1182 Clinical evidence of the mitral valve leaflet remodeling after st-elevation acute myocardial infarction: longitudinal observation using real-time 3D echocardiography

Abstract Background Mitral valve (MV) leaflet remodeling after acute myocardial infarction (AMI) has been proposed as biological and physiological reaction under the ischemic environment mainly by animal experiments. Clinical evidence of leaflet growth after AMI is lacking. Purpose We aimed to assess the clinical evidence of the mitral valve leaflet remodeling after acute myocardial infarction by serial 2D/3D transthoracic echocardiography. Methods Sixty-six patients with first-onset ST-elevation MI (33 anterior and 33 inferior) were serially examined by 2D/3D-transthoracic echocardiography. MV complex geometry including leaflet surface area and leaflet thickness was quantitatively analyzed in acute phase and 6-month follow-up. Results 3D-leaflet surface area was significantly increased in 6-month follow-up (anterior MI; 5.58 [4.93-6.00] versus 5.98 [5.68-6.40] cm²/m²; P < 0.001, inferior MI; 5.48 [4.69-6.07] versus 5.79 [4.74-6.37] cm²/m²; P < 0.001). In anterior MI, both anterior and posterior leaflet lengths significantly increased (anterior leaflet; 12.78 [11.55-13.55] versus 13.63 [12.52-14.15] mm/m²; P = 0.001, posterior leaflet; 9.61 [8.73-10.77] versus 9.84 [8.94-10.96] mm/m²; P = 0.037). In inferior MI, posterior leaflet length significantly increased (9.18 [8.50-10.38] versus 10.00 [8.56-10.85] mm/m²; P = 0.029), while there was no significant change in anterior leaflet length (12.54 [11.61-13.56] versus 12.56 [12.08-14.06] mm/m²; P = 0.214). Leaflet thickness was found to become greater in both groups in 6-month follow-up (anterior MI; 1.08 [0.92-1.21] versus 1.32 [1.25-1.45] mm; P < 0.001, inferior MI; 1.14 [0.98-1.25] versus 1.32 [1.21-1.49] mm; P < 0.001) (Figure). Conclusions In six months from the onset of AMI, MV enlarged in area and increased in thickness. Anterior leaflet mainly enlarged in anterior MI, while posterior leaflet enlarged in inferior MI. This is the first clinical evidence of the MV remodeling after AMI, and long-year follow-up should contribute to assess the course of valve growth with relation to ischemic mitral regurgitation. Abstract 1182 Figure. 3D analysis of the mitral valve

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Correlations between 3D mitral valve parameters and left ventricular remodeling at 6 months after ST elevation myocardial infarction: pilot study

European Heart Journal ◽

10.1093/ehjci/ehaa946.0029 ◽

2020 ◽

Vol 41 (Supplement_2) ◽

Author(s):

A.I Scarlatescu ◽

S Onciul ◽

A Pascal ◽

D Zamfir ◽

I Petre ◽

...

Keyword(s):

