrelia Miyamotoi ◽  
North Eastern ◽  
Ixodes Ricinus Ticks

Neues zu zeckenübertragenen Infektionen

2017 ◽  
Vol 142 (11) ◽  
pp. 805-810
Author(s):  
Johannes Borde ◽  
Gerhard Dobler ◽  
Siegbert Rieg
Keyword(s):  
Borrelia Burgdorferi ◽  
Francisella Tularensis ◽  
Borrelia Burgdorferi Sensu Lato ◽  
Borrelia Miyamotoi ◽  
Emerging Pathogen

Was ist neu? Frühsommer-Meningoenzephalitis (FSME) In Europa nimmt die Ausbreitung von FSME in Richtung Westen zu. Erstmalig ist 2016 ein autochthoner humaner FSME-Fall in den Niederlanden dokumentiert worden. Die FSME-Erkrankungsfälle im Landkreis Reutlingen rücken die alimentäre FSME-Transmission in Deutschland wieder in das Bewusstsein. Tularämie (Hasenpest) Francisella tularensis hat ein breites Wirtsspektrum, von Kleinsäugern bis hin zu Arthropoden, wie z. B. Schildzecken. Die Transmission durch Zeqcken wurde bisher wenig beachtet. Vor dem Hintergrund neuerer epidemiologischen Erkenntnisse sollte auch nach Zeckenstichen mit entsprechenden Symptomen eine Francisella tularensis Infektion in Erwägung gezogen werden. Persistierende Beschwerden bei Borreliose (Borrelia-burgdorferi-sensu-lato-Komplex) Eine aktuelle Studie untersuchte den Effekt einer verlängerten antiinfektiven Behandlungsdauer auf persistierende Symptome, die mit einer Borrelieninfektion (Borrelia-burgdorferi-sensu-lato-Komplex) in Verbindung gebracht werden können. Die Therapie über 2 Wochen führte zu einer quantitativ gleichen und ebenso nachhaltigen Zunahme der Lebensqualität wie ein verlängertes Schema. Borrelia miyamotoi ist ein „Emerging Pathogen“ – erstmalig konnte nun auch in Deutschland ein humaner Infektionsfall nachgewiesen werden.

scholarly journals Pediatric Immunization Practices in Nephrotic Syndrome: An Assessment of Provider and Parental Knowledge

2021 ◽  
Vol 8 ◽  
Author(s):  
Cheryl L. Tran ◽  
David T. Selewski ◽  
Gia J. Oh ◽  
Jonathan P. Troost ◽  
Susan F. Massengill ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Pediatric Patients ◽  
Immunosuppressive Treatment ◽  
Parental Knowledge ◽  
Concurrent Treatment ◽  
Live Vaccines ◽  
Immunosuppressive Medications ◽  
Immunosuppressed Patients ◽  
Immunological Effects ◽  
Medical Subspecialty

Background: Children with nephrotic syndrome (NS) are at high risk for vaccine-preventable infections due to the immunological effects from the disease and concurrent treatment with immunosuppressive medications. Immunizations in these patients may be deferred due to their immunosuppressive treatment which may increase the risk for vaccine-preventable infections. Immunization practices in children with NS continue to vary among pediatric nephrologists. This raises the question of whether children with NS are receiving the recommended vaccinations at appropriate times. Therefore, it is critical to understand the practices and patient education provided by physicians to patients on the topic of vaccinations.Methods: After informed consent, parents/guardians of 153 pediatric patients (<18 years old) diagnosed with NS from 2005 to 2018 and 50 pediatric nephrologists from 11 participating centers completed anonymous surveys to evaluate immunization practices among pediatric nephrologists, assess the vaccine education provided to families of children with NS, assess the parental knowledge of immunization recommendations, and assess predictors of polysaccharide pneumococcal vaccine adherence. The Advisory Committee on Immunization Practices (ACIP) Immunization 2019 Guideline for those with altered immunocompetence was used to determine accuracy of vaccine knowledge and practices.Results: Forty-four percent of providers self-reported adherence to the ACIP guidelines for inactive vaccines and 22% to the guidelines for live vaccines. Thirty-two percent of parents/guardians reported knowledge that aligned with the ACIP guidelines for inactive vaccines and 1% for live vaccines. Subjects residing in the Midwest and provider recommendations for vaccines were positive predictors of vaccine adherence (p < 0.001 and p 0.02, respectively).Conclusions: Vaccine recommendation by medical providers is paramount in vaccine adherence among pediatric patients with NS. This study identifies potential educational opportunities for medical subspecialty providers and family caregivers about immunization recommendations for immunosuppressed patients.

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