scholarly journals P543 The role of social support on psychological distress and health-related quality of life in adults with mild to moderately active Crohn’s disease

2021 ◽  
Vol 15 (Supplement_1) ◽  
pp. S513-S514
Author(s):  
S Regev ◽  
G Goren ◽  
D Schwartz ◽  
R Sergienko ◽  
M Friger ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Social Support ◽  
Crohn’S Disease ◽  
Psychological Distress ◽  
Crohn's Disease ◽  
Satisfaction With Life ◽  
Family Stress ◽  
Significant Other ◽  
Work Activity

Abstract Background Medical and psychological factors contribute to the heightened psychological distress and reduced health-related quality of life in patients with Crohn’s disease. Whether Social Support plays a role in this scenario is unknown. We used the Multidimensional Scale of Perceived Social Support (MSPSS) to investigate whether Social Support associates with psychological distress and quality of life in Crohn’s disease. Methods Consecutive adult patients with Crohn’s disease, presenting at specialist gastroenterology services or recruited by advertising, with mild to moderate disease activity by the Harvey-Bradshaw Index (HBI), were enrolled into the study. Patients completed the 12-item MSPSS questionnaire that measures psychological support in three categories: Family, Friends and Significant Other, and provides individual category scores and a total score (range of all scores 1–7; a higher score indicates more social support). Patients also completed the following questionnaires: psychological distress (Brief Symptom Inventory, with Global Severity Index, GSI), quality of life (Short Inflammatory Bowel Disease Questionnaire, SIBDQ), satisfaction with life (SWLS), family stress (Family Assessment Device, FAD), coping strategies (Brief-COPE), and presenteeism and work activity (WPAI). Statistics: Spearman rho. *p<0.05, **p<0.01. Results The cohort comprised 126 patients, mean (SD) age 33.7 (10.6) years, females 79%, HBI 8.4 (2.5), CRP 1.2 (2.3), calprotectin 394 (674). MSPSS scores were as follows: Total score 5.72 (1.14), Friends 5.36 (1.34), Family 5.73 (1.14), and Significant Other 6.07 (1.15); Cronbach’s α ≥ .877. MSPSS scores correlated negatively with family stress measure FAD: Friends -.258**, Family -.732**, Significant Other -.401**; and with GSI psychological stress measure: Friends -305**, Family -.352**, Significant Other -.245**. MSPSS correlated positively with SIBDQ quality of life: Friends .300**, Family .188*, Significant Other .200*; and with satisfaction with life SWLS: Friends .379**, Family .333**, Significant Other .245**. MSPSS correlations with emotion-focused coping were: Friends -.337**, Family -.263**, Significant Other -.329**. MSPSS Family score correlated negatively with WPAI presenteeism -.270*, and WPAI work activity -.294**. Conclusion In mild to moderate Crohn’s disease, strong social support was associated with better quality of life, more satisfaction with life, and better performance in the work arena. Social support was associated with reduced psychological distress, reduced family stress, and less use of emotion-focused coping. This research shows the importance of social support in improving the psychological condition of patients with Crohn’s disease.

scholarly journals A Model of the Quality of Life in Patients with Crohn’s Disease

2020 ◽  
Vol 27 (4) ◽  
pp. 333-343
Author(s):  
Shin Ae Lee
Keyword(s):  
Quality Of Life ◽  
Social Support ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Severity ◽  
Structural Equation ◽  
Pearson Correlation ◽  
Assessment Tools ◽  
Equation Modeling

Purpose: The purpose of this study was to develop and test a structural model for quality of life (QoL) in patients with Crohn’s disease.Methods: A total of 273 patients with Crohn’s disease were surveyed during their outpatient visits in the department of gastrointestinal internal medicine. Assessment tools consisted of the Inflammatory Bowel Disease Questionnaire for QoL, Perceived Stress Scale for stress, Beck Depression Inventory-II for depression, Fatigue Scale for fatigue, and Multidimensional Scale of Perceived Social Support for social support. Structural equation modeling was used for data analysis, descriptive statistics, Pearson correlation analysis, and factor analysis.Results: The modified model showed a good fit for the data. The model fit indices were <i>x</i><sup>2</sup>=9.36 (<i>p</i>=.671), RMSEA=.00, SRMR=.03, GFI=.99, AGFI=.97, NFI=.96, and CFI=1.00. The structure of the model demonstrated that disease severity, depression, stress, and social support explained 67.9% of the QoL of Crohn’s disease patients. The results showed that social support for patients with Crohn’s disease was high in terms of QoL; furthermore, when disease severity, depression, and stress were low, QoL was high.Conclusion: The results of this study show that disease severity, depression, stress, and social support have an important effect on the QoL of patients with Crohn’s disease. Therefore, it is necessary to take these variables into consideration when developing nursing interventions.

scholarly journals Effect of Originator Infliximab Treatment on Disease-Related Hospitalizations, Work Productivity and Activity Impairment, and Health Resource Utilization in Patients with Crohn’s Disease in a Real-Life Setting: Results of a Prospective Multicenter Study in Germany

2020 ◽  
pp. 1-13
Author(s):  
Niels Teich ◽  
Michael Bläker ◽  
Frank Holtkamp-Endemann ◽  
Eric Jörgensen ◽  
Andreas Stallmach ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Multicenter Study ◽  
Work Productivity ◽  
Infliximab Treatment ◽  
Prospective Multicenter Study ◽  
Hospitalization Rates ◽  
The Mean

<b><i>Introduction:</i></b> Infliximab (IFX) therapy is efficacious for inducing and maintaining symptomatic remission in patients with Crohn’s disease (CD), but whether this benefit results in reduced hospitalization rates and therefore may improve patients’ quality of life in an economically sensible way is conflicting so far. <b><i>Methods:</i></b> We conducted a noninterventional, multicenter, open-label, prospective study to evaluate the effect of originator IFX treatment on patient-reported outcomes and disease-related hospitalizations in adult CD patients in Germany treated for the first time with IFX according to label. <b><i>Results:</i></b> Two hundred and ninety-four patients were included in the study. We observed a statistically significant reduction in the number of CD-related hospitalizations from the year before baseline (mean 1.00 per patient, SD ± 0.93) to the mean value of the 1st (0.62, SD ± 0.95) and 2nd year (0.32, SD ± 0.75) of the observation period (<i>p</i> &#x3c; 0.0001). After 3 months of IFX therapy, work productivity and activity increased by an average of 12.6 and 17.1%, respectively. Patient’s clinical outcome was markedly improved as the total CD activity index (CDAI) sum score continuously decreased from baseline to month 24 and the mean score of the total inflammatory bowel disease questionnaire (IBDQ) changed substantially from 141 at baseline to 172 after 24 months of IFX treatment. Additionally, the number of work incapacity days declined. Recently, no new safety issues of IFX have been identified. <b><i>Conclusion:</i></b> In this large, prospective, multicenter study on disease-related hospitalization rates, work productivity, capacity for daily activities, and HRQoL in patients with CD, IFX significantly reduces their hospitalization rates and improves work productivity, daily activity, and quality of life over 24 months.

S1056 Quality-of-Life Improvements in Patients with Crohn's Disease Treated for 3 Years with Adalimumab in An Open-Label Extension of CHARM

2009 ◽  
Vol 136 (5) ◽  
pp. A-179 ◽  
Author(s):  
Edward V. Loftus ◽  
Jean-Frederic Colombel ◽  
Paul Rutgeerts ◽  
David T. Rubin ◽  
Naijun Chen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Open Label ◽  
Open Label Extension
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