Evaluation of a New Radioimmunoassay Method for Carcinoembryonic Antigen in Plasma, with Use of Zirconyl Phosphate Gel

1972 ◽  
Vol 18 (9) ◽  
pp. 918-922 ◽  
Author(s):  
Tsann Ming Chu ◽  
Gustavo Reynoso
Keyword(s):  
Quality Control ◽  
Carcinoembryonic Antigen ◽  
Clinical Laboratory ◽  
Statistical Quality Control ◽  
Control Procedure ◽  
Statistical Quality ◽  
Quality Control Procedure ◽  
Highly Sensitive ◽  
Radioimmunoassay Method

Abstract A radioimmunoassay of carcinoembryonic antigen in plasma is described and evaluated. The assay can be easily performed and implemented in a clinical laboratory. Assessed by Rodbard’s statistical quality-control procedure, the assay is shown to be highly sensitive, precise, and reproducible.

Reference-mean-centered statistical quality control

2020 ◽  
Vol 58 (9) ◽  
pp. 1517-1523
Author(s):  
Martín Yago ◽  
Carolina Pla
Keyword(s):  
Quality Control ◽  
Measurement Procedure ◽  
Statistical Quality Control ◽  
Measuring Instruments ◽  
Control Procedure ◽  
Control Material ◽  
Statistical Quality ◽  
Maximum Benefit ◽  
Control Procedures

AbstractBackgroundStatistical quality control (SQC) procedures generally use rejection limits centered on the stable mean of the results obtained for a control material by the analyzing instrument. However, for instruments with significant bias, re-centering the limits on a different value could improve the control procedures from the viewpoint of patient safety.MethodsA statistical model was used to assess the effect of shifting the rejection limits of the control procedure relative to the instrument mean on the number of erroneous results reported as a result of an increase in the systematic error of the measurement procedure due to an out-of-control condition. The behaviors of control procedures of type 1ks (k = 2, 2.5, 3) were studied when applied to analytical processes with different capabilities (σ = 3, 4, 6).ResultsFor measuring instruments with bias, shifting the rejection limits in the direction opposite to the bias improves the ability of the quality control procedure to limit the risk posed to patients in a systematic out-of-control condition. The maximum benefit is obtained when the displacement is equal to the bias of the instrument, that is, when the rejection limits are centered on the reference mean of the control material. The strategy is sensitive to error in estimating the bias. Shifting the limits more than the instrument’s bias disproportionately increases the risk to patients. This effect should be considered in SQC planning for systems running the same test on multiple instruments.ConclusionsCentering the control rule on the reference mean is a potentially useful strategy for SQC planning based on risk management for measuring instruments with significant and stable uncorrected bias. Low uncertainty in estimating bias is necessary for this approach not to be counterproductive.

Practice of patient based quality assessment procedure in clinical chemistry unit at diagnostic laboratories in Nepal

2013 ◽  
Vol 1 (1) ◽  
pp. 9-17
Author(s):  
P Gyawali ◽  
S Tamrakar ◽  
N Lamsal ◽  
RK Shresta
Keyword(s):  
Quality Control ◽  
Clinical Laboratory ◽  
Clinical Chemistry ◽  
Vital Role ◽  
Control Procedure ◽  
Assessment Procedure ◽  
Random Errors ◽  
Quality Control Procedure ◽  
Total Testing Process ◽  
Analytical Errors

Background: The clinical laboratory is the major producer of information used to diagnose, treat, and monitor patients. Errors in laboratory testing may occur at many different points in the total testing process (TTP). Application of quality control plays a vital role in recognizing probable errors. The current dominant technique for error identification uses quality control materials has several inherent drawbacks; otherwise, patient based quality control procedure ensures the detection of pre-analytical errors, analytical, post-analytical errors, clerical errors, and random errors that cannot be detected using commonly used quality control methods, thereby improving the reliability of clinical tests. Objective: Thus the objective of this study was to evaluate the practice of patient based quality control procedure in clinical chemistry unit at diagnostic laboratories in Nepal. Materials and Methods: The questionnaire based study was conducted in clinical chemistry unit of diagnostic laboratories across the country. Questionnaires were personally dropped in 217 clinical biochemistry laboratories and were asked to complete a practice based questionnaire. The responses of 169 laboratories were analyzed using Microsoft Excel 2007 and expressed in terms of percentage. Results: In foremost study undertaken, a total of 169 laboratories responded to the questionnaire. A total 65.9 % of the laboratories monitored errors using patient based quality control procedure but not as a part of quality control. Very few of participant.s laboratories responded accurately regarding utility and practical aspects of patient based quality control included in the checklist. Conclusion: Practice of patient based quality control procedure was not well established to identify possible errors. Hence, the study extent the existing information and explored that the current classical approaches were not adequate to assure accurate patients test results for specific analytes. DOI: http://dx.doi.org/10.3126/stcj.v1i1.7983 Sunsari Technical College Journal Vol.1(1) 2012 9-17

Statistical Quality Control of HIV-1 ELISA Test Performance

1994 ◽  
Vol 89 (428) ◽  
pp. 1200-1208 ◽  
Author(s):  
R. C. Gentleman ◽  
M. S. Hamada ◽  
D. E. Matthews ◽  
A. R. Wilson
Keyword(s):  
Quality Control ◽  
Test Performance ◽  
Elisa Test ◽  
Statistical Quality Control ◽  
Statistical Quality ◽  
Hiv 1

Inspection Efficiency

1945 ◽  
Vol 152 (1) ◽  
pp. 69-75
Author(s):  
J. C. Edwards ◽  
W. A. Bennett
Keyword(s):  
Quality Control ◽  
Personnel Selection ◽  
Statistical Quality Control ◽  
Statistical Quality ◽  
Time And Motion Study ◽  
Time And Motion ◽  
Motion Study

The purpose of the paper is to outline the numerous directions in which improvements can be sought in engineering inspection. It shows how direct improvements in efficiency can be effected by carefully planned methods of recording results, including the use of statistical quality control, by adopting the principles of time and motion study in the planning of flow of work through inspection, and in the design of gauging fixtures and the arrangement of gauges. The importance of correct personnel selection and organization is stressed, as is also the avoidance of duplication of inspection. The paper concludes by quoting figures showing the substantial reductions which have been achieved in the authors' company by a progressive application of the methods described over a period of several years.

Statistical Quality Control Using Excel

Technometrics ◽  
2000 ◽  
Vol 42 (2) ◽  
pp. 221
Author(s):  
Eric R. Ziegel ◽  
Steven M. Zimmerman ◽  
Marjorie L. Icenogle
Keyword(s):  
Quality Control ◽  
Statistical Quality Control ◽  
Statistical Quality
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