Myocardial Infarction ◽

Mitral Valve ◽

Mitral Annulus ◽

3D Echocardiography ◽

Funding Source ◽

Posterior Leaflet ◽

Anterior Leaflet ◽

Lv Remodeling ◽

St Elevation

Abstract Background Mitral valve regurgitation and LV remodeling are associated with worse prognosis in acute ST elevation myocardial infarction (STEMI) patients. 3D echocardiography provides a more accurate assessment of mitral ring and leaflet remodeling thus offering a better understanding of mitral valve (MV) and LV geometrical changes in time. Purpose We aimed to assess the echocardiographic evidence of the mitral valve geometrical changes after STEMI. Methods In this prospective study we included 30 consecutive patients aged between 35 and 68 years old, with STEMI treated by primary PCI. All underwent conventional transthoracic echocardiography. In addition to conventional parameters we measured LV global longitudinal strain (GLS) and mitral valve parameters using 3D echocardiography (4D MV Assessment 2.2 software). All measuremets were performed at baseline and at 6 month follow up. LV remodeling was defined as an increase of over 15% of the LV end diastolic volume (LVEDV) at 6 months after the STEMI. Results We found significant differences in time between LVEF (39.22% vs 43.63%, p=0.00), VTDVS (116ml vs 120ml, p=0.00), LV GLS (−13.41 vs −15.52, p=0.10). LV remodeling at 6 months after STEMI has been observed in 17% of the patients. Regarding the type of the infarction, in anterior STEMI, anterior leaflet surface increased in time (from 6.44cmp vs 7.42cmp, p=0.05), while there was no significant change in posterior leaflet area. In inferior STEMI, the area of posterior mitral leaflet decreased (4.8 cmp vs 4.5 cmp, p=0.52) as well as the leaflet length (1.42 cm vs 1.19 cm p=0.003), but the anterior leaflet remained the same. At 6 months we observed significant differences between the 2 groups (with and without LV remodeling) in the following mitral valve 3D parameters: mitral annulus area (2.6 cmp vs 1.67 cmp, p=0.02), mitral circumference (2.57 cm vs 1.74 cm, p=0.021), bicomisural diameter (2.66 cm vs 2.16 cm, p=0.018), tenting area (p=0.009), anterior leaflet length (2,66 cm vs 2,015 cm p=0.018) and anterior leaflet area (3,69 cmp vs 2.49 cmp, p=0.002). Baseline LV GLS significantly correlated with the following mitral valve 3D parameters at 6 months: anterior leaflet area, posterior leaflet area, anterior leaflet length, tenting height, tenting area, mitral ring 3D area, anteroposterior and bicommissural diameters and mitral circumference (correlation coefficient >0.5). Using linear regression we proved that LV GLS can predict the shortening of the posterior MV (cut off −12.6, AUC 0.844, p=0.011) after 6 months follow up. These findings were independent of the presence and severity of mitral regurgitation. Conclusion Using 3D echocardiography, significant changes in mitral valve geometry were detected at 6 months follow up in STEMI patients. LV remodeling is associated with increased mitral annulus dimensions. Funding Acknowledgement Type of funding source: Other. Main funding source(s): This work was supported by CREDO Project - ID: 49182, financed through the SOP IEC -A2-0.2.2.1-2013-1 cofinanced by the ERDF.

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Longitudinal Evaluation of Mitral Valve Leaflet Remodeling After Acute Myocardial Infarction

Circulation Cardiovascular Imaging ◽

10.1161/circimaging.120.011396 ◽

2020 ◽

Vol 13 (12) ◽

Cited By ~ 1

Author(s):

Shun Nishino ◽

Nozomi Watanabe ◽

Toshihiro Gi ◽

Nehiro Kuriyama ◽

Yoshisato Shibata ◽

...

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Percutaneous Coronary Intervention ◽

