P991Pattern of rapid activity is preserved in persistent AF in selected locations after pulmonary vein isolation

EP Europace ◽  
2020 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
S Nagy ◽  
P Kasi ◽  
V Afonso ◽  
I Mann ◽  
S Kim ◽  
...  
Keyword(s):  
Pulmonary Vein ◽  
Pulmonary Vein Isolation ◽  
Cycle Length ◽  
Driving Mechanisms ◽  
Automated Algorithm ◽  
Educational Grant ◽  
Cumulative Duration ◽  
Double Spiral ◽  
Number Of Segments ◽  
Funding Acknowledgements

Abstract Funding Acknowledgements Our research group receives an educational grant from Abbott Inc. Introduction. There is evidence to suggest that structural remodelling in psAF potentially gives rise to areas of rapid cycle length activity that may act as driving mechanisms. We describe a new method to compare rapid activity (RA) in psAF prior to and after pulmonary vein isolation, in extended AF segments (EAFS). We focus on patterns of RA, based on the hypothesis that AF drivers are transient but recur in the same locations.  Methods. Five patients (61 ± 8 years of age, 3 male) for catheter ablation of psAF were included. 3D maps were collected with a double spiral 20 pole catheter. In stable locations, pre and post PVI, 37s EAFS were recorded using 8s segments, automatically every 1s, creating a 7s overlap between segments. Dominant cycle length (DCL) was determined for every 8s segment by a fully automated algorithm. RA was defined as the rapidest 20th percentile for each patient. RA episodes consisted of continuous segments with rapid DCL (black lines in Fig 1) and terminated with a non-rapid segment (red lines on Fig 1). Episodes were truncated where overlap occurred (Box 1 and Box 2 in Fig 1). The pattern of RA was assessed by the number, cumulative duration and mean duration of RA episodes within an EAFS pre and post PVI. Results. Mean DCL of EAFS increased significantly in 4/5 patients after PVI, the number of EAFS with rapid activity showed a reduction in all patients.  The percentage of new sites with RA post PVI was 27%. The number of sites that retained RA post PVI was 14 ± 11.3 (58.3%; Table 1).  Of these, number and cumulative duration of RA did not change in 4/5 patients, and mean duration of RA remained stable in 5/5. Conclusion. An automated DCL algorithm shows that, in most cases, global AFCL prolongs significantly with PVI overall, but selected foci retain RA and RA patterns. These may represent active drivers, as their activity appears to be independent of their surroundings. Table 1 Patient ID Number of segments Mean AFCL ± SD of all segments Number of EAFS with rapid activity Pre-PVI Post-PVI P Pre-PVI Post-PVI New sites 1 145 135 ± 8.9 141 ± 9.8 <0.001 94 62 15 2 121 154 ± 12.9 162 ± 15.0 <0.001 94 72 11 3 172 148 ± 13.7 160 ± 16.6 <0.001 108 82 25 4 301 172 ± 22.9 174 ± 21.5 0.418 198 189 58 5 200 177 ± 9.9 215 ± 18.1 <0.001 87 43 14 Pre and Post PVI cycle length and EAFS with rapid activity. (AFCL: AF cycle length; EAFS: Extended AF segments; PVI: Pulmonary vein isolation) Abstract Figure.

scholarly journals Effect of pulmonary vein isolation on atrial fibrillation cycle length

2002 ◽  
Vol 39 ◽  
pp. 90
Author(s):  
Mehmet Ozaydin ◽  
William Hsu ◽  
Hiroshi Tada ◽  
Aman Chugh ◽  
Christoph Scharf ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Pulmonary Vein ◽  
Pulmonary Vein Isolation ◽  
Cycle Length

scholarly journals Is the optimal blanking period duration after cryoballoon pulmonary vein isolation impacted by use of antiarrhythmic drugs?

EP Europace ◽  
2021 ◽  
Vol 23 (Supplement_3) ◽  
Author(s):  
D Musat ◽  
NS Milstein ◽  
M Saberito ◽  
A Bhatt ◽  
M Habibi ◽  
...  
Keyword(s):  
Pulmonary Vein ◽  
Pulmonary Vein Isolation ◽  
Loop Recorder ◽  
Funding Sources ◽  
Very High ◽  
Period Duration ◽  
Af Recurrence ◽  
Funding Acknowledgements

