scholarly journals P105. Inhibition of cytokine release from HT-29 cells and ulcerative colitis biopsies is potentiated by combination of selective kinase inhibitors, and such effects are mimicked by TOP1210, a narrow spectrum kinase inhibitor

2016 ◽  
Vol 10 (suppl 1) ◽  
pp. S140.2-S141
Keyword(s):  
Ulcerative Colitis ◽  
Kinase Inhibitors ◽  
Kinase Inhibitor ◽  
Cytokine Release ◽  
Narrow Spectrum ◽  
Ht 29

scholarly journals Effect of Narrow Spectrum Versus Selective Kinase Inhibitors on the Intestinal Proinflammatory Immune Response in Ulcerative Colitis

2016 ◽  
Vol 22 (6) ◽  
pp. 1306-1315 ◽  
Author(s):  
Paolo Biancheri ◽  
Martyn R. Foster ◽  
Matthew C. T. Fyfe ◽  
Thomas T. MacDonald ◽  
Sameer Sirohi ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Immune Response ◽  
Kinase Inhibitors ◽  
Narrow Spectrum ◽  
Spectrum Versus

scholarly journals P684 A first clinical trial of a novel narrow spectrum kinase inhibitor TOP1288 in patients with ulcerative colitis

2017 ◽  
Vol 11 (suppl_1) ◽  
pp. S429-S430 ◽  
Author(s):  
M. Taylor ◽  
A. Duggal ◽  
A. Rowley ◽  
M. Foster ◽  
S. Sirohi ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Clinical Trial ◽  
Kinase Inhibitor ◽  
Narrow Spectrum

scholarly journals Thrombotic microangiopathy in dasatinib-treated patients with chronic myeloid leukemia

2019 ◽  
Vol 4 (1-2) ◽  
pp. 41-45 ◽  
Author(s):  
Takeo Koshida ◽  
Sylvia Wu ◽  
Hitoshi Suzuki ◽  
Rimda Wanchoo ◽  
Vanesa Bijol ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitor ◽  
Tyrosine Kinase Inhibitors ◽  
Thrombotic Microangiopathy ◽  
Myeloid Leukemia ◽  
Kinase Inhibitors ◽  
Kidney Biopsy ◽  
Kinase Inhibitor ◽  
Target Effect

Dasatinib is the second-generation tyrosine kinase inhibitor used in the treatment of chronic myeloid leukemia. Proteinuria has been reported with this agent. We describe two kidney biopsy–proven cases of dasatinib-induced thrombotic microangiopathy that responded to stoppage of dasatinib and using an alternate tyrosine kinase inhibitor. Certain specific tyrosine kinase inhibitors lead to endothelial injury and renal-limited thrombotic microangiopathy. Hematologists and nephrologists need to be familiar with this off-target effect of dasatinib.

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