Mitral Valve ◽

Primary Percutaneous Coronary Intervention ◽

Complex Geometry ◽

Coronary Intervention ◽

Mitral Valve Leaflet ◽

Percutaneous Coronary

Background: Recent animal studies have suggested that mitral valve (MV) leaflet remodeling can occur even without significant tethering force and that the postinfarct biological reaction would contribute to the histopathologic changes of the leaflet. We serially evaluated the MV remodeling in patients with anterior and inferior acute myocardial infarction (MI), by using 2- and 3-dimensional transthoracic echocardiography. Additional histopathologic examinations were performed to assess the leaflet pathology. Methods: Sixty consecutive first-onset acute MI (anterior MI, n=30; inferior MI, n=30) patients who underwent successful primary percutaneous coronary intervention were examined (1) before primary percutaneous coronary intervention, (2) at 6-month follow-up, and (3) at follow-up 1 year or later after onset. MV complex geometry including MV leaflet area and thickness was analyzed using dedicated software. Additional histopathologic study compared 18 valves harvested during surgery for ischemic mitral regurgitation (MR). Results: MV area and thickness incrementally increased during the follow-up period. MV leaflet area significantly increased (anterior MI: 5.59 [5.28–5.98] to 6.54 [6.20–7.26] cm 2 /m 2 , P <0.001; inferior MI: 5.60 [4.76–6.08] to 6.32 [5.90–6.90] cm 2 /m 2 , P <0.001), and leaflet thickness also increased (anterior MI: 1.09 [0.92–1.24] to 1.45 [1.28–1.60] mm/m 2 , P <0.001; inferior MI: 1.15 [1.03–1.25] to 1.44 [1.27–1.59] mm/m 2 , P <0.001); data represent onset versus ≥1 year. Larger annuls, larger tenting, and a reduced leaflet area/annular ratio with smaller coaptation index were observed in patients with persistent ischemic MR compared with those without significant ischemic MR. Histopathologic examinations revealed that MV thickness was significantly greater in chronic ischemic MR compared with acute ischemic MR (1432.6±490.5 versus 628.7±278.7 μm; P =0.001), with increased smooth muscle cells and fibrotic materials. Conclusions: MV leaflet remodeling progressed both in area and thickness after MI. This is the first clinical study to record the longitudinal course of MV leaflet remodeling by serial echocardiography.

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A kórelőzményben szereplő revascularisatiós műtét rövid és hosszú távú prognosztikai jelentősége szívinfarktus miatt kezelt betegekben

Orvosi Hetilap ◽

10.1556/650.2021.31988 ◽

2021 ◽

Vol 162 (5) ◽

pp. 177-184

Author(s):

András Jánosi ◽

Tamás Ferenci ◽

András Komócsi ◽

Péter Andréka

Keyword(s):

Diabetes Mellitus ◽

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Percutaneous Coronary Intervention ◽

