scholarly journals Heat stress-induced protection of endothelial function against ischaemic injury is abolished by ATP-sensitive potassium channel blockade in the isolated rat heart

2000 ◽  
Vol 130 (2) ◽  
pp. 345-350 ◽  
Author(s):  
Marie Joyeux ◽  
Jean-François Bouchard ◽  
Daniel Lamontagne ◽  
Diane Godin-Ribuot ◽  
Christophe Ribuot
Keyword(s):  
Heat Stress ◽  
Endothelial Function ◽  
Potassium Channel ◽  
Rat Heart ◽  
Isolated Rat Heart ◽  
Channel Blockade ◽  
Ischaemic Injury ◽  
Potassium Channel Blockade ◽  
Isolated Rat

ATP-sensitive potassium channels regulate stimulated ANF secretion in isolated rat heart

1996 ◽  
Vol 271 (6) ◽  
pp. H2339-H2345 ◽  
Author(s):  
T. Xu ◽  
J. H. Jiao ◽  
R. A. Pence ◽  
A. J. Baertschi
Keyword(s):  
Potassium Channels ◽  
Potassium Channel ◽  
Rat Heart ◽  
Atrial Natriuretic Factor ◽  
Left Atrial ◽  
Channel Blocker ◽  
Acute Hypoxia ◽  
Isolated Rat Heart ◽  
Perfused Hearts ◽  
Isolated Rat

Perfused hearts (n = 127) were exposed to acute hypoxia (10% O2 for 12 or 20 min) or left atrial stretch (increase in atrial pressure) in the presence or absence of 100 mumol/l ATP-sensitive potassium channel blocker (tolbutamide) or openers (pinacidil and diazoxide). Hypoxia alone elicited a prolonged atrial natriuretic factor (ANF) release, peaking at 74% over baseline (P < 0.01); with tolbutamide, ANF secretion peaked at 132% over baseline (P < 0.01). Pinacidil and diazoxide abolished the ANF response to hypoxia (P < 0.01). Atrial stretch alone (1 mmHg) transiently (2 min) increased ANF by 56% (P < 0.05); with tolbutamide, ANF increased transiently by 124% and showed a prolonged increase of 52% (P < 0.05). With tolbutamide, graded stretch (0.5-2.3 mmHg) induced a bell-shaped transient (2-min) increase of ANF release [-3% at 0.5 mmHg, 124% (P < 0.05) at 1.0 mmHg, 80% (P < 0.05) at 1.48 mmHg, and 14% at 2.22 mmHg] and a saturating prolonged ANF response. Tolbutamide increased the ANF response nonsignificantly at lower doses (30 mumol/l) and had no effect at 1 mumol/l. Pinacidil abolished the stretch-induced ANF release. These results suggest that ATP-sensitive potassium channels are extremely potent modulators of stimulated ANF secretion.

Acute effects of cyclosporin and cremophor EL on endothelial function and vascular smooth muscle in the isolated rat heart

1992 ◽  
Vol 6 (1) ◽  
pp. 77-83 ◽  
Author(s):  
Pankaj Mankad ◽  
Jaroslav Spatenka ◽  
Zdenek Slavik ◽  
Gregory O'Neil ◽  
Adrian Chester ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Endothelial Function ◽  
Rat Heart ◽  
Isolated Rat Heart ◽  
Cremophor El ◽  
Acute Effects ◽  
Isolated Rat

Characterization of Endothelial Function Following Various Ischemic Durations in an Isolated Rat Heart Model of Donation After Circulatory Death

2017 ◽  
Vol 101 ◽  
pp. S53
Author(s):  
Natalia Méndez Carmona ◽  
Rahel K. Wyss ◽  
Maria Arnold ◽  
Hendrik T. Tevaearai Stahel ◽  
Thierry P. Carrel ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Rat Heart ◽  
Isolated Rat Heart ◽  
Donation After Circulatory Death ◽  
Heart Model ◽  
Circulatory Death ◽  
Isolated Rat

Comparative effects of calcium and potassium channel modulators on ischemia/reperfusion injury in the isolated rat heart

2018 ◽  
Vol 450 (1-2) ◽  
pp. 175-185 ◽  
Author(s):  
Nina Simonovic ◽  
Vladimir Jakovljevic ◽  
Jovana Jeremic ◽  
Zarko Finderle ◽  
Ivan Srejovic ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Reperfusion Injury ◽  
Rat Heart ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Isolated Rat Heart ◽  
Potassium Channel Modulators ◽  
Isolated Rat
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