Design of quality-control specimens for use with a small multi-channel analyzer.

1977 ◽  
Vol 23 (11) ◽  
pp. 2011-2023 ◽  
Author(s):  
T E Caragher ◽  
G F Grannis
Keyword(s):  
Quality Control ◽  
Performance Evaluation ◽  
Linear Relationships ◽  
Instrument Response ◽  
Individual Specimen ◽  
Channel Analyzer

Abstract Specimens having linear relationships between concentration and instrument response for seven analytes were prepared for use with a small multi-channel analyzer. The specimens had inter-specimen and inter-constituent relationships that facilitated the performance evaluation of all channels simultaneously with each individual specimen. Techniques are described for use of the specimens in various aspects of quality control.

Performance Evaluation and Planning for Patient-Based Quality Control Procedures

2000 ◽  
Vol 113 (2) ◽  
pp. 240-248 ◽  
Author(s):  
Jay J. Ye ◽  
Stephen C. Ingels ◽  
Curtis A. Parvin
Keyword(s):  
Quality Control ◽  
Performance Evaluation ◽  
Control Procedures

scholarly journals Book Reviews

2016 ◽  
Vol 28 (4) ◽  
Author(s):  
Walter Böhm ◽  
Wilfried Grossmann ◽  
Reinhard Viertl ◽  
Friedrich Leisch ◽  
Klaus Pötzelberger ◽  
...  
Keyword(s):  
Quality Control ◽  
Random Number ◽  
Control Strategies ◽  
Random Number Generation ◽  
Statistical Quality Control ◽  
Continual Improvement ◽  
Linear Relationships ◽  
History Of ◽  
Cumulative Sum Charts

Fitting Linear Relationships: A History of the Calculus of Observations 1750-1900.(R.W. Farebrother)Basic Business Statistic. (D.P. Foster, R.A. Stine, R.P. Waterman)Statistische und numerische Methoden der Datenanalyse. (V. Blobel, E. Lohrmann)The Practice of Time Series Analysis. (H. Akaike, G. Kitagawa)Finanzmathematik. Die Bewertung von Derivaten (A. Irle)Programming with Data. A Guide to the S Language (J.M. Chambers)Random Number Generation and Monte Carlo Methods. (J.E. Gentle)Wirtschafts- und Sozialwissenschaftliche Panel-Studien, Daten-Strukturen und Analyse-Verfahren. (R. Hujer, U. Rendtel, G. Wagner)Cumulative Sum Charts and Charting for Quality Improvement. (D.M. Hawkins,D.H. Olwell)Statistical Quality Control. Strategies and Tools for Continual Improvement. (J.Ledolter, C.W. Burrill)

Validated Chromatographic Methods for Simultaneous Estimation of Cinnarizine in Binary Mixture with Domperidone and Paracetamol in Tablets

2019 ◽  
Vol 15 (5) ◽  
pp. 429-438
Author(s):  
Marianne Alphonse Mahrouse ◽  
Asmaa Ahmed El-Zaher ◽  
Ahmed Mohammed Al-Ghani
Keyword(s):  
Quality Control ◽  
Hplc Method ◽  
Simultaneous Estimation ◽  
Chromatographic Methods ◽  
Treatment And Prevention ◽  
Rp Hplc ◽  
Linear Relationships ◽  
Ich Guidelines ◽  
Analytical Tools

Background:Cinnarizine, an antihistaminic drug, is commonly formulated in combination with domperidone and with paracetamol for treatment and prevention of motion sickness and migraine.Objective:The aim of this work was to develop new, simple, precise and selective chromatographic methods (RP-HPLC and TLC-densitometric methods) for the determination of these drugs. These methods can be used as analytical tools in the routine examination in quality control laboratories.Methods:The first method was RP-HPLC method, the separation was carried out on an Inertsil® ODS- 3V C18 column (250 mm × 4.6 mm, 5 µm) using a mobile phase composed of methanol: acetonitrile (45: 55, v/v) at a flow rate of 1 ml/min. The detection was carried out at 220 nm. The second method was a TLC-densitometric method where the studied components were separated using a developing system composed of toluene: ethyl acetate: methanol: triethylamine (5: 4.3: 0.7: 0.5, v/v/v/v) on TLC silica gel 60 F254 plates, followed by densitometric scanning at 270 nm.Results:In RP-HPLC method, the peaks were sharp and well separated, the retention times were 5.25, 3.48 and 2.78 min, for cinnarizine, domperidone and paracetamol, respectively. Linearity was obtained over the concentration ranges 1-22, 0.75-16.5 and 25-550 µg/ml, for cinnarizine, domperidone and paracetamol, respectively. In TLC-densitometric method, good separation of spots and linear relationships were achieved over the concentration ranges of 0.2-2, 0.15-1.5 and 5-50 µg/spot, for cinnarizine, domperidone and paracetamol, respectively. Method validation was conducted according to ICH guidelines in terms of linearity, accuracy, selectivity, precision and robustness.Conclusion:The developed methods were applied for the determination of the cited drugs in tablets containing binary drug mixtures. The methods are simple and precise and can be used for routine analysis of the labelled drugs in combined dosage forms in quality control laboratories.

Performance Evaluation and Quality Control of Polygraphs for Cardiac Catheterization

1998 ◽  
Vol 54 (4) ◽  
pp. 512-516
Author(s):  
KOICHI CHIDA ◽  
TATSUO NGASAKA ◽  
MASAHIRO SAI ◽  
HIROKI ISHIYA ◽  
KUNIHIKO SATO ◽  
...  
Keyword(s):  
Quality Control ◽  
Performance Evaluation ◽  
Cardiac Catheterization
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