Clinical utility of cyclosporine concentrations determined in recipients of small-bowel transplant by HPLC and fluorescence polarization immunoassay

1991 ◽  
Vol 37 (2) ◽  
pp. 291-291
Author(s):  
N Sadeg ◽  
C Pham Huy ◽  
M Postaire ◽  
J R Claude ◽  
M Hamon
Keyword(s):  
Small Bowel ◽  
Fluorescence Polarization ◽  
Clinical Utility ◽  
Fluorescence Polarization Immunoassay ◽  
Small Bowel Transplant

Cyclosporine concentrations in blood after liver transplantation: correlation of immunoassay results with clinical events.

1989 ◽  
Vol 35 (4) ◽  
pp. 564-568 ◽  
Author(s):  
M C Haven ◽  
L M Sobeski ◽  
R A Earl ◽  
R S Markin
Keyword(s):  
Liver Transplantation ◽  
Whole Blood ◽  
Clinical Condition ◽  
Fluorescence Polarization ◽  
Clinical Utility ◽  
Correlation Coefficients ◽  
Fluorescence Polarization Immunoassay ◽  
Excretory Function ◽  
Clinical Events ◽  
Concentration Result

Abstract To investigate the clinical utility of immunoassays for cyclosporine and metabolites in plasma and whole blood, we monitored 25 patients after orthotopic liver transplantation. We compared cyclosporine as measured by TDx fluorescence polarization immunoassay (of both plasma and whole blood) and by two polyclonal radioimmunoassays (from Sandoz and INCSTAR). We found considerable differences in measured cyclosporine concentrations, which were dependent on method, matrix, and clinical condition. Correlation coefficients between results by the various methods for samples from individual patients ranged from 0.825 to 0.996. The three methods used for monitoring cyclosporine in whole blood gave proportional results (Sandoz less than INCSTAR less than TDx) in individual patients, but results for the two methods for plasma sometimes differed by more than 100%. In some cases, ratios of plasma cyclosporine concentration (result by TDx/result by Sandoz) were correlated with disturbances in hepatic excretory function or kidney function. This ratio may be useful in monitoring for nephrotoxicity.

Long-Term Endoscopic Follow-up in Small Bowel Transplant Recipients: Single-Center Series

2014 ◽  
Vol 46 (7) ◽  
pp. 2325-2328 ◽  
Author(s):  
A. Lauro ◽  
A.D. Pinna ◽  
S. Pellegrini ◽  
A. Bagni ◽  
C. Zanfi ◽  
...  
Keyword(s):  
Small Bowel ◽  
Transplant Recipients ◽  
Single Center ◽  
Small Bowel Transplant

scholarly journals A Modified Fluorescence Polarization Immunoassay Method Incorporating Fat Emulsion(FE-FPIA) to Determine Cyclosporin A Concentrations in Rat Skin.

1999 ◽  
Vol 22 (5) ◽  
pp. 539-542
Author(s):  
Yuji KUROSAKI ◽  
Tomoya ASADA ◽  
Nanae YASUMOTO ◽  
Toshiaki NAKAMURA ◽  
Mikio MASADA ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Fluorescence Polarization ◽  
Fluorescence Polarization Immunoassay ◽  
Rat Skin ◽  
Fat Emulsion
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