Abstract Funding Acknowledgements Type of funding sources: None. Background Cryoballoon pulmonary vein isolation (CB) is an accepted method for ablation in patients with atrial fibrillation (AF). A three-month blanking period (BP) is commonly used in clinical trials and practice. However, when the optimal BP duration differs in patients (pts) on or off an antiarrhythmic drug (AAD) at time of ablation remains undefined. Objective To compare the BP duration in pts undergoing CB while either taking or not taking an AAD. Methods We enrolled consecutive pts with AF who had CB PVI while on an AAD. All pts had an implantable loop recorder (ILR). We prospectively followed all pts and determined the time to last AF episode during the 90-day post-PVI BP. This was then correlated with likelihood of having an AF recurrence between 3-12 months post-PVI. Results The cohort included 164 pts (66 ± 9 years; 97 [60%] male; 90 [55%] PAF; CHA2DS2-VASc 2.7 ± 1.7). Ablation was performed with 92 (56%) pts taking an AAD, which was stopped at a median of 80 [36, 105] days post-PVI. We defined 4 distinct groups: (1) no AF in 90-day BP (n = 75 [46%]); (2) last AF within 30 days of PVI (n = 32 [20%]); (3) last AF within 60 days of PVI (n = 17 [10%]); and (4) last AF within 90 days of PVI (n = 40 [24%]). Following the 90-day BP, 81 (49%) pts had a recurrence of AF. Long-term freedom from recurrent AF was similar in pts who did and did not use an AAD, irrespective of BP duration (Figure). Conclusion Our data suggest that the optimal BP duration in AF patients undergoing CB PVI while taking an AAD is 30 days. An AF recurrence after 30 days is associated with a very high likelihood of recurrent AF during longer-term follow-up, irrespective of whether an AAD is being used or not. Abstract Figure.

scholarly journals Prospective STAR-Guided Ablation in Persistent Atrial Fibrillation Using Sequential Mapping With Multipolar Catheters

2020 ◽  
Vol 13 (10) ◽  
Author(s):  
Shohreh Honarbakhsh ◽  
Richard J. Schilling ◽  
Malcolm Finlay ◽  
Emily Keating ◽  
Ross J. Hunter
Keyword(s):  
Atrial Fibrillation ◽  
Pulmonary Vein ◽  
Pulmonary Vein Isolation ◽  
Cycle Length ◽  
Atrial Tachycardia ◽  
Antiarrhythmic Drugs ◽  
Persistent Atrial Fibrillation ◽  
Unique Identifier ◽  
Long Term Follow Up

Background: A novel stochastic trajectory analysis of ranked signals (STAR) mapping approach to guide atrial fibrillation (AF) ablation using basket catheters recently showed high rates of AF termination and subsequent freedom from AF. Methods: This study aimed to determine whether STAR mapping using sequential recordings from conventional pulmonary vein mapping catheters could achieve similar results. Patients with persistent AF<2 years were included. Following pulmonary vein isolation AF drivers (AFDs) were identified on sequential STAR maps created with PentaRay, IntellaMap Orion, or Advisor HD Grid catheters. Patients had a minimum of 10 multipolar recordings of 30 seconds each. These were processed in real-time and AFDs were targeted with ablation. An ablation response was defined as AF termination or cycle length slowing ≥30 ms. Results: Thirty patients were included (62.4±7.8 years old, AF duration 14.1±4.3 months) of which 3 had AF terminated on pulmonary vein isolation, leaving 27 patients that underwent STAR-guided AFD ablation. Eighty-three potential AFDs were identified (3.1±1.1 per patient) of which 70 were targeted with ablation (2.6±1.2 per patient). An ablation response was seen at 54 AFDs (77.1% of AFDs; 21 AF termination and 33 cycle length slowing) and occurred in all 27 patients. No complications occurred. At 17.3±10.1 months, 22 out of 27 (81.5%) patients undergoing STAR-guided ablation were free from AF/atrial tachycardia off antiarrhythmic drugs. Conclusions: STAR-guided AFD ablation through sequential mapping with a multipolar catheter effectively achieved an ablation response in all patients. AF terminated in a majority of patients, with a high freedom from AF/atrial tachycardia off antiarrhythmic drugs at long-term follow-up. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT02950844.

P975Composite electroanatomical maps locate rapid activity within low voltage zones in persistent AF

EP Europace ◽  
2020 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
S Nagy ◽  
P Kasi ◽  
V Afonso ◽  
I Mann ◽  
S Kim ◽  
...  
Keyword(s):  
Pattern Recognition ◽  
Catheter Ablation ◽  
Pulmonary Vein ◽  
Cycle Length ◽  
Low Voltage ◽  
Complex Pattern ◽  
Extensive Experience ◽  
Mean Values ◽  
Double Spiral ◽  
Automated Algorithms