Propensity Score ◽

Propensity Score Matching ◽

Coronary Intervention ◽

Percutaneous Coronary ◽

St Elevation

Összefoglaló. Bevezetés: A szívinfarktust megelőző revascularisatiós beavatkozások prognosztikai jelentőségével kapcsolatban kevés elemzés ismeretes, hazai adatokat eddig nem közöltek. Célkitűzés: A szerzők a Nemzeti Szívinfarktus Regiszter adatait felhasználva elemezték a koszorúér-revascularisatiós szívműtétet (CABG) túlélt betegek prognózisát heveny szívinfarktusban. Módszer: Az adatbázisban 2014. 01. 01. és 2017. 12. 31. között 55 599 beteg klinikai és kezelési adatait rögzítették: 23 437 betegnél (42,2%) ST-elevációval járó infarktus (STEMI), 32 162 betegnél (57,8%) ST-elevációval nem járó infarktus (NSTEMI) miatt került sor a kórházi kezelésre. Vizsgáltuk a CABG után fellépő infarktus miatt kezelt betegek klinikai adatait és prognózisát, amelyeket azon betegek adataival hasonlítottunk össze, akiknél nem szerepelt szívműtét a kórelőzményben (kontrollcsoport). Eredmények: A betegek többsége mindkét infarktustípusban férfi volt (62%, illetve 59%). Az indexinfarktust megelőzően a betegek 5,33%-ánál (n = 2965) történt CABG, amely az NSTEMI-betegeknél volt gyakoribb (n = 2357; 7,3%). A CABG-csoportba tartozó betegek idősebbek voltak, esetükben több társbetegséget (magas vérnyomás, diabetes mellitus, perifériás érbetegség) rögzítettek. Az indexinfarktus esetén a katéteres koszorúér-intervenció a kontrollcsoport STEMI-betegeiben gyakoribb volt a CABG-csoporthoz viszonyítva (84% vs. 71%). Az utánkövetés 12 hónapja során a betegek 4,7–12,2%-ában újabb infarktus, 13,7–17,3%-ában újabb katéteres koszorúér-intervenció történt. Az utánkövetés alatt a CABG-csoportban magasabbnak találtuk a halálozást. A halálozást befolyásoló tényezők hatásának korrigálására Cox-féle regressziós analízist, illetve ’propensity score matching’ módszert alkalmaztunk. Mindkét módszerrel történt elemzés azt mutatta, hogy a kórelőzményben szereplő koszorúér-revascularisatiós műtét nem befolyásolta a túlélést. Amennyiben a beteg kórelőzményében szerepelt a koszorúérműtét, az indexinfarktus nagyobb eséllyel volt NSTEMI, mint STEMI (HR: 1,612; CI 1,464–1,774; p<0,001). Következtetés: A kórelőzményben szereplő koszorúér-revascularisatiós műtét nem befolyásolta a szívinfarktus miatt kezelt betegek életkilátásait. Orv Hetil. 2021; 162(5): 177–184. Summary. Introduction: Little analysis is known about the prognostic significance of revascularization interventions before myocardial infarction; no domestic data have been reported so far. Method: The authors use data from the Hungarian Myocardial Infarction Registry to analyze the prognosis of patients with acute myocardial infarction who had previous coronary artery bypass grafting (CABG). Between 01. 01. 2014. and 31. 12. 2017, 55 599 patients were recorded in the Registry: 23 437 patients (42.2%) had ST-elevation infarction (STEMI) and 31 162 patients (57.8%) had non-ST-elevation infarction (NSTEMI). The clinical data and prognosis of patients treated for infarction after CABG were compared with those of patients without a CABG history. Results: The majority of patients were male (59% and 60%, respectively). Prior to index infarction, CABG occurred in 5.33% of patients (n = 2965), which was more common in NSTEMI (n = 2357; 7.3%). The CABG patients were older and had more comorbidities (hypertension, diabetes mellitus, peripheral vascular disease). For index infarction, percutaneous coronary intervention was more common in STEMI patients in the control group compared to CABG (84% vs. 71%). At 12 months of follow-up, 4.7–12.2% of patients had reinfarction, and 13.7–17.3% had another percutaneous coronary intervention. During the full follow-up, the CABG group had higher mortality. Cox regression analysis and propensity score matching were used to correct for the effect of other factors influencing mortality. Both analyses showed CABG did not affect survival. In the CABG group, the index infarction was more likely to be NSTEMI than STEMI (HR: 1.612; CI 1.464–1.774; p<0.001). Conclusion: The history of CABG does not affect the life expectancy of patients treated for an acute myocardial infarction. Orv Hetil. 2021; 162(5): 177–184.

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TCT-563 Early vascular responses to everolimus-eluting cobalt-chronium stent for the treatment of ST-elevation acute myocardial infarction: the results of the MECHANISM-AMI study 3-months OCT follow-up cohort

Journal of the American College of Cardiology ◽

10.1016/j.jacc.2016.09.701 ◽

2016 ◽

Vol 68 (18) ◽

pp. B227

Author(s):

Daisuke Terashita ◽

Yoshihiro Morino ◽

Hiromasa Otake ◽

Tatsuo Kikuchi ◽

Tetsuya Fusazaki ◽

...

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Vascular Responses ◽

St Elevation ◽

Elevation Acute Myocardial Infarction

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Clinical Application of Optical Coherence Tomography in Patients with Non-ST-Elevation Acute Coronary Syndrome Combined with Intermediate Lesions

The Heart Surgery Forum ◽

10.1532/hsf.1447 ◽

2017 ◽

Vol 20 (1) ◽

pp. 032

Author(s):

Hua Yu ◽

Likun Ma ◽

Kefu Feng ◽

Hongwu Chen ◽

Hao Hu

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Optical Coherence Tomography ◽

Acute Coronary Syndrome ◽

Drug Treatment ◽

Optical Coherence ◽

Coronary Syndrome ◽

St Elevation ◽

Elevation Acute Coronary Syndrome

Objective: This study aimed to evaluate the clinical significance and safety of optical coherence tomography (OCT) in patients with non-ST-elevation acute coronary syndrome (NSTEACS) combined with intermediate lesions.Methods: Sixty-five NSTEACS patients with intermediate lesions confirmed with coronary angiography at our department were included in this study. Among them, 33 patients received only standardized drug treatment (drug group) and the other 32 patients received percutaneous coronary intervention (PCI) according to the OCT examination based on drug treatment (OCT group). Major adverse cardiovascular events (MACEs), revascularization, success rate of OCT examination, related complications, and other patient situations in the two groups during hospitalization and the 12-month follow-up period were compared.Results: No death or stroke occurred in either group during hospitalization and follow-up. In the drug treatment group, six patients experienced frequent angina, and five patients with acute myocardial infarction were rehospitalized and underwent PCI procedures. In the OCT group, although two patients underwent repeat revascularization, no additional acute myocardial infarction events occurred. There was a statistically significant difference between the two groups (P < .01). All patients in the OCT group successfully completed the related vessel examination, and 24 patients underwent PCI procedures because of unstable plaque diagnosed with OCT.Conclusion: OCT-guided PCI is safe and effective for the treatment of patients with NSTEACS combined with intermediate lesions.

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Circulating Platelet-Derived Microparticles Associated with Postdischarge Major Adverse Cardiac Events in ST-Elevation Acute Myocardial Infarction

Cardiology Research and Practice ◽

10.1155/2020/6721584 ◽

2020 ◽

Vol 2020 ◽

pp. 1-10

Author(s):

Anggoro Budi Hartopo ◽

Dyah Samti Mayasari ◽

Ira Puspitawati ◽

Hasanah Mumpuni

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Major Adverse Cardiac Events ◽

Cardiac Events ◽

Prognostic Implication ◽

Adverse Cardiac Events ◽

St Elevation ◽

Elevation Acute Myocardial Infarction

Introduction. Platelet-derived microparticles (PDMPs) measurement adds prognostic implication for ST-elevation acute myocardial infarction (STEMI). The long-term implication of PDMPs in STEMI needs to be corroborated. Methods. The research design was a cohort study. Subjects were STEMI patients and were enrolled consecutively. The PDMPs were defined as microparticles bearing CD41(+) and CD62P(+) markers detected with flow cytometry. The PDMPs were measured on hospital admission and 30 days after discharge. The outcomes were major adverse cardiac events (MACE), i.e., a composite of cardiac death, heart failure, cardiogenic shock, reinfarction, and resuscitated ventricular arrhythmia, occurring from hospitalization until 1 year after discharge. Results. We enrolled 101 subjects with STEMI. During hospitalization, 17 subjects (16.8%) developed MACE. The PDMPs were not different between subjects with MACE and those without (median (IQR): 3305.0/μL (2370.0–14690.5/μL) vs. 4452.0/μL (2024.3–14396.8/μL), p=0.874). Forty-five subjects had increased PDMPs in 30 days after discharge as compared with on-admission measurement. Subjects with increased PDMPs had significantly higher 30-day MACE as compared to subjects with decreased PDMPs 17 (37.8%) vs. 6 (16.7%, p=0.036). There was a trend toward higher MACE in subjects with increased PDMPs as compared to those with decreased PDMPs in 90 days after discharge (48.9% vs. 30.6%, p=0.095) and 1 year after discharge (48.9% vs. 36.1%, p=0.249). Conclusion. The PDMPs level was increased from the day of admission to 30 days after discharge in patients with STEMI. The persistent increase in the PDMPs level in 30 days after the STEMI event was associated with the 30-day postdischarge MACE and trended toward increased MACE during the 90-day and 1-year follow-up.

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Isolated congenital cleft mitral valve leaflet: a rare cause of refractory cardiogenic shock complicating acute myocardial infarction

Journal of Congenital Cardiology ◽

10.1186/s40949-021-00062-2 ◽

2021 ◽

Vol 5 (1) ◽

Author(s):

