Effects of potassium channel modulation during global ischaemia in isolated rat heart with and without cardioplegia

1992 ◽  
Vol 26 (11) ◽  
pp. 1063-1068 ◽  
Author(s):  
M. Galinanes ◽  
M. J Shattock ◽  
D. J Hearse
Keyword(s):  
Potassium Channel ◽  
Rat Heart ◽  
Isolated Rat Heart ◽  
Channel Modulation ◽  
Global Ischaemia ◽  
Isolated Rat

ATP-sensitive potassium channels regulate stimulated ANF secretion in isolated rat heart

1996 ◽  
Vol 271 (6) ◽  
pp. H2339-H2345 ◽  
Author(s):  
T. Xu ◽  
J. H. Jiao ◽  
R. A. Pence ◽  
A. J. Baertschi
Keyword(s):  
Potassium Channels ◽  
Potassium Channel ◽  
Rat Heart ◽  
Atrial Natriuretic Factor ◽  
Left Atrial ◽  
Channel Blocker ◽  
Acute Hypoxia ◽  
Isolated Rat Heart ◽  
Perfused Hearts ◽  
Isolated Rat

Perfused hearts (n = 127) were exposed to acute hypoxia (10% O2 for 12 or 20 min) or left atrial stretch (increase in atrial pressure) in the presence or absence of 100 mumol/l ATP-sensitive potassium channel blocker (tolbutamide) or openers (pinacidil and diazoxide). Hypoxia alone elicited a prolonged atrial natriuretic factor (ANF) release, peaking at 74% over baseline (P < 0.01); with tolbutamide, ANF secretion peaked at 132% over baseline (P < 0.01). Pinacidil and diazoxide abolished the ANF response to hypoxia (P < 0.01). Atrial stretch alone (1 mmHg) transiently (2 min) increased ANF by 56% (P < 0.05); with tolbutamide, ANF increased transiently by 124% and showed a prolonged increase of 52% (P < 0.05). With tolbutamide, graded stretch (0.5-2.3 mmHg) induced a bell-shaped transient (2-min) increase of ANF release [-3% at 0.5 mmHg, 124% (P < 0.05) at 1.0 mmHg, 80% (P < 0.05) at 1.48 mmHg, and 14% at 2.22 mmHg] and a saturating prolonged ANF response. Tolbutamide increased the ANF response nonsignificantly at lower doses (30 mumol/l) and had no effect at 1 mumol/l. Pinacidil abolished the stretch-induced ANF release. These results suggest that ATP-sensitive potassium channels are extremely potent modulators of stimulated ANF secretion.

Comparative effects of calcium and potassium channel modulators on ischemia/reperfusion injury in the isolated rat heart

2018 ◽  
Vol 450 (1-2) ◽  
pp. 175-185 ◽  
Author(s):  
Nina Simonovic ◽  
Vladimir Jakovljevic ◽  
Jovana Jeremic ◽  
Zarko Finderle ◽  
Ivan Srejovic ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Reperfusion Injury ◽  
Rat Heart ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Isolated Rat Heart ◽  
Potassium Channel Modulators ◽  
Isolated Rat

Effect of Hydrogen Sulfide on Reactions of Isolated Rat Heart under Volume Load and Ischemia-Reperfusion

2013 ◽  
Vol 4 (3) ◽  
pp. 201-212
Author(s):  
Tetyana V Shimanskaya ◽  
Yulia V. Goshovska ◽  
Olena M. Semenykhina ◽  
Vadim F. Sagach
Keyword(s):  
Hydrogen Sulfide ◽  
Rat Heart ◽  
Ischemia Reperfusion ◽  
Isolated Rat Heart ◽  
Volume Load ◽  
Isolated Rat

‘Cross Talk’ Between Opioid Peptide and Adrenergic Receptor Signaling in Isolated Rat Heart

Circulation ◽  
1997 ◽  
Vol 95 (8) ◽  
pp. 2122-2129 ◽  
Author(s):  
Salvatore Pepe ◽  
Rui-Ping Xiao ◽  
Charlene Hohl ◽  
Ruth Altschuld ◽  
Edward G. Lakatta
Keyword(s):  
Cross Talk ◽  
Rat Heart ◽  
Adrenergic Receptor ◽  
Opioid Peptide ◽  
Isolated Rat Heart ◽  
Receptor Signaling ◽  
Isolated Rat

Comparison of Polarized and Depolarized Arrest in the Isolated Rat Heart for Long-term Preservation

Circulation ◽  
1997 ◽  
Vol 96 (9) ◽  
pp. 3148-3156 ◽  
Author(s):  
A. K. Snabaitis ◽  
M. J. Shattock ◽  
D. J. Chambers
Keyword(s):  
Rat Heart ◽  
Isolated Rat Heart ◽  
Long Term Preservation ◽  
Isolated Rat
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