PS01.004: UTILIZATION OF HIGH RESOLUTION IMPEDANCE MANOMETRY FOR LIVER TRANSPLANTATION PATIENTS WITH CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY AND DYSPHAGIA

Abstract Background Chronic inflammatory demyelinating polyneuropathy(CIDP) is a rare problem in liver transplantation recipients. We observed three patients with slowly progressive muscle weakness and dysphagia with body weight loss. Methods We describe the clinical features and high resolution impedance manometry(HRiM) results of 3 patients with liver transplantation who developed CIDP. Two patients had orthotopic liver transplantation and the other had living-donor liver transplantation. Results All 3 patients developed muscle weakness, dysphagia and body weight loss in the period of tapering immune suppressants. Diagnosis of CIDP were checked by neurologist consultation. All patients had immunosuppressive therapy with tacrolimus. Prednisolone in two cases and everolimus in one case were noted. Telbivudine treatment for chronic hepatitis B were given in all 3 patients. After HRiM evaluation, decreased functional oral intake scale(FOIS), distal contractile integral(DCI) and complete bolus rate were discovered. Plasma exchange were done and the follow up HRiM result showed obvious improved FOIS and DCI. Conclusion HRiM is a feasible and effective tool for evaluation of dysphagia in CIDP patients. This exam can be utilized before and after proper treatment. Disclosure All authors have declared no conflicts of interest.

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Nerve echogenicity and intranerve CSA variability in high-resolution nerve ultrasound (HRUS) in chronic inflammatory demyelinating polyneuropathy (CIDP)

Journal of Neurology ◽

10.1007/s00415-018-9158-3 ◽

2018 ◽

Vol 266 (2) ◽

pp. 468-475 ◽

Cited By ~ 9

Author(s):

Anna Lena Fisse ◽

Kalliopi Pitarokoili ◽

Jeremias Motte ◽

Donata Gamber ◽

Antonios Kerasnoudis ◽

...

Keyword(s):

High Resolution ◽

Chronic Inflammatory Demyelinating Polyneuropathy ◽

Demyelinating Polyneuropathy ◽

Nerve Ultrasound ◽

Inflammatory Demyelinating Polyneuropathy

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Chronic inflammatory demyelinating polyneuropathy complicating liver transplantation

Annals of Neurology ◽

10.1002/ana.410380519 ◽

1995 ◽

Vol 38 (5) ◽

pp. 828-831 ◽

Cited By ~ 20

Author(s):

Bruce V. Taylor ◽

Eelco F. M. Wijdicks ◽

John J. Poterucha ◽

Russel H. Weisner

Keyword(s):

Liver Transplantation ◽

Chronic Inflammatory Demyelinating Polyneuropathy ◽

Demyelinating Polyneuropathy ◽

Inflammatory Demyelinating Polyneuropathy

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Progressive muscle weakness and amyotrophy during pregnancy as the first manifestation of systemic lupus erythematosus: A case report and review of literature

Science Progress ◽

10.1177/00368504211050276 ◽

2021 ◽

Vol 104 (4) ◽

pp. 003685042110502

Author(s):

Liu Wang ◽

Dan Wang ◽

Yuyi Ruan ◽

Xionghui Chen ◽

Wei Chen ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Nephrotic Syndrome ◽

Peripheral Neuropathy ◽

Muscle Weakness ◽

Lupus Erythematosus ◽

Chronic Inflammatory Demyelinating Polyneuropathy ◽

Demyelinating Polyneuropathy ◽

Systemic Lupus ◽

Progressive Muscle Weakness ◽

Inflammatory Demyelinating Polyneuropathy

Background: Systemic lupus erythematosus is a common autoimmune disease involving multiple systems. Clinical involvement of the central and peripheral nervous systems is not unusual, but peripheral neuropathy in systemic lupus erythematosus with chronic inflammatory demyelinating polyneuropathy is uncommon. Our study aimed to illustrate the clinical features, diagnosis, and treatment of systemic lupus erythematosus combined with chronic inflammatory demyelinating polyneuropathy, and to aid in the identification of peripheral neuropathy in systemic lupus erythematosus. Methods: This article reports a case of systemic lupus erythematosus with onset in pregnancy, with chronic inflammatory demyelinating polyneuropathy as the first manifestation. We then analyze the identification of common peripheral neuropathy in systemic lupus erythematosus in detail, based on a literature review of confirmed cases of systemic lupus erythematosus combined with chronic inflammatory demyelinating polyneuropathy. Results: A 34-year-old woman presented progressive muscle weakness and muscular atrophy in the extremities during pregnancy, 3 years previously. At 4 months after onset, she had completely lost the ability to hold objects and walk, and had slight numbness in the limbs, without paresthesia. Her condition was misdiagnosed as “motor neuron disease” at the time. Three years after onset, her condition was revisited because of nephrotic syndrome, and she was diagnosed with nephrotic syndrome and peripheral nerve injury caused by systemic lupus erythematosus. After immunosuppressive treatment with corticosteroids and intravenous cyclophosphamide, her symptoms of muscle weakness were markedly improved. This article summarizes the characteristics of systemic lupus erythematosus combined with chronic inflammatory demyelinating polyneuropathy that have been reported in the literature, from the aspects of morbidity, disease progression, nerve injury, laboratory examinations, and treatment response. Conclusions: Our identification of a common peripheral neuropathy in systemic lupus erythematosus will help to improve clinicians’ understanding of various peripheral neuropathies in systemic lupus erythematosus. It will also aid in the early diagnosis and treatment of such patients, thus improving their long-term prognosis.

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