Mubashir H. Bahrami ◽

Hamza Z. Ansari ◽

Maya Guglin ◽

Georges Ephrem ◽

George E. Revtyak

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Mitral Valve ◽

Cardiogenic Shock ◽

Mechanical Circulatory Support ◽

Circulatory Support ◽

Mitral Valve Leaflet ◽

Refractory Cardiogenic Shock ◽

Congenital Cleft ◽

Rare Diagnosis

AbstractWe report a unique presentation of isolated congenital cleft mitral valve complicating cardiogenic shock from acute myocardial infarction. Isolated cleft mitral valve is an uncommon diagnosis that can have significant clinical implications, especially if not recognized in patients presenting to the catheterization lab with acute myocardial infarction and cardiogenic shock. A review of this rare diagnosis including the options and timing of therapeutic interventions, which can include MitraClip, is important for publication.The case is of a patient who presented with an anterior acute ST elevation myocardial infarction. Despite early coronary revascularization and conventional support, refractory cardiogenic shock ensued requiring mechanical circulatory support escalation to Veno-arterial extracorporeal membrane oxygenation. Subsequently, left ventriculography revealed a massively dilated left atrium and severe mitral regurgitation raising concerns for a mechanical mitral valve complication. The patient was taken to the operating room for possible mitral valve surgery, but a preoperative transesophageal echocardiogram revealed an isolated posterior cleft mitral valve. Since the patient had stabilized on mechanical circulatory support, emergent surgery was deferred. The patient successfully recovered during index hospitalization with mechanical circulatory support and discharged on guideline directed medical therapy.In conclusion, isolated cleft mitral valve is a rare diagnosis that can often be underrecognized without comprehensive 3-dimensional transesophageal echocardiography evaluation. If diagnosed early with significant regurgitation, surgical treatment results in good outcomes and preservation of LV systolic function. Percutaneous correction of a CMVL with MitraClip has been described and may offer an alternative approach for high risk surgical patients.

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Premolded Bovine Pericardial Chords for Replacement of Ruptured or Elongated Chordae Tendineae

The Heart Surgery Forum ◽

10.1532/hsf98.20091053 ◽

2010 ◽

Vol 13 (1) ◽

pp. 17

Author(s):

Francisco Gregori ◽

Jo�o Carlos Leal ◽

Domingo Marcolino Braile

Keyword(s):

Pulmonary Embolism ◽

Mitral Valve ◽

Early Postoperative Period ◽

Time Range ◽

Mitral Insufficiency ◽

Posterior Leaflet ◽

Anterior Leaflet ◽

Chordae Tendineae ◽

Leaflet Coaptation

Background: The aim of this study was to assess by Doppler echocardiography (ECO) the functioning of the mitral valve apparatus in patients who have undergone implantation of standardized bovine pericardium chordae (SBPC) for replacement of ruptured or elongated chordae tendineae with significant thinning.Methods: SBPC were implanted in 31 patients who had mitral insufficiency due to rupture of chordae tendinae or elongated chordae with significant thinning. Patient ages ranged from 19 to 85 years (mean of 58 years). The most frequent cause of mitral insufficiency was fibroelastic degeneration in 25 patients (80.6%). The SBPC were fashioned as a set, joined at their extremities by 2 polyester-reinforced rods forming a monobloc. The SBPC were 2-mm wide and were positioned parallel to one another at a distance of 3 mm. Each set of SBPC had a corresponding measurer, and their length ranged from 20 to 35 mm. In 21 patients (67.7%) the SBPC were implanted in the posterior leaflet and in 10 patients (32.3%) in the anterior leaflet (in 2 patients concurrently in the anterior and posterior leaflets). All patients were assessed by ECO postoperatively, with a 20-month mean follow-up time (range 6-45 months).Results: One patient (3.2%) died of pulmonary embolism during the early postoperative period. Postoperative ECO showed absence of mitral regurgitation in 17 patients (54.8%), mild regurgitation in 9 (29.0%), and mild-to-moderate regurgitation in 4 (12.9%). Opening and mobility of the mitral valve were normal in the 30 surviving patients.Conclusion: The ECO revealed good functionality of the mitral valve apparatus with appropriate leaflet coaptation in patients who had undergone implantation of SBPC for replacement of ruptured or elongated and thinned chordae. A longer follow-up is required to assess absence of calcification and/or degeneration of the SBPC.

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