Abstract Funding Acknowledgements Our research group receives an educational grant from Abbott Inc. Introduction. Outcomes from catheter ablation of persistent AF (psAF) are not favourable. The two prevailing major directions to improve success are left atrial (LA) substrate ablation, and non pulmonary vein driver ablation. In LA substrate ablation guided by intracardiac voltage, there is debate on the most fitting mapping rhythm and the appropriate cut offs for low voltage zones (LVZ). Non pulmonary vein driver ablation requires extensive experience and relies on complex pattern recognition by the operator, introducing subjectivity, that may lead to reduced reproducibility. AF drivers have been shown to localise to LVZs. We propose an objective, patient-tailored method of identifying rapid activity within LVZs to locate drivers of psAF.  Methods. Eleven patients (61 ± 10.8 years of age, 9 male) undergoing first time catheter ablation for psAF were included. 3D maps were collected with a double spiral 20 pole catheter, in non-cardiac triggered mode, recording 8s segments at each bipole. Mean AF voltage (AFV) a AF cycle length (AFCL) was calculated for each 8s segment using automated algorithms. Grades of rapid activity and low voltage were defined as the 10th 20th and 30th percentile of all collected points within a patient. Percentile-matched composite LVZ-ARA maps were created on a research platform.  Results. Mean LVZ percentage of the total mapped area was 4.67 ± 2.4%, 13.95 ± 3.8%, 23.81 ± 5.7% for the 10th, 20th and 30th percentiles respectively (Table 1). Mean, percentile matched LVZ-ARA overlap area percentage of the total mapped area was 0.3 ± 0.25% (10th-10th), 0.86 ± 0.58 (20th-20th), 3.1 ± 1.9% (30th-30th). ARAs represented a small proportion of all LVZs. Location of overlap areas differed significantly between patients and were marked with colours. Multi-colour areas including purple represent LVZ, multi-colour areas excluding purple, show LVZ-ARA overlap (examples in Fig 1).  Conclusion. Analysis of LVZ-ARA overlap by mean AFV and AFCL provides an objective method of identifying potential drivers that localise to LVZs. The identified overlap areas constituted small, occasionally disparate areas within the LVZ of the LA. By adjusting the AFCL and AFV percentiles, the overlap areas can be tailored at the operator’s discretion, maintaining reproducible, objective decision making, without the need for complex pattern recognition. If ablation is planned, established techniques can be used to target the overlap areas, such as homogenisation or transection and connection to anatomical or ablative non-conductive tissues. AFCL 10th AFCL 20th AFCL 30th AFV 10th AFV 20th AFV 30th All patients 128 ± 13 ms 144 ± 10 ms 150 ± 9 ms 0.15 ± 0.02 mV 0.19 ± 0.03 mV 0.24 ± 0.04 mV Mean values of percentile cut offs. AFCL: AF cycle length; AFV: AF voltage Abstract Figure. Fig 1

The efficacy of class III D,L sotalol in treatment of left atrial tachycardia after pulmonary vein isolation

2009 ◽  
Vol 150 (36) ◽  
pp. 1694-1700 ◽  
Author(s):  
Attila Mihálcz ◽  
Csaba Földesi ◽  
Attila Kardos ◽  
Károly Ladunga ◽  
Tamás Szili-Török
Keyword(s):  
Pulmonary Vein ◽  
Pulmonary Vein Isolation ◽  
Left Atrial ◽  
Atrial Tachycardia ◽  
Class Iii

Pitvarfibrilláció miatt végzett pulmonalis vena izolációját követően a betegek egy részénél iatrogén bal pitvari tachycardia jelentkezik. Cél: A sotalolterápia hatásosságának összehasonlítása az 1C tip. propafenonnal szemben, a postablatiós arrhythmiák kezelésében. Módszer és eredmények: A vizsgálatba 75, pitvarfibrillációban szenvedő beteget (átlagéletkor 55,4 ± 7,14 év) választottunk, akiknél a pulmonalis vénák valódi elektromos izolálását végeztük. A beavatkozás során az elektromos izolációt körkörös multipoláris katéterrel ellenőriztük. Az ablatiót követően folytattuk az antiarrhythmiás terápiát még minimum 6 hétig, de célunk annak leépítése volt. Az utánkövetést 1, majd 3 havonta tervezett, ambuláns vizsgálatok alapján végeztük. A 12. hónap végén 67 betegnél tudtuk a protokoll szerint gyűjtött adatokat elemezni. 21 betegnél jelentkezett 3 hónapot követően tartósan bal pitvari tachycardia (31,3%). 11 beteg propafenon-, 4 beteg amiodaron- és 6 beteg sotalolterápiában részesült. Az első két csoportnál sotalolterápiára váltottunk, míg az utolsó csoportnál propafenonterápiát kezdtünk. A 12. hónap végére a sotalol hatásossága 80%, a propafenon hatásossága 20% volt. Következtetések: Adataink alapján PV-izolációt követően a sotalolterápia nem hatásosabb a bal pitvari tachycardiák megelőzésében, mint a propafenon. A 3 hónapon túl fellépő postablatiós bal pitvari tachycardiák kezelésében a sotalol hatásosabb, mint az IC-csoportba tartozó propafenon.

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