Kinetics of onset of rate-dependent effects of Class I antiarrhythmic drugs are important in determining their effects on refractoriness in guinea-pig ventricle, and provide a theoretical basis for their subclassification

T. J CAMPBELL

doi:10.1093/cvr/17.6.344

Kinetics of onset of rate-dependent effects of Class I antiarrhythmic drugs are important in determining their effects on refractoriness in guinea-pig ventricle, and provide a theoretical basis for their subclassification

Cardiovascular Research ◽

10.1093/cvr/17.6.344 ◽

1983 ◽

Vol 17 (6) ◽

pp. 344-352 ◽

Cited By ~ 223

Author(s):

T. J CAMPBELL

Keyword(s):

Guinea Pig ◽

Theoretical Basis ◽

Antiarrhythmic Drugs ◽

Class I ◽

Rate Dependent ◽

Kinetics Of

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Kinetics of onset of rate-dependent effects of Class I antiarrhythmic drugs are important in determining their effects on refractoriness in guinea-pig ventricle, and provide a theoretical basis for their subclassification

Cardiovascular Research ◽

10.1016/s0008-6363(99)00308-9 ◽

2000 ◽

Vol 45 (1) ◽

pp. 55-56

Author(s):

T Campbell

Keyword(s):

Guinea Pig ◽

Theoretical Basis ◽

Antiarrhythmic Drugs ◽

Class I ◽

Rate Dependent ◽

Kinetics Of

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Importance of physico-chemical properties in determining the kinetics of the effects of Class I antiarrhythmic drugs on maximum rate of depolarization in guinea-pig ventricle

British Journal of Pharmacology ◽

10.1111/j.1476-5381.1983.tb11046.x ◽

1983 ◽

Vol 80 (1) ◽

pp. 33-40 ◽

Cited By ~ 66

Author(s):

Terence J. Campbell

Keyword(s):

Guinea Pig ◽

Maximum Rate ◽

Antiarrhythmic Drugs ◽

Chemical Properties ◽

Class I ◽

Physico Chemical ◽

Kinetics Of

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Estimation of depressant effects of class I antiarrhythmic drugs on intraventricular conduction : Rate-dependent effects on QRS duration : Assessment of clinical efficacy of antiarrhthmic drugs

Japanese Circulation Journal ◽

10.1253/jcj.56.supplementv_1477 ◽

1993 ◽

Vol 56 (SupplementV) ◽

pp. 1477-1479

Author(s):

Nobuo Ikeda ◽

Kaichiro Kamiya

Keyword(s):

Clinical Efficacy ◽

Antiarrhythmic Drugs ◽

Class I ◽

Intraventricular Conduction ◽

Rate Dependent ◽

Qrs Duration

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Inhibitory effects of class I and IV antiarrhythmic drugs on the Na+-activated K+ channel current in guinea pig ventricular cells

Naunyn-Schmiedeberg s Archives of Pharmacology ◽

10.1007/pl00005306 ◽

1998 ◽

Vol 358 (6) ◽

pp. 641-648 ◽

Cited By ~ 14

Author(s):

Katsumi Mori ◽

Satoru Kobayashi ◽

Toshihiro Saito ◽

Yoshiaki Masuda ◽

H. Nakaya

Keyword(s):

Guinea Pig ◽

Antiarrhythmic Drugs ◽

Class I ◽

K Channel ◽

Inhibitory Effects ◽

Channel Current ◽

Ventricular Cells

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A model study of use-dependent effects of class I antiarrhythmic drugs in guinea-pig papillary muscles as related to external potassium concentration

The Japanese Journal of Pharmacology ◽

10.1016/s0021-5198(19)50050-6 ◽

1994 ◽

Vol 64 ◽

pp. 102

Author(s):

T. Hamamoto ◽

M. Kojima ◽

M. Matsuzaki ◽

R. Kusukawa ◽

T. Ban

Keyword(s):

Guinea Pig ◽

Antiarrhythmic Drugs ◽

Potassium Concentration ◽

Class I ◽

Papillary Muscles ◽

Model Study ◽

External Potassium

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Effects of class I antiarrhythmic drugs on mitochondrial ATPase activity in guinea pig heart preparations

General Pharmacology The Vascular System ◽

10.1016/0306-3623(93)90040-5 ◽

1993 ◽

Vol 24 (1) ◽

pp. 233-237 ◽

Cited By ~ 5

Author(s):

Abdulrahman A. Almotrefi

Keyword(s):

Guinea Pig ◽

Atpase Activity ◽

Antiarrhythmic Drugs ◽

Class I ◽

Mitochondrial Atpase ◽

Guinea Pig Heart ◽

Mitochondrial Atpase Activity

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Block of activated and inactivated sodium channels by class-I antiarrhythmic drugs studied by using the maximum upstroke velocity (V̇max) of action potential in guinea-pig cardiac muscles

Journal of Molecular and Cellular Cardiology ◽

10.1016/s0022-2828(87)80582-5 ◽

1987 ◽

Vol 19 (4) ◽

pp. 367-377 ◽

Cited By ~ 54

Author(s):

I KODAMA ◽

J TOYAMA ◽

C TAKANAKA ◽

K YAMADA

Keyword(s):

Guinea Pig ◽

Action Potential ◽

Sodium Channels ◽

Antiarrhythmic Drugs ◽

Class I ◽

Cardiac Muscles ◽

Upstroke Velocity

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Class I antiarrhythmic drugs alter the severity of myocardial stunning by modulating ATP-sensitive K+ channels in guinea pig ventricular muscles

Naunyn-Schmiedeberg s Archives of Pharmacology ◽

10.1007/pl00005169 ◽

1998 ◽

Vol 357 (3) ◽

pp. 283-290 ◽

Cited By ~ 3

Author(s):

S. Shigematsu ◽

T. Sato ◽

M. Arita

Keyword(s):

Guinea Pig ◽

Myocardial Stunning ◽

Antiarrhythmic Drugs ◽

Class I ◽

K Channels

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Blockade of 2,4-dinitrophenol induced ATP sensitive potassium current in guinea pig ventricular myocytes by class I antiarrhythmic drugs

Cardiovascular Research ◽

10.1093/cvr/26.11.1095 ◽

1992 ◽

Vol 26 (11) ◽

pp. 1095-1101 ◽

Cited By ~ 29

Author(s):

B. Wu ◽

T. Sato ◽

T. Kiyosue ◽

M. Arita

Keyword(s):

Guinea Pig ◽

Potassium Current ◽

Antiarrhythmic Drugs ◽

Ventricular Myocytes ◽

Class I

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Relationship between negative inotropic and chronotropic effects of tocainide and five class I antiarrhythmic drugs in the coronary perfused guinea-pig heart

General Pharmacology The Vascular System ◽

10.1016/0306-3623(93)90217-l ◽

1993 ◽

Vol 24 (3) ◽

pp. 599-604 ◽

Cited By ~ 2

Author(s):

Tatsuhiko Matsumoto ◽

Junichi Hasegawa ◽

Hiroto Mashiba

Keyword(s):

Guinea Pig ◽

Antiarrhythmic Drugs ◽

Class I ◽

Guinea Pig Heart ◽

Chronotropic